iPTMnet Report for P23560 (BDNF)
Protein Information
| UniProt AC / UniProt ID | P23560 / BDNF_HUMAN |
| Protein Name | Brain-derived neurotrophic factor precursor |
| Gene Name | Name: BDNF |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P23560 |
| PRO Name | brain-derived neurotrophic factor (human) |
| Definition | A brain-derived neurotrophic factor that is encoded in the genome of human. |
| Short Label | hBDNF |
| Category | organism-gene |
DAG ViewP23560 (BDNF) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K50 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T62 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 23712400 | ||
| T62 | Phosphorylation | O96017 (CHEK2) | score2 | PhosphoSitePlus | 23712400 | |
| K85 | Acetylation | score1 | PhosphoSitePlus | |||
| K85 | Ubiquitination | score1 | PhosphoSitePlus | |||
| N121 | N-Glycosylation | score4 | GlyGen UniProt | 19467646, 11152678 | ||
| T155 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K174 | Ubiquitination | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T15 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S19 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y20 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S19 | L19 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| Y20 | C20 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| K50 | N50 | Biomuta | DOID:3571 / liver cancer [ cosmic ] |
