iPTMnet Report for P23497 (SP100)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P23497 / SP100_HUMAN
Protein Name Nuclear autoantigen Sp-100
Gene Name Name: SP100
Organism Homo sapiens (Human)

PRO ID PR:P23497
DAG View
PRO Name nuclear autoantigen Sp-100 (human)
Definition A nuclear autoantigen Sp-100 that is encoded in the genome of human.
Short Label hSP100
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23497 (SP100) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
S18 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 24275569
T39 Phosphorylation PhosphoSitePlus
Y50 Phosphorylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
S157 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...24275569, 20068231
S166 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
T176 Phosphorylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus   UniProt 23186163
S189 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
T197 Phosphorylation PhosphoSitePlus
T198 Phosphorylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
T221 Phosphorylation PhosphoSitePlus
T222 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus   UniProt 24275569
S231 Phosphorylation PhosphoSitePlus
T234 Phosphorylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
K297 Sumoylation PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
K300 Acetylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K306 Acetylation PhosphoSitePlus
K306 Sumoylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
S327 Phosphorylation phospho.ELM 17081983
S328 Phosphorylation phospho.ELM 17081983
S331 Phosphorylation phospho.ELM   UniProt 17081983
S334 Phosphorylation phospho.ELM 17081983
T335 Phosphorylation phospho.ELM 17081983
S350 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
K366 Sumoylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K387 Sumoylation PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus   UniProt 23186163
K396 Sumoylation PhosphoSitePlus
S407 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18669648, 24275569, ...19690332, 20068231
S409 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18669648, 24275569, ...19690332, 20068231
S410 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18669648, 24275569, ...19690332, 20068231
S419 Phosphorylation PhosphoSitePlus
K430 Acetylation PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
S451 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S452 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S453 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S456 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S459 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S476 Phosphorylation PhosphoSitePlus
K486 Acetylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
T525 Phosphorylation PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
T560 Phosphorylation PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
K594 Ubiquitination PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus
K613 Ubiquitination PhosphoSitePlus
T639 O-Glycosylation GlyGen 23301498, 28411811, 29351928
K673 Ubiquitination PhosphoSitePlus
S680 O-Glycosylation GlyGen 23301498, 28411811, 29351928
T681 O-Glycosylation GlyGen 23301498, 28411811, 29351928
K731 Acetylation PhosphoSitePlus
K733 Acetylation PhosphoSitePlus
K733 Methylation PhosphoSitePlus
K733 Ubiquitination PhosphoSitePlus
K739 Acetylation PhosphoSitePlus
K739 Ubiquitination PhosphoSitePlus
K750 Ubiquitination PhosphoSitePlus
T751 Phosphorylation PhosphoSitePlus
Y752 Phosphorylation PhosphoSitePlus
K764 Acetylation PhosphoSitePlus
K764 Methylation PhosphoSitePlus
K764 Ubiquitination PhosphoSitePlus
K786 Ubiquitination PhosphoSitePlus
Y818 Phosphorylation PhosphoSitePlus
Y836 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation HPRD 20058876, 17081983, 20068231
Y50 Phosphorylation HPRD 20068231
S157 Phosphorylation HPRD 17322306, 18452278, 19651622, ...18669648, 20166139, 20068231
S327 Phosphorylation HPRD 17081983
S328 Phosphorylation HPRD 17081983
S331 Phosphorylation HPRD 17081983
S334 Phosphorylation HPRD 17081983
T335 Phosphorylation HPRD 17081983
S362 Phosphorylation HPRD 19651622, 20068231, 18452278
S407 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S409 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 19415658
S410 Phosphorylation HPRD 17081983, 18452278, 19651622, ...18669648, 20166139, 19415658, 20068231
S419 Phosphorylation HPRD 17081983
S420 Phosphorylation HPRD 17081983
S451 Phosphorylation HPRD 18669648, 17081983
S452 Phosphorylation HPRD 17081983
S453 Phosphorylation HPRD 18669648, 17081983
S456 Phosphorylation HPRD 17081983
S459 Phosphorylation HPRD 17081983
T467 Phosphorylation HPRD 17081983
S469 Phosphorylation HPRD 17081983
S470 Phosphorylation HPRD 17081983
S471 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S451 Phosphorylation PhosphoSitePlus
S453 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation HPRD 20058876, 17081983, 20068231
Y50 Phosphorylation HPRD 20068231
S157 Phosphorylation HPRD 17322306, 18452278, 19651622, ...18669648, 20166139, 20068231
S327 Phosphorylation HPRD 17081983
S328 Phosphorylation HPRD 17081983
S331 Phosphorylation HPRD 17081983
S334 Phosphorylation HPRD 17081983
T335 Phosphorylation HPRD 17081983
S362 Phosphorylation HPRD 19651622, 20068231, 18452278
S407 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S409 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 19415658
S410 Phosphorylation HPRD 17081983, 18452278, 19651622, ...18669648, 20166139, 19415658, 20068231
S419 Phosphorylation HPRD 17081983
S420 Phosphorylation HPRD 17081983
S451 Phosphorylation HPRD 18669648, 17081983
S452 Phosphorylation HPRD 17081983
S453 Phosphorylation HPRD 18669648, 17081983
S456 Phosphorylation HPRD 17081983
S459 Phosphorylation HPRD 17081983
T467 Phosphorylation HPRD 17081983
S469 Phosphorylation HPRD 17081983
S470 Phosphorylation HPRD 17081983
S471 Phosphorylation HPRD 17081983
K710 Ubiquitination PhosphoSitePlus
K748 Ubiquitination PhosphoSitePlus
T749 Phosphorylation PhosphoSitePlus
S757 Phosphorylation PhosphoSitePlus
S759 Phosphorylation PhosphoSitePlus
K778 Ubiquitination PhosphoSitePlus
Y848 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:363 / uterine cancer [ icgc ]
S18 L18 Biomuta DOID:4159 / skin cancer [ cosmic ]
T39 M39 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T39 S39 Biomuta DOID:4159 / skin cancer [ cosmic ]
S65 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S92 Y92 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S92 F92 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S180 Y180 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S180 C180 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S189 L189 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ]
S228 L228 Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S274 R274 Biomuta [ cosmic ]
S331 C331 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S394 N394 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S394 R394 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K430 N430 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S456 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S469 R469 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S471 F471 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S476 L476 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S524 Y524 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S530 N530 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T560 S560 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
T749 A749 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y752 C752 Biomuta DOID:1324 / lung cancer [ cosmic ]
S757 R757 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
Y836 * Biomuta DOID:4159 / skin cancer [ cosmic ]