Protein Information

Cytoscape View


UniProt AC / UniProt ID P23528 / COF1_HUMAN
Protein Name Cofilin-1
Gene Name Name: CFL1
Synonyms:CFL;
Organism Homo sapiens (Human)

PRO ID PR:P23528
DAG View
PRO Name cofilin-1 (human)
Definition A cofilin-1 that is encoded in the genome of human.
Short Label hCFL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23528 (CFL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 19369195, 21406692, ...22223895, 22814378, 30550596, 20068231, 25944712
S3 Phosphorylation P53667 (LIMK1) , P53671 (LIMK2) , Q13418 (ILK) , Q15139 (PRKD1) , Q96S53 (TESK2) , Q15569 (TESK1) , Q7Z2Y5 (NRK) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 11294912, 19029335, 30824802, ...22550395, 28704726, 30711747, 18252715, 10613909, 23170111, 21406692, 29029503, 22970259, 14645219, 17130184, 17470633, 11571311, 18079118, 29844397, 24664099, 19329994, 11171090, 15866889, 29184140, 23951242, 19369195, 22593798, 17081983, 16456544, 30662943, 18309290, 20558337, 11418599, 19339277, 24795566, 19413330, 18578522, 23060131, 12361576, 30792702, 19562668, 15901596, 25549357, 18702456, 12837278, 25714964, 25486435, 23112838, 25864508, 17954607, 20058876, 28274853, 23897816, 11925442, 16505165, 11784854, 27595610, 29071730, 28381571, 30115939, 30550596, 18459146, 16230460, 20068231, 11093160, 20610540, 10644754, 26269174, 22869619, 30131725, 15591324, 23022583, 23186163, 29724193, 10436159, 24284899, 28679472, 26169356, 15660133, 31442208, 15584898, 14636893, 26056138, 12451591, 26271467, 19651622, 23934191, 18669648, 25684665, 27462783, 23153585, 24478456, 12655149, 15671020, 15159416, 9864364, 25179631, 26967395, 24486488, 11276226, 20825680, 22019611, 29396473, 11340065, 24840177, 29111771, 9655398, 28939776, 24425731, 31213900, 28489960, 22216116, 27573465, 18771940, 18491316, 26880202, 18070928, 16803871, 18096821, 21221513, 25781955
S8 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
K13 Acetylation PhosphoSitePlus   UniProt 19608861
K13 Sumoylation PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
K19 Acetylation PhosphoSitePlus
K19 Methylation PhosphoSitePlus
K19 Sumoylation PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
K22 Acetylation PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus
S23 Phosphorylation P17252 (PRKCA) HPRD   PhosphoSitePlus   RLIMS-P   Signor 19651622, 28303963, 20068231, ...22855535
S24 Phosphorylation P17252 (PRKCA) HPRD   PhosphoSitePlus   RLIMS-P   Signor 19651622, 28303963, 22855535
T25 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 17081983, 20068231
K30 Acetylation PhosphoSitePlus
K30 Sumoylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
K31 Acetylation PhosphoSitePlus
K33 Acetylation PhosphoSitePlus
K34 Sumoylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
C39 S-Nitrosylation dbSNO 2212679, 22126794, 24105792, ...26338901
S41 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163
K44 Acetylation PhosphoSitePlus
K44 Sumoylation PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
K45 Acetylation PhosphoSitePlus
K45 Sumoylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K53 Sumoylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
T63 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 30550596
Y68 Phosphorylation P12931 (SRC) HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 15592455, 19802004, 19690332, ...16497976
T70 Phosphorylation PhosphoSitePlus
K73 Acetylation PhosphoSitePlus   UniProt 19608861
K73 Ubiquitination PhosphoSitePlus
K78 Acetylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
C80 S-Nitrosylation dbSNO 26338901, 24105792
Y82 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 30550596
Y85 Phosphorylation HPRD   PhosphoSitePlus 17016520
T88 Phosphorylation PhosphoSitePlus
Y89 Phosphorylation HPRD   PhosphoSitePlus 15951569
T91 Phosphorylation PhosphoSitePlus
K92 Acetylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K96 Acetylation PhosphoSitePlus
K96 Methylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 30550596
K112 Sumoylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K114 Acetylation PhosphoSitePlus
K114 Sumoylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
Y117 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
K121 Acetylation PhosphoSitePlus
K121 Sumoylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K125 Acetylation PhosphoSitePlus
K126 Acetylation PhosphoSitePlus
K127 Acetylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
T129 Phosphorylation PhosphoSitePlus
K132 Acetylation PhosphoSitePlus
K132 Sumoylation PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
C139 S-Nitrosylation dbSNO 2212679, 22126794, 24105792, ...26338901
Y140 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15592455, 18083107, 17389395, ...17016520
K144 Acetylation PhosphoSitePlus   UniProt 19608861
K144 Ubiquitination PhosphoSitePlus
C147 S-Nitrosylation dbSNO 19483679
K152 Acetylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
S156 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18669648, ...30550596, 19690332, 20068231
S160 Phosphorylation PhosphoSitePlus
K164 Sumoylation PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046697 (hCFL1/InitMet-/Phos:1) pS3 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y82 H82 Biomuta DOID:1909 / melanoma [ tcga ]
K92 E92 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K95 Q95 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
K112 N112 Biomuta DOID:363 / uterine cancer [ tcga ]
S119 R119 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S120 F120 Biomuta DOID:1909 / melanoma [ tcga ]
K152 N152 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]