iPTMnet Report for P23471 (PTPRZ1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P23471 / PTPRZ_HUMAN
Protein Name Receptor-type tyrosine-protein phosphatase zeta precursor
Gene Name Name: PTPRZ1
Synonyms:HTPZP2,PTPRZ,PTPRZ2,PTPZ;
Organism Homo sapiens (Human)

PRO ID PR:P23471
DAG View
PRO Name receptor-type tyrosine-protein phosphatase zeta (human)
Definition A receptor-type tyrosine-protein phosphatase zeta that is encoded in the genome of human.
Short Label hPTPRZ1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23471 (PTPRZ1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y53 Phosphorylation PhosphoSitePlus
T55 Phosphorylation PhosphoSitePlus
K60 Acetylation PhosphoSitePlus
K78 Acetylation PhosphoSitePlus
N105 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 24190977
T107 O-Glycosylation GlyGen 28657654
N134 N-Glycosylation GlyGen 23090970, 24190977
S136 Phosphorylation PhosphoSitePlus
C264 Methylation IEDB 31844290
T479 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S482 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T484 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S600 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S604 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
N677 N-Glycosylation GlyGen 23090970, 24190977
S686 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T689 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T690 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T721 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T724 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
N1050 N-Glycosylation GlyGen 29671580
T1211 Phosphorylation PhosphoSitePlus
T1338 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S1339 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T1340 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S1396 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T1421 Phosphorylation PhosphoSitePlus
T1668 Phosphorylation PhosphoSitePlus
Y1672 Phosphorylation PhosphoSitePlus
T1687 Phosphorylation PhosphoSitePlus
T1998 Phosphorylation PhosphoSitePlus
S2031 Phosphorylation PhosphoSitePlus
T2054 Phosphorylation PhosphoSitePlus
S2055 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y2179 Phosphorylation PhosphoSitePlus
S2199 Phosphorylation PhosphoSitePlus
Y2276 Phosphorylation PhosphoSitePlus
S2281 Phosphorylation PhosphoSitePlus
S2284 Phosphorylation PhosphoSitePlus
T2285 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N1050 N-Glycosylation PRO 29671580
T2285 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K78 R78 Biomuta DOID:1324 / lung cancer [ cosmic ]
N105 S105 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
C264 S264 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S482 F482 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S604 F604 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S686 Y686 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T689 A689 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1211 S1211 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1339 C1339 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1339 Y1339 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y1672 C1672 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S2055 Y2055 Biomuta DOID:9256 / colorectal cancer [ cosmic ]