Protein Information

Cytoscape View


UniProt AC / UniProt ID P23467 / PTPRB_HUMAN
Protein Name Receptor-type tyrosine-protein phosphatase beta precursor
Gene Name Name: PTPRB
Synonyms:PTPB;
Organism Homo sapiens (Human)

PRO ID PR:P23467
DAG View
PRO Name receptor-type tyrosine-protein phosphatase beta (human)
Definition A receptor-type tyrosine-protein phosphatase beta that is encoded in the genome of human.
Short Label hPTPRB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23467 (PTPRB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
T62 Phosphorylation PhosphoSitePlus
T201 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
T465 Phosphorylation PhosphoSitePlus
Y531 Phosphorylation PhosphoSitePlus
T534 Phosphorylation PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
T605 Phosphorylation PhosphoSitePlus
S606 Phosphorylation PhosphoSitePlus
S698 Phosphorylation PhosphoSitePlus
S701 Phosphorylation PhosphoSitePlus
T709 Phosphorylation PhosphoSitePlus
T711 Phosphorylation PhosphoSitePlus
Y719 Phosphorylation PhosphoSitePlus
S723 Phosphorylation PhosphoSitePlus
S725 Phosphorylation PhosphoSitePlus
S1008 Phosphorylation PhosphoSitePlus
T1067 Phosphorylation phospho.ELM   PhosphoSitePlus 15144186
S1069 Phosphorylation phospho.ELM   PhosphoSitePlus 15144186
S1195 Phosphorylation PhosphoSitePlus
Y1209 Phosphorylation PhosphoSitePlus
S1314 Phosphorylation PhosphoSitePlus
Y1320 Phosphorylation PhosphoSitePlus
Y1328 Phosphorylation PhosphoSitePlus
S1647 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S1666 Phosphorylation PhosphoSitePlus
K1705 Ubiquitination PhosphoSitePlus
Y1733 Phosphorylation PhosphoSitePlus
Y1739 Phosphorylation PhosphoSitePlus
T1742 Phosphorylation PhosphoSitePlus
Y1953 Phosphorylation PhosphoSitePlus
Y1955 Phosphorylation PhosphoSitePlus
Y1981 Phosphorylation PhosphoSitePlus   RLIMS-P 28385807
Y1988 Phosphorylation PhosphoSitePlus
Y1994 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y531 Phosphorylation HPRD 18452278
T534 Phosphorylation HPRD 18452278
S537 Phosphorylation HPRD 18452278
S627 Phosphorylation HPRD 15144186
T1067 Phosphorylation HPRD 15144186
S1069 Phosphorylation HPRD 15144186
S1647 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S79 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
T162 Phosphorylation PhosphoSitePlus
Y200 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P08581 (MET) Y1365 P23467 (PTPRB) unknown eFIP 16101282


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y531 C531 Biomuta DOID:363 / uterine cancer [ tcga ]
Y531 F531 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S539 I539 Biomuta DOID:1324 / lung cancer [ cosmic ]
T605 N605 Biomuta DOID:3571 / liver cancer [ icgc ]
S698 F698 Biomuta DOID:1909 / melanoma [ tcga ]
T709 N709 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
S725 R725 Biomuta DOID:2994 / germ cell cancer [ cosmic ]
S1069 N1069 Biomuta DOID:363 / uterine cancer [ tcga ]
Y1209 H1209 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1666 C1666 Biomuta DOID:3070 / malignant glioma [ tcga ]
Y1953 D1953 Biomuta DOID:1324 / lung cancer [ tcga ]