Protein Information

Cytoscape View

UniProt AC / UniProt ID P23141 / EST1_HUMAN
Protein Name Liver carboxylesterase 1 precursor
Gene Name Name: CES1
Organism Homo sapiens (Human)

PRO ID PR:P23141
DAG View
PRO Name liver carboxylesterase 1 (human)
Definition A liver carboxylesterase 1 that is encoded in the genome of human.
Short Label hCES1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P23141 (CES1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
N79 N-Glycosylation GlyGen   UniProt 29741879, 12022871
Y83 Phosphorylation PhosphoSitePlus
T88 Phosphorylation PhosphoSitePlus
K302 Acetylation PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus   UniProt 24275569
K393 Ubiquitination PhosphoSitePlus
K402 Acetylation PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
Y403 Phosphorylation PhosphoSitePlus
T407 Phosphorylation PhosphoSitePlus
T444 Phosphorylation PhosphoSitePlus
S493 Phosphorylation PhosphoSitePlus
Y526 Phosphorylation PhosphoSitePlus
K538 Acetylation PhosphoSitePlus
K558 Acetylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y83 C83 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K302 * Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S380 P380 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K393 N393 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10283 / prostate cancer [ cosmic ]
K402 * Biomuta DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
T407 I407 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T407 K407 Biomuta DOID:1324 / lung cancer [ cosmic ]