Protein Information

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UniProt AC / UniProt ID P23443 / KS6B1_HUMAN
Protein Name Ribosomal protein S6 kinase beta-1
Gene Name Name: RPS6KB1
Synonyms:STK14A;
Organism Homo sapiens (Human)

PRO ID PR:P23443
DAG View
PRO Name ribosomal protein S6 kinase beta-1 (human)
Definition A ribosomal protein S6 kinase beta-1 that is encoded in the genome of human.
Short Label hRPS6KB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23443 (RPS6KB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation PhosphoSitePlus
S53 Phosphorylation Q9HC98 (NEK6) phospho.ELM   PhosphoSitePlus 12023960
K85 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
T248 Phosphorylation PhosphoSitePlus
T250 Phosphorylation PhosphoSitePlus
T252 Phosphorylation P42336 (PIK3CA) , O15530 (PDPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9427642, 19864428, 26698305, ...25486532, 23119004, 9445476, 23830390, 10601311, 24605337, 11684675, 12183455
T256 Phosphorylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
K304 Acetylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
S371 Phosphorylation PRO
T389 Phosphorylation PRO
T390 Phosphorylation P42345 (MTOR) phospho.ELM   PhosphoSitePlus 11914378, 12370290, 9465032, ...18669648, 9271440, 14560963
S394 Phosphorylation P06493 (CDK1) , P42345 (MTOR) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 11914378, 14993219, 19085255, ...18669648, 12586835, 9271440
T399 Phosphorylation PhosphoSitePlus
S403 Phosphorylation Q9HC98 (NEK6) phospho.ELM   PhosphoSitePlus 12023960
T412 Phosphorylation O94768 (STK17B) , O15530 (PDPK1) , Q8TDX7 (NEK7) , Q9HC98 (NEK6) , P42336 (PIK3CA) , P42345 (MTOR) , P23443 (RPS6KB1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10579915, 10567431, 15388791, ...29750193, 15809305, 23830390, 11684675, 19864428, 12183455, 12023960, 19487463, 12370290, 20804212, 16099428, 19346248, 12558800, 9465032, 24605337, 15718470, 17386266, 11914378, 19342653, 12589797, 9445476, 11516946, 10601311
Y413 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
S421 Phosphorylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
S427 Phosphorylation phospho.ELM   PhosphoSitePlus 9271440
S434 Phosphorylation P06493 (CDK1) , P42345 (MTOR) , P45984 (MAPK9) , P27361 (MAPK3) , P45983 (MAPK8) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 19085255, 15809305, 11914378, ...17220300, 11279232, 15208671, 14993219, 14967450, 21035469, 12586835, 7545671, 11200472, 9271440, 11872747
S441 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 9271440, 18669648, 17081983, ...20068231
T444 Phosphorylation P06493 (CDK1) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 11705993, 23186163, 17081983, ...11914378, 19085255, 18669648, 12586835, 15774499, 11872747, 20068231
S447 Phosphorylation P28482 (MAPK1) , P06493 (CDK1) , P42345 (MTOR) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 23186163, 16964243, 21035469, ...14967450, 11914378, 19085255, 18669648, 12586835, 7545671, 11872747, 19690332, 20068231, 17081983
K450 Ubiquitination PhosphoSitePlus
S452 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S462 Phosphorylation PhosphoSitePlus
T470 Phosphorylation phospho.ELM   PhosphoSitePlus 9271440
K516 Acetylation PhosphoSitePlus
R522 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T252 Phosphorylation O15530 (PDPK1) HPRD 9271440, 9427642, 10601311
T390 Phosphorylation P42345 (MTOR) , Q15118 (PDK1) , P42336 (PIK3CA) HPRD 18669648, 11279232, 20068231
S394 Phosphorylation P42345 (MTOR) , P06493 (CDK1) HPRD 9271440, 18669648, 12586835
S398 Phosphorylation HPRD 20068231
T412 Phosphorylation O15530 (PDPK1) , P42345 (MTOR) HPRD 9271440, 12604610, 16899564, ...10601311
S427 Phosphorylation HPRD 9271440
S434 Phosphorylation P06493 (CDK1) HPRD 9271440, 12586835
S441 Phosphorylation HPRD   PRO 9271440, 18669648, 1922062, ...20068231
T444 Phosphorylation HPRD   PRO 18669648, 1922062, 20068231
S447 Phosphorylation HPRD   PRO 18669648, 1922062, 20068231, ...16964243
S452 Phosphorylation HPRD 19651622, 20068231
T470 Phosphorylation HPRD 9271440
Site PTM Type PTM Enzyme Score Source PMID
T229 Phosphorylation O15530 (PDPK1) PhosphoSitePlus 19570988
S371 Phosphorylation PhosphoSitePlus
T389 Phosphorylation P42345 (MTOR) PhosphoSitePlus 23928304
S418 Phosphorylation PhosphoSitePlus
T421 Phosphorylation PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus
K484 Acetylation PhosphoSitePlus
K485 Acetylation PhosphoSitePlus
K493 Acetylation PhosphoSitePlus


P23443 (RPS6KB1) as PTM Enzyme



Substrate Site Score Source PMID
O00418 (EEF2K) S366 HPRD   neXtProt   PhosphoSitePlus   Signor 14709557, 11500364, 15024086, ...11171059
O60825 (PFKFB2) S466 Signor 2846551, 9211863
O94763 (URI1) S372 neXtProt   PhosphoSitePlus 17936702
P03372 (ESR1) S167 neXtProt   PhosphoSitePlus   Signor 7838153, 19925796, 19112174
P04637 (TP53) S392 RLIMS-P+ 25429619
P04792 (HSPB1) S15 Signor 19593530
P04792 (HSPB1) S78 Signor 19593530
P04792 (HSPB1) S82 Signor 19593530
P08151 (GLI1) S84 PhosphoSitePlus   Signor 22439934
P10636-8 (MAPT) T212 HPRD   PhosphoSitePlus 16364302
P10636-8 (MAPT) S214 HPRD   PhosphoSitePlus 16364302
P10636-8 (MAPT) S262 HPRD   PhosphoSitePlus 16364302
P23443 (RPS6KB1) T412 PhosphoSitePlus 12183455
P23588-1 (EIF4B) S422 HPRD   neXtProt   PhosphoSitePlus   Signor 15071500, 16763566, 19664995, ...19651622, 18707149, 20068231, 17924679
P27708 (CAD) S1859 PhosphoSitePlus   Signor 23429703
P35568 (IRS1) S270 neXtProt   PhosphoSitePlus   Signor 9312143, 18952604
P35568 (IRS1) S307 neXtProt   PhosphoSitePlus   RLIMS-P+ 18952604, 16914728, 23565163
P35568 (IRS1) S527 PhosphoSitePlus   Signor 16914728
P35568 (IRS1) S636 neXtProt   PhosphoSitePlus 18952604
P35568 (IRS1) S1101 neXtProt   PhosphoSitePlus 17709744, 18952604, 16914728
P42345 (MTOR) T2446 neXtProt   PhosphoSitePlus   Signor 15905173, 12807916
P42345 (MTOR) S2448 HPRD   neXtProt   PhosphoSitePlus   Signor 15905173, 10910062, 19664994, ...15899889, 18691976
P49841 (GSK3B) S9 neXtProt   PhosphoSitePlus 7980435, 8250835, 8985174
P62753 (RPS6) S235 neXtProt   PhosphoSitePlus 17360704, 1737763
P62753 (RPS6) S236 neXtProt   PhosphoSitePlus 17360704, 1737763
P62753 (RPS6) S240 neXtProt   PhosphoSitePlus 17360704, 1737763
P62753 (RPS6) S244 neXtProt   PhosphoSitePlus 17360704, 1737763
P62753 (RPS6) S247 neXtProt 1737763
P78371 (CCT2) S260 PhosphoSitePlus   Signor 19332537
Q05195 (MXD1) S145 PhosphoSitePlus   Signor 18451027, 19526459
Q06787 (FMR1) S500 neXtProt   PhosphoSitePlus 24806451, 18474609
Q09161 (NCBP1) S7 PhosphoSitePlus 10973943
Q09161 (NCBP1) T21 PhosphoSitePlus 10973943
Q09161 (NCBP1) S22 PhosphoSitePlus 10973943
Q15831-1 (STK11) S428 HPRD 11853558, 11297520
Q16873 (LTC4S) S36 RLIMS-P+ 27365393
Q53EL6 (PDCD4) S67 neXtProt   PhosphoSitePlus   Signor 17053147, 18296647
Q6R327 (RICTOR) T1135 neXtProt   PhosphoSitePlus   Signor 19995915, 20832730, 19935711, ...19720745
Q8TB45 (DEPTOR) S286 PhosphoSitePlus   Signor 22017876
Q8TB45 (DEPTOR) S287 PhosphoSitePlus   Signor 22017876
Q8TB45 (DEPTOR) S291 PhosphoSitePlus   Signor 22017876
Q92519 (TRIB2) S83 PhosphoSitePlus 24089522
Q92934 (BAD) S99 neXtProt 11493700
Q9BY77 (POLDIP3) S383 neXtProt   PhosphoSitePlus   Signor 15341740
Q9BY77 (POLDIP3) S385 neXtProt   PhosphoSitePlus   Signor 15341740
Q9BYV9 (BACH2) S521 PhosphoSitePlus 17018862
Q9H3D4 (TP63) S477 Signor 18769144
Q9H3D4 (TP63) T491 Signor 18769144
Q9H3D4 (TP63) S560 PhosphoSitePlus   Signor 18769144
Q9UN36 (NDRG2) S332 PhosphoSitePlus 15461589
Q9UN36 (NDRG2) S350 PhosphoSitePlus 15461589


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049135 (hRPS6KB1/Phos:2) pS371,pT389 PRO
PR:000036480 (hRPS6KB1/iso:1/Phos:1) pS441,pT444,pS447 PRO 1922062


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S53 I53 Biomuta DOID:3571 / liver cancer [ icgc ]
K85 E85 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S398 T398 Biomuta DOID:3571 / liver cancer [ icgc ]
T412 A412 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S462 L462 Biomuta DOID:2394 / ovarian cancer [ tcga ]