iPTMnet Report for P23229 (ITGA6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P23229 / ITA6_HUMAN
Protein Name Integrin alpha-6 precursor
Gene Name Name: ITGA6
Organism Homo sapiens (Human)

PRO ID PR:P23229
DAG View
PRO Name integrin alpha-6 (human)
Definition An integrin alpha-6 that is encoded in the genome of human.
Short Label hITGA6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P23229 (ITGA6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S13 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
C86 S-Nitrosylation dbSNO 20140087, 22178444
T89 Phosphorylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
C131 S-Nitrosylation dbSNO 20140087, 22178444
K184 Ubiquitination PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
Y202 Phosphorylation PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
N323 N-Glycosylation GlyGen   UniProt 16263699, 23090970, 24190977, ...29741879
Y379 Phosphorylation PhosphoSitePlus
S452 O-Glycosylation GlyGen 33214551, 33465208, 34019948
T512 Phosphorylation PhosphoSitePlus
K525 Ubiquitination PhosphoSitePlus
C541 S-Nitrosylation dbSNO 20140087, 22178444
T560 Phosphorylation PhosphoSitePlus
T588 Phosphorylation PhosphoSitePlus
T592 Phosphorylation PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus
S632 Phosphorylation PhosphoSitePlus
S648 Phosphorylation PhosphoSitePlus
K690 Ubiquitination PhosphoSitePlus
K698 Ubiquitination PhosphoSitePlus
T716 Phosphorylation PhosphoSitePlus
S722 Phosphorylation PhosphoSitePlus
N726 N-Glycosylation GlyGen 24190977
K738 Ubiquitination PhosphoSitePlus
T742 Phosphorylation PhosphoSitePlus
S750 Phosphorylation PhosphoSitePlus
Y752 Phosphorylation PhosphoSitePlus
N770 N-Glycosylation GlyGen 23090970, 29741879, 24190977
T825 Phosphorylation PhosphoSitePlus
K827 Ubiquitination PhosphoSitePlus
Y871 Phosphorylation PhosphoSitePlus
T887 Phosphorylation PhosphoSitePlus
T889 Phosphorylation PhosphoSitePlus
N891 N-Glycosylation GlyGen 24190977
S899 Phosphorylation PhosphoSitePlus
K902 Ubiquitination PhosphoSitePlus
N927 N-Glycosylation GlyGen 24190977
N930 N-Glycosylation GlyGen 23090970, 24190977
T932 Phosphorylation PhosphoSitePlus
S934 Phosphorylation PhosphoSitePlus
S937 Phosphorylation PhosphoSitePlus
K939 Ubiquitination PhosphoSitePlus
N951 N-Glycosylation GlyGen 24190977
S955 Phosphorylation PhosphoSitePlus
N966 N-Glycosylation GlyGen 23090970, 29741879, 24190977
K986 Ubiquitination PhosphoSitePlus
N997 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...24190977
Y1009 Phosphorylation PhosphoSitePlus
S1043 Phosphorylation PhosphoSitePlus
T1045 Phosphorylation PhosphoSitePlus
V1059 Phosphorylation UniProt 8360143
G1064 Phosphorylation UniProt 8360143
K1100 Acetylation PhosphoSitePlus
R1103 Phosphorylation UniProt 8360143
Y1110 Phosphorylation PhosphoSitePlus
K1116 Ubiquitination PhosphoSitePlus
K1122 Ubiquitination PhosphoSitePlus
Y1129 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N997 N-Glycosylation PRO 29741879
Site PTM Type PTM Enzyme Score Source PMID
S446 Phosphorylation HPRD 20068231
T460 Phosphorylation HPRD 20068231
S1004 Phosphorylation PhosphoSitePlus
Y1050 Phosphorylation PhosphoSitePlus
T1053 Phosphorylation PhosphoSitePlus
Y1054 Phosphorylation PhosphoSitePlus
K1056 Ubiquitination PhosphoSitePlus
S1064 Phosphorylation HPRD   PhosphoSitePlus 20166139, 18691976, 18578522
K1066 Ubiquitination PhosphoSitePlus
T1070 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S446 Phosphorylation HPRD 20068231
T460 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y202 H202 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K525 E525 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S648 L648 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T887 K887 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
N930 D930 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K939 E939 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
N951 D951 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S955 Y955 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S955 A955 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K986 Q986 Biomuta DOID:363 / uterine cancer [ icgc ]
S1043 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
S1043 L1043 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
R1103 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]