iPTMnet Report for P22694 (PRKACB)
Protein Information
| UniProt AC / UniProt ID | P22694 / KAPCB_HUMAN |
| Protein Name | cAMP-dependent protein kinase catalytic subunit beta |
| Gene Name | Name: PRKACB |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P22694 |
| PRO Name | cAMP-dependent protein kinase catalytic subunit beta (human) |
| Definition | A cAMP-dependent protein kinase catalytic subunit beta that is encoded in the genome of human. |
| Short Label | hPRKACB |
| Category | organism-gene |
DAG ViewP22694 (PRKACB) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| G2 | Myristoylation | score1 | UniProt | 25255805 | ||
| T6 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S11 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S15 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K17 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K24 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K30 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K47 | Acetylation | score1 | PhosphoSitePlus | |||
| K48 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T49 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T52 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S54 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K64 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y69 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y70 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K73 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K84 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T89 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K93 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y157 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y165 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y180 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T184 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T196 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T198 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T202 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y205 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K214 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S253 | O-Glycosylation | score3 | GlyGen | 30379171, 26840030 | ||
| K255 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S260 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S264 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K267 | Acetylation | score1 | PhosphoSitePlus | |||
| K267 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K280 | Acetylation | score1 | PhosphoSitePlus | |||
| K280 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K286 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K293 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K310 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K318 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S322 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T325 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S326 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y331 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S339 | Phosphorylation | score3 | neXtProt PhosphoSitePlus | 1460017 | ||
| S339 | Phosphorylation | P22694 (PRKACB) | score2 | neXtProt | 1460017 | |
| T341 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K343 | Ubiquitination | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T196 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T198 | Phosphorylation | score0 | HPRD | 20068231, 18452278 | ||
| S339 | Phosphorylation | score0 | HPRD | 20166139, 18691976 |
P22694 (PRKACB) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| P08138 (NGFR) | S303 | score3 | HPRD neXtProt PhosphoSitePlus Signor | 12682012 | |
| P22694 (PRKACB) | S339 | score2 | neXtProt | 1460017 | |
| P30518 (AVPR2) | S255 | score2 | neXtProt | 18578504 | |
| P43699 (NKX2-1) | T9 | score2 | neXtProt | 9211870 | |
| Q13185 (CBX3) | S93 | score2 | neXtProt | 16531993 | |
| Q14896 (MYBPC3) | S275 | score1 | Signor | 20151718 | |
| Q14896 (MYBPC3) | S284 | score1 | Signor | 20151718 | |
| Q14896 (MYBPC3) | S304 | score1 | Signor | 20151718 | |
| Q14896 (MYBPC3) | S311 | score1 | Signor | 20151718 | |
| Q6PIY7 (TENT2) | S116 | score1 | Signor | 31057087 | |
| Q92934 (BAD) | S75 | score1 | Signor | 10949026 | |
| Q92934 (BAD) | S99 | score1 | Signor | 10949026 | |
| Q92934 (BAD) | S118 | score1 | Signor | 10949026 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K24 | E24 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| K24 | T24 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| T49 | P49 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| T52 | R52 | Biomuta | DOID:169 / neuroendocrine tumor [ tcga ] | |
| K84 | N84 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| Y157 | C157 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S253 | T253 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S260 | F260 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K310 | N310 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S322 | C322 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S326 | G326 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| S326 | R326 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| Y331 | S331 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] |
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