Protein Information

Cytoscape View


UniProt AC / UniProt ID P23526 / SAHH_HUMAN
Protein Name Adenosylhomocysteinase
Gene Name Name: AHCY
Synonyms:SAHH;
Organism Homo sapiens (Human)

PRO ID PR:P23526
DAG View
PRO Name adenosylhomocysteinase (human)
Definition An adenosylhomocysteinase that is encoded in the genome of human.
Short Label hAHCY
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23526 (AHCY) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
K4 Acetylation PhosphoSitePlus
K4 Ubiquitination PhosphoSitePlus
K8 Methylation PhosphoSitePlus
K8 Ubiquitination PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
R34 Methylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus
K103 Acetylation PhosphoSitePlus
T136 Phosphorylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
Y143 Phosphorylation PhosphoSitePlus
R151 Methylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
T158 Phosphorylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus   UniProt 23186163
K186 Ubiquitination PhosphoSitePlus
K188 Acetylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
Y193 Phosphorylation PhosphoSitePlus
C195 S-Nitrosylation dbSNO 24105792
S198 Phosphorylation PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
Y221 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
R233 Methylation PhosphoSitePlus
K291 Methylation PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
K322 Sumoylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
Y379 Phosphorylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K401 Acetylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
K405 Acetylation PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
K408 Acetylation PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
T410 Phosphorylation PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
Y416 Phosphorylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus
C421 S-Nitrosylation dbSNO 26338901
K426 Acetylation PhosphoSitePlus
Y430 Phosphorylation PhosphoSitePlus
R431 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R34 H34 Biomuta DOID:363 / uterine cancer [ tcga ]
Y143 C143 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R151 * Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K174 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S183 A183 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S183 F183 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
R233 Q233 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K318 M318 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
C421 Y421 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ] DOID:3070 / malignant glioma [ tcga ]
K426 N426 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y430 H430 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
R431 C431 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]