iPTMnet Report for P23467 (PTPRB)
Protein Information
UniProt AC / UniProt ID | P23467 / PTPRB_HUMAN |
Protein Name | Receptor-type tyrosine-protein phosphatase beta precursor |
Gene Name | Name: PTPRB Synonyms:PTPB; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P23467 |
PRO Name | receptor-type tyrosine-protein phosphatase beta (human) |
Definition | A receptor-type tyrosine-protein phosphatase beta that is encoded in the genome of human. |
Short Label | hPTPRB |
Category | organism-gene |
P23467 (PTPRB) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S3 | Phosphorylation | score1 | PhosphoSitePlus | |||
T62 | Phosphorylation | score1 | PhosphoSitePlus | |||
T201 | Phosphorylation | score1 | PhosphoSitePlus | |||
S204 | Phosphorylation | score1 | PhosphoSitePlus | |||
T465 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y531 | Phosphorylation | score1 | PhosphoSitePlus | |||
T534 | Phosphorylation | score1 | PhosphoSitePlus | |||
S537 | Phosphorylation | score1 | PhosphoSitePlus | |||
S539 | Phosphorylation | score1 | PhosphoSitePlus | |||
T605 | Phosphorylation | score1 | PhosphoSitePlus | |||
S606 | Phosphorylation | score1 | PhosphoSitePlus | |||
S698 | Phosphorylation | score1 | PhosphoSitePlus | |||
S701 | Phosphorylation | score1 | PhosphoSitePlus | |||
T709 | Phosphorylation | score1 | PhosphoSitePlus | |||
T711 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y719 | Phosphorylation | score1 | PhosphoSitePlus | |||
S723 | Phosphorylation | score1 | PhosphoSitePlus | |||
S725 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1008 | Phosphorylation | score1 | PhosphoSitePlus | |||
T1067 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 15144186 | ||
S1069 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 15144186 | ||
S1195 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y1209 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1314 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y1320 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y1328 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1647 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 17081983 | ||
S1666 | Phosphorylation | score1 | PhosphoSitePlus | |||
K1705 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y1733 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y1739 | Phosphorylation | score1 | PhosphoSitePlus | |||
T1742 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y1953 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y1955 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y1981 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 28385807 | ||
Y1988 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y1994 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y531 | Phosphorylation | score0 | HPRD | 18452278 | ||
T534 | Phosphorylation | score0 | HPRD | 18452278 | ||
S537 | Phosphorylation | score0 | HPRD | 18452278 | ||
S627 | Phosphorylation | score0 | HPRD | 15144186 | ||
T1067 | Phosphorylation | score0 | HPRD | 15144186 | ||
S1069 | Phosphorylation | score0 | HPRD | 15144186 | ||
S1647 | Phosphorylation | score0 | HPRD | 17081983 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S79 | Phosphorylation | score1 | PhosphoSitePlus | |||
S161 | Phosphorylation | score1 | PhosphoSitePlus | |||
T162 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y200 | Phosphorylation | score1 | PhosphoSitePlus | |||
S204 | Phosphorylation | score1 | PhosphoSitePlus | |||
S205 | Phosphorylation | score1 | PhosphoSitePlus |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | P08581 (MET) | Y1365 | P23467 (PTPRB) | unknown | eFIP | 16101282 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
Y531 | C531 | Biomuta | DOID:363 / uterine cancer [ tcga ] | |
Y531 | F531 | Biomuta | DOID:1909 / melanoma [ icgc, tcga ] | |
S539 | I539 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
T605 | N605 | Biomuta | DOID:3571 / liver cancer [ icgc ] | |
S698 | F698 | Biomuta | DOID:1909 / melanoma [ tcga ] | |
T709 | N709 | Biomuta | DOID:8618 / oral cavity cancer [ icgc ] | |
S725 | R725 | Biomuta | DOID:2994 / germ cell cancer [ cosmic ] | |
S1069 | N1069 | Biomuta | DOID:363 / uterine cancer [ tcga ] | |
Y1209 | H1209 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S1666 | C1666 | Biomuta | DOID:3070 / malignant glioma [ tcga ] | |
Y1953 | D1953 | Biomuta | DOID:1324 / lung cancer [ tcga ] |