Protein Information

Cytoscape View


UniProt AC / UniProt ID P23396 / RS3_HUMAN
Protein Name 40S ribosomal protein S3
Gene Name Name: RPS3
ORFNames:OK/SW-cl.26;
Organism Homo sapiens (Human)

PRO ID PR:P23396
DAG View
PRO Name 40S ribosomal protein S3 (human)
Definition A 40S ribosomal protein S3 that is encoded in the genome of human.
Short Label hRPS3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23396 (RPS3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 25944712
S6 Phosphorylation Q05655 (PRKCD) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19059439, 15950189, 28521470, ...20041225
K7 Ubiquitination PhosphoSitePlus
K8 Ubiquitination PhosphoSitePlus
K10 Acetylation PhosphoSitePlus
K10 Ubiquitination PhosphoSitePlus
K18 Sumoylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
R27 Methylation PhosphoSitePlus
Y34 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus   UniProt 23186163
T42 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20041225, 17560175, 15950189
T46 Phosphorylation PhosphoSitePlus
K62 Acetylation PhosphoSitePlus   UniProt 19608861
K62 Ubiquitination PhosphoSitePlus
R64 Methylation PhosphoSitePlus   UniProt 19460357
R65 Methylation PhosphoSitePlus   UniProt 19460357
R67 Methylation PhosphoSitePlus   UniProt 19460357
T70 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 20605787
K75 Acetylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
Y87 Phosphorylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
C97 S-Nitrosylation dbSNO 25040305, 26338901, 22178444, ...20140087
S104 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y107 Phosphorylation PhosphoSitePlus
K108 Acetylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
C119 S-Nitrosylation dbSNO 26338901
Y120 Phosphorylation PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
C134 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
S139 Phosphorylation PhosphoSitePlus
K141 Sumoylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
Y166 Phosphorylation PhosphoSitePlus
Y167 Phosphorylation PhosphoSitePlus
T170 Phosphorylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K197 Acetylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
S209 Phosphorylation O14920 (IKBKB) IntAct   PhosphoSitePlus   UniProt 21399639
K214 Acetylation PhosphoSitePlus
K214 Sumoylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus   UniProt 28065601, 28132843
T220 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18847512
T221 Phosphorylation P06493 (CDK1) , Q05655 (PRKCD) , P28482 (MAPK1) , P24941 (CDK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19059439, 21406692, 22028470, ...17287340, 16964243, 20041225, 18847512, 15302935, 19690332, 18669648, 24275569, 23186163, 21871177, 28521470, 20068231
S224 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16807684
K227 Ubiquitination PhosphoSitePlus
K230 Sumoylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
T242 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 24275569
Site PTM Type PTM Enzyme Score Source PMID
T220 Phosphorylation HPRD 19413330, 18691976, 17081983, ...20230923, 20058876, 19664994, 19664995, 19691289, 19651622, 18669648, 19415658, 20068231
T221 Phosphorylation HPRD 18578522, 15302935, 18707149, ...18452278, 18691976, 18212344, 20230923, 19691289, 16565220, 19413330, 18767875, 20058876, 19007248, 19651622, 18491316, 17287340, 19664994, 19664995, 18669648, 19415658, 20068231, 17924679
S224 Phosphorylation HPRD 18691976, 18669648, 17081983, ...20068231, 20230923
T242 Phosphorylation HPRD 18691976, 18669648


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P23396 (RPS3) S209 O14920 (IKBKB) unknown eFIP 21399639


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R27 W27 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K132 N132 Biomuta DOID:1324 / lung cancer [ cosmic ]
C134 F134 Biomuta DOID:3571 / liver cancer [ icgc ]
K151 N151 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T170 I170 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K202 N202 Biomuta DOID:3571 / liver cancer [ icgc ]