iPTMnet Report for P22736 (NR4A1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P22736 / NR4A1_HUMAN
Protein Name Nuclear receptor subfamily 4immunitygroup A member 1
Gene Name Name: NR4A1
Synonyms:GFRP1,HMR,NAK1;
Organism Homo sapiens (Human)

PRO ID PR:P22736
DAG View
PRO Name nuclear receptor subfamily 4 group A member 1 (human)
Definition A nuclear receptor subfamily 4 group A member 1 that is encoded in the genome of human.
Short Label hNR4A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P22736 (NR4A1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T10 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
T27 Phosphorylation PhosphoSitePlus
T48 Phosphorylation PhosphoSitePlus   RLIMS-P 26155943
S52 Phosphorylation PhosphoSitePlus   RLIMS-P 26155943
S54 Phosphorylation PhosphoSitePlus   RLIMS-P 26155943
T55 Phosphorylation PhosphoSitePlus   RLIMS-P 26155943
Y60 Phosphorylation PhosphoSitePlus   RLIMS-P 26155943
T61 Phosphorylation PhosphoSitePlus   RLIMS-P 26155943
S95 Phosphorylation P45983 (MAPK8) neXtProt   PhosphoSitePlus   Signor 17023523
K102 Sumoylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
T143 Phosphorylation PhosphoSitePlus
S152 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P 22789442
S193 Phosphorylation PhosphoSitePlus
T196 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
K300 Sumoylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
T339 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
S351 Phosphorylation Q15418 (RPS6KA1) , P51812 (RPS6KA3) , O75582 (RPS6KA5) , P31749 (AKT1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 33235235, 17360704, 11274386, ...18669648, 16223362, 14525795, 16434970
S360 Phosphorylation PhosphoSitePlus
T366 Phosphorylation PhosphoSitePlus
K381 Sumoylation PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
S431 Phosphorylation P28482 (MAPK1) PhosphoSitePlus 22002310
K536 Ubiquitination PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
K577 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T143 Phosphorylation P28482 (MAPK1) HPRD 11883936
S201 Phosphorylation HPRD 18691976
S341 Phosphorylation HPRD 8227042
S351 Phosphorylation P51812 (RPS6KA3) , Q15418 (RPS6KA1) , P31749 (AKT1) , O75582 (RPS6KA5) HPRD 11274386, 18669648


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P10415 (BCL2) T56 P22736 (NR4A1) unknown eFIP 29050237


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S23 G23 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T27 A27 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S201 N201 Biomuta DOID:4159 / skin cancer [ cosmic ]
S201 R201 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K577 M577 Biomuta DOID:3571 / liver cancer [ cosmic ]