iPTMnet Report for P23378 (GLDC)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P23378 / GCSP_HUMAN
Protein Name Glycine dehydrogenase (decarboxylating), mitochondrial precursor
Gene Name Name: GLDC
Synonyms:GCSP;
Organism Homo sapiens (Human)

PRO ID PR:P23378
DAG View
PRO Name glycine dehydrogenase (decarboxylating), mitochondrial (human)
Definition A glycine dehydrogenase (decarboxylating), mitochondrial that is encoded in the genome of human.
Short Label hGLDC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23378 (GLDC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S38 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18088087
S39 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18088087
C225 S-Nitrosylation dbSNO 24105792
K272 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K423 Acetylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K514 Acetylation PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
Y537 Phosphorylation PhosphoSitePlus
K544 Ubiquitination PhosphoSitePlus
K636 Ubiquitination PhosphoSitePlus
K648 Acetylation PhosphoSitePlus
K664 Acetylation PhosphoSitePlus
K672 Acetylation PhosphoSitePlus
K672 Ubiquitination PhosphoSitePlus
S711 Phosphorylation IEDB 35494241
K773 Acetylation PhosphoSitePlus
K774 Ubiquitination PhosphoSitePlus
K789 Acetylation PhosphoSitePlus
K789 Ubiquitination PhosphoSitePlus
T830 Phosphorylation PhosphoSitePlus
T832 Phosphorylation PhosphoSitePlus
Y839 Phosphorylation PhosphoSitePlus
K871 Acetylation PhosphoSitePlus
K872 Acetylation PhosphoSitePlus
S873 Phosphorylation PhosphoSitePlus
K883 Acetylation PhosphoSitePlus
K883 Ubiquitination PhosphoSitePlus
S925 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K272 N272 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T830 M830 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ]
T830 K830 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K871 N871 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S925 I925 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]