iPTMnet Report for P22695 (UQCRC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P22695 / QCR2_HUMAN
Protein Name Cytochrome b-c1 complex subunit 2, mitochondrial precursor
Gene Name Name: UQCRC2
Organism Homo sapiens (Human)

PRO ID PR:P22695
DAG View
PRO Name cytochrome b-c1 complex subunit 2, mitochondrial (human)
Definition A cytochrome b-c1 complex subunit 2, mitochondrial that is encoded in the genome of human.
Short Label hUQCRC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P22695 (UQCRC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation IEDB 27920218, 34171305
K17 Ubiquitination PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
K66 Acetylation PhosphoSitePlus
T86 Phosphorylation PhosphoSitePlus
T91 Phosphorylation HPRD 20068231
K92 Ubiquitination PhosphoSitePlus
K98 Methylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
T100 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
T113 Phosphorylation PhosphoSitePlus
C125 Methylation IEDB 31844290
K159 Ubiquitination PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
Y182 Phosphorylation PhosphoSitePlus
Y191 Phosphorylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
Y207 Phosphorylation PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
R241 Methylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
R254 Methylation PhosphoSitePlus
R301 Methylation PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
S367 O-Glycosylation GlyGen 23271734, 34725712, 35083852, ...29351928
S367 Phosphorylation PhosphoSitePlus
T369 O-Glycosylation GlyGen 23271734, 34725712, 35083852, ...29351928
T369 Phosphorylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K429 Acetylation PhosphoSitePlus
K430 Acetylation PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
T447 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K23 T23 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y55 F55 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y55 C55 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S59 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K98 N98 Biomuta DOID:3571 / liver cancer [ cosmic ]
K159 Q159 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K162 E162 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R301 K301 Biomuta DOID:1319 / brain cancer [ cosmic ]
S367 F367 Biomuta DOID:4159 / skin cancer [ cosmic ]
K429 N429 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K436 E436 Biomuta DOID:1612 / breast cancer [ cosmic ]