Protein Information

Cytoscape View


UniProt AC / UniProt ID P23458 / JAK1_HUMAN
Protein Name Tyrosine-protein kinase JAK1
Gene Name Name: JAK1
Synonyms:JAK1A,JAK1B;
Organism Homo sapiens (Human)

PRO ID PR:P23458
DAG View
PRO Name tyrosine-protein kinase JAK1 (human)
Definition A tyrosine-protein kinase JAK1 that is encoded in the genome of human.
Short Label hJAK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23458 (JAK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
M1 Acetylation UniProt 19369195
Y3 Phosphorylation PhosphoSitePlus   UniProt 19369195
K100 Ubiquitination PhosphoSitePlus
T119 Phosphorylation HPRD 20068231
S125 Phosphorylation HPRD 20068231
K142 Ubiquitination PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
Y217 Phosphorylation PhosphoSitePlus
Y220 Phosphorylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus   UniProt 19369195
K245 Ubiquitination PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
K269 Acetylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
Y412 Phosphorylation PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
Y507 Phosphorylation PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus   RLIMS-P 27919027
S518 Phosphorylation PhosphoSitePlus   RLIMS-P 27919027
S524 Phosphorylation PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
K559 Ubiquitination PhosphoSitePlus
Y568 Phosphorylation PhosphoSitePlus
S574 Phosphorylation PhosphoSitePlus
K581 Ubiquitination PhosphoSitePlus
Y605 Phosphorylation PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
T687 Phosphorylation HPRD   PhosphoSitePlus 18491316
T688 Phosphorylation HPRD   PhosphoSitePlus 18491316
K691 Ubiquitination PhosphoSitePlus
K696 Ubiquitination PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
K736 Ubiquitination PhosphoSitePlus
S738 Phosphorylation PhosphoSitePlus
K768 Ubiquitination PhosphoSitePlus
K802 Ubiquitination PhosphoSitePlus
K847 Ubiquitination PhosphoSitePlus
S857 Phosphorylation PhosphoSitePlus
K860 Ubiquitination PhosphoSitePlus
K872 Ubiquitination PhosphoSitePlus
K888 Ubiquitination PhosphoSitePlus
K908 Ubiquitination PhosphoSitePlus
S909 Phosphorylation PhosphoSitePlus
K911 Ubiquitination PhosphoSitePlus
K923 Ubiquitination PhosphoSitePlus
K924 Ubiquitination PhosphoSitePlus
K939 Ubiquitination PhosphoSitePlus
K941 Ubiquitination PhosphoSitePlus
Y967 Phosphorylation PhosphoSitePlus
K978 Ubiquitination PhosphoSitePlus
Y993 Phosphorylation PhosphoSitePlus
K1018 Ubiquitination PhosphoSitePlus
K1026 Ubiquitination PhosphoSitePlus
T1030 Phosphorylation PhosphoSitePlus
K1032 Ubiquitination PhosphoSitePlus
Y1034 Phosphorylation P52333 (JAK3) , P23458 (JAK1) HPRD   neXtProt   PRO   PhosphoSitePlus   UniProt 19901323, 12559972, 11909529, ...9382798
Y1035 Phosphorylation P23458 (JAK1) , P52333 (JAK3) HPRD   neXtProt   PhosphoSitePlus   UniProt 19901323, 12559972, 11909529
T1036 Phosphorylation PhosphoSitePlus
K1038 Ubiquitination PhosphoSitePlus
S1043 Phosphorylation PhosphoSitePlus
T1107 Phosphorylation HPRD   PhosphoSitePlus 18491316
K1109 Acetylation PhosphoSitePlus
K1109 Ubiquitination PhosphoSitePlus
K1112 Acetylation PhosphoSitePlus
Y1125 Phosphorylation PhosphoSitePlus
K1130 Ubiquitination PhosphoSitePlus


P23458 (JAK1) as PTM Enzyme



Substrate Site Score Source PMID
P14784 (IL2RB) Y364 HPRD 8700888
P15260 (IFNGR1) Y457 phospho.ELM   Signor 8156998, 7615558
P19525-1 (EIF2AK2) Y101 HPRD 17290288
P19525-1 (EIF2AK2) Y293 HPRD 17290288
P23458 (JAK1) Y1034 neXtProt   UniProt 9382798, 11909529
P23458 (JAK1) Y1035 UniProt 11909529
P29597 (TYK2) Y1054 HPRD   phospho.ELM   Signor 19901323, 30029643, 8702790
P29597 (TYK2) Y1055 HPRD   phospho.ELM   Signor 19901323, 8702790
P35568 (IRS1) Y612 HPRD 11162588
P35568 (IRS1) Y632 HPRD 11162588
P35568 (IRS1) Y662 HPRD 11162588
P35568 (IRS1) Y732 HPRD 11162588
P40763-2 (STAT3) Y704 HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095
P40763-1 (STAT3) Y705 HPRD   Signor 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 19723038, 17389395, 12626508, 11294897, 11940572, 12244095, 16497976
P42224-1 (STAT1) Y701 HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor 11438544, 10918587, 7657660, ...15322115, 7543024, 10982844, 11839738, 7504784, 12817007, 7690989, 11823427, 11294897, 12637327, 14978237
P52630-3 (STAT2) Y690 HPRD 9020188
Q13651 (IL10RA) Y446 HPRD 10433356
Q13651 (IL10RA) Y496 HPRD 10433356
Q99683 (MAP3K5) Y718 PhosphoSitePlus 19287004


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048083 (hJAK1/Phos:1) pY1034 PRO
PR:000048084 (hJAK1/PhosTyr+) p PRO