iPTMnet Report for P23469 (PTPRE)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P23469 / PTPRE_HUMAN
Protein Name Receptor-type tyrosine-protein phosphatase epsilon precursor
Gene Name Name: PTPRE
Organism Homo sapiens (Human)

PRO ID PR:P23469
DAG View
PRO Name receptor-type tyrosine-protein phosphatase epsilon (human)
Definition A receptor-type tyrosine-protein phosphatase epsilon that is encoded in the genome of human.
Short Label hPTPRE
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23469 (PTPRE) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S80 Phosphorylation PhosphoSitePlus
T81 Phosphorylation PhosphoSitePlus
K84 Acetylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
Y165 Phosphorylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K226 Methylation PhosphoSitePlus
K237 Methylation PhosphoSitePlus
K423 Acetylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
T434 Phosphorylation PhosphoSitePlus
K440 Acetylation PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus
K454 Acetylation PhosphoSitePlus
K651 Ubiquitination PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
S664 Phosphorylation PhosphoSitePlus
S694 Phosphorylation PhosphoSitePlus
Y696 Phosphorylation PhosphoSitePlus   UniProt 19690332
K700 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y696 Phosphorylation HPRD 17016520, 10490839
Site PTM Type PTM Enzyme Score Source PMID
R9 Methylation PhosphoSitePlus
K382 Acetylation PhosphoSitePlus
K396 Acetylation PhosphoSitePlus
Y638 Phosphorylation HPRD   PhosphoSitePlus 17016520, 10490839
K642 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S80 N80 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S174 F174 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
K199 N199 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K226 R226 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K651 R651 Biomuta DOID:1540 / parathyroid carcinoma [ cosmic ]