iPTMnet Report P23396 RPS3

Protein Information

UniProt AC / UniProt ID	P23396 / RS3_HUMAN
Protein Name	Small ribosomal subunit protein uS3
Gene Name	Name: RPS3 ORFNames:OK/SW-cl.26;
Organism	Homo sapiens (Human)

PRO ID	PR:P23396 DAG View
PRO Name	40S ribosomal protein S3 (human)
Definition	A 40S ribosomal protein S3 that is encoded in the genome of human.
Short Label	hRPS3
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P23396 (RPS3) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position A2 S6 K7 K8 K10 K18 R27 Y34 S35 T42 T46 K62 R64 R65 R67 T70 K75 S83 Y87 K90 C97 S104 Y107 K108 C119 Y120 K132 C134 S139 K141 S149 K151 S160 N165 Y166 Y167 T170 K185 K187 K197 K201 K202 S209 K214 T220 T221 S224 K227 K230 T242	PTM Type Select all Acetylation Methylation N-Glycosylation Phosphorylation S-Nitrosylation Sumoylation Ubiquitination	PTM Enzyme	Score Select all 0 1 2 3 4	Source Select all GlyGen IEDB IntAct PhosphoSitePlus RLIMS-P Signor UniProt dbSNO neXtProt phospho.ELM	PMID
A2	Acetylation		score1	UniProt	19413330, 22814378, 25944712
S6	Phosphorylation	Q05655 (PRKCD)	score4	neXtProt PhosphoSitePlus RLIMS-P Signor UniProt	20041225, 15950189, 28521470, ...19059439
K7	Ubiquitination		score1	PhosphoSitePlus
K8	Ubiquitination		score1	PhosphoSitePlus
K10	Acetylation		score1	PhosphoSitePlus
K10	Ubiquitination		score1	PhosphoSitePlus
K18	Sumoylation		score1	PhosphoSitePlus
K18	Ubiquitination		score1	PhosphoSitePlus
R27	Methylation		score1	PhosphoSitePlus
Y34	Phosphorylation		score1	PhosphoSitePlus
S35	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
T42	Phosphorylation	P27361 (MAPK3) , P28482 (MAPK1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	20041225, 17560175, 15950189
T46	Phosphorylation		score1	PhosphoSitePlus
K62	Acetylation		score2	PhosphoSitePlus UniProt	19608861
K62	Ubiquitination		score1	PhosphoSitePlus
R64	Methylation		score3	PhosphoSitePlus UniProt	19460357
R65	Methylation		score3	PhosphoSitePlus UniProt	19460357
R67	Methylation		score3	PhosphoSitePlus UniProt	19460357
T70	Phosphorylation	P31749 (AKT1)	score3	neXtProt PhosphoSitePlus RLIMS-P UniProt	20605787
K75	Acetylation		score1	PhosphoSitePlus
K75	Ubiquitination		score1	PhosphoSitePlus
S83	Phosphorylation		score1	PhosphoSitePlus
Y87	Phosphorylation		score1	PhosphoSitePlus
K90	Ubiquitination		score1	PhosphoSitePlus
C97	Methylation		score1	IEDB	31844290
C97	S-Nitrosylation		score0	dbSNO	25040305, 26338901, 22178444, ...20140087
S104	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
Y107	Phosphorylation		score1	PhosphoSitePlus
K108	Acetylation		score1	PhosphoSitePlus
K108	Ubiquitination		score1	PhosphoSitePlus
C119	Methylation		score1	IEDB	31844290
C119	S-Nitrosylation		score0	dbSNO	26338901
Y120	Phosphorylation		score1	PhosphoSitePlus
K132	Ubiquitination		score1	PhosphoSitePlus
C134	Methylation		score1	IEDB	31844290
C134	S-Nitrosylation		score0	dbSNO	2212679, 22126794, 26338901
S139	Phosphorylation		score1	PhosphoSitePlus
K141	Sumoylation		score1	PhosphoSitePlus
K141	Ubiquitination		score1	PhosphoSitePlus
S149	Phosphorylation		score1	PhosphoSitePlus
K151	Ubiquitination		score1	PhosphoSitePlus
S160	Phosphorylation		score1	PhosphoSitePlus
N165	N-Glycosylation		score2	GlyGen	27384988
Y166	Phosphorylation		score1	PhosphoSitePlus
Y167	Phosphorylation		score1	PhosphoSitePlus
T170	Phosphorylation		score1	PhosphoSitePlus
K185	Ubiquitination		score1	PhosphoSitePlus
K187	Ubiquitination		score1	PhosphoSitePlus
K197	Acetylation		score1	PhosphoSitePlus
K197	Ubiquitination		score1	PhosphoSitePlus
K201	Ubiquitination		score1	PhosphoSitePlus
K202	Ubiquitination		score1	PhosphoSitePlus
S209	Phosphorylation	O14920 (IKBKB)	score3	IntAct PhosphoSitePlus UniProt	21399639
K214	Acetylation		score1	PhosphoSitePlus
K214	Sumoylation		score1	PhosphoSitePlus
K214	Ubiquitination		score4	PhosphoSitePlus UniProt	28065601, 34469731, 28132843, ...34348161, 31981475, 32011234
T220	Phosphorylation	P24941 (CDK2)	score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163, 18847512
T221	Phosphorylation	P06493 (CDK1) , Q05655 (PRKCD) , P28482 (MAPK1) , P24941 (CDK2)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	19059439, 21406692, 22028470, ...23186163, 16964243, 20041225, 18847512, 15302935, 28521470, 18669648, 24275569, 17287340, 21871177, 19690332, 20068231
S224	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	16807684, 18669648
K227	Ubiquitination		score1	PhosphoSitePlus
K230	Sumoylation		score1	PhosphoSitePlus
K230	Ubiquitination		score1	PhosphoSitePlus
T242	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18691976, 18669648, 24275569

Search:

Site Select all By amino acid All Serine All Threonine By position T220 T221 S224 T242	PTM Type Select all Phosphorylation	Score Select all 0	Source Select all HPRD	PMID
T220	Phosphorylation	score0	HPRD	19413330, 18691976, 17081983, ...20230923, 20058876, 19664994, 19664995, 19691289, 19651622, 18669648, 19415658, 20068231
T221	Phosphorylation	score0	HPRD	18578522, 15302935, 18707149, ...18452278, 18691976, 18212344, 20230923, 19691289, 16565220, 19413330, 18767875, 20058876, 19007248, 19651622, 18491316, 17287340, 19664994, 19664995, 18669648, 19415658, 20068231, 17924679
S224	Phosphorylation	score0	HPRD	18691976, 18669648, 17081983, ...20068231, 20230923
T242	Phosphorylation	score0	HPRD	18691976, 18669648

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine By position A2 S104 K132 K151 T170 S209	Variant Select all I170 N132 N151 N209 S2 Y104	Source Select all Biomuta	Disease [Sample source] Select all DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
A2	S2	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
S104	Y104	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
K132	N132	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K151	N151	Biomuta	DOID:3571 / liver cancer [ cosmic ]
T170	I170	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
S209	N209	Biomuta	DOID:1319 / brain cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P23396 (RPS3)

Protein Information

Interactive Sequence View

P23396 (RPS3) as Substrate

PTM sites affected in variants