iPTMnet Report for P22694 (PRKACB)
Protein Information
UniProt AC / UniProt ID | P22694 / KAPCB_HUMAN |
Protein Name | cAMP-dependent protein kinase catalytic subunit beta |
Gene Name | Name: PRKACB |
Organism | Homo sapiens (Human) |
PRO ID | PR:P22694 |
PRO Name | cAMP-dependent protein kinase catalytic subunit beta (human) |
Definition | A cAMP-dependent protein kinase catalytic subunit beta that is encoded in the genome of human. |
Short Label | hPRKACB |
Category | organism-gene |
P22694 (PRKACB) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
G2 | Myristoylation | score1 | UniProt | 25255805 | ||
T6 | Phosphorylation | score1 | PhosphoSitePlus | |||
S11 | Phosphorylation | score1 | PhosphoSitePlus | |||
S15 | Phosphorylation | score1 | PhosphoSitePlus | |||
K17 | Ubiquitination | score1 | PhosphoSitePlus | |||
K24 | Ubiquitination | score1 | PhosphoSitePlus | |||
K30 | Ubiquitination | score1 | PhosphoSitePlus | |||
K47 | Acetylation | score1 | PhosphoSitePlus | |||
K48 | Ubiquitination | score1 | PhosphoSitePlus | |||
T49 | Phosphorylation | score1 | PhosphoSitePlus | |||
T52 | Phosphorylation | score1 | PhosphoSitePlus | |||
S54 | Phosphorylation | score1 | PhosphoSitePlus | |||
K64 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y69 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y70 | Phosphorylation | score1 | PhosphoSitePlus | |||
K73 | Ubiquitination | score1 | PhosphoSitePlus | |||
K84 | Ubiquitination | score1 | PhosphoSitePlus | |||
T89 | Phosphorylation | score1 | PhosphoSitePlus | |||
K93 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y157 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y165 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y180 | Phosphorylation | score1 | PhosphoSitePlus | |||
T184 | Phosphorylation | score1 | PhosphoSitePlus | |||
T196 | Phosphorylation | score1 | PhosphoSitePlus | |||
T198 | Phosphorylation | score1 | PhosphoSitePlus | |||
T202 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y205 | Phosphorylation | score1 | PhosphoSitePlus | |||
K214 | Ubiquitination | score1 | PhosphoSitePlus | |||
S253 | O-Glycosylation | score3 | GlyGen | 30379171, 26840030 | ||
K255 | Ubiquitination | score1 | PhosphoSitePlus | |||
S260 | Phosphorylation | score1 | PhosphoSitePlus | |||
S264 | Phosphorylation | score1 | PhosphoSitePlus | |||
K267 | Acetylation | score1 | PhosphoSitePlus | |||
K267 | Ubiquitination | score1 | PhosphoSitePlus | |||
K280 | Acetylation | score1 | PhosphoSitePlus | |||
K280 | Ubiquitination | score1 | PhosphoSitePlus | |||
K286 | Ubiquitination | score1 | PhosphoSitePlus | |||
K293 | Ubiquitination | score1 | PhosphoSitePlus | |||
K310 | Ubiquitination | score1 | PhosphoSitePlus | |||
K318 | Ubiquitination | score1 | PhosphoSitePlus | |||
S322 | Phosphorylation | score1 | PhosphoSitePlus | |||
T325 | Phosphorylation | score1 | PhosphoSitePlus | |||
S326 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y331 | Phosphorylation | score1 | PhosphoSitePlus | |||
S339 | Phosphorylation | score3 | neXtProt PhosphoSitePlus | 1460017 | ||
S339 | Phosphorylation | P22694 (PRKACB) | score2 | neXtProt | 1460017 | |
T341 | Phosphorylation | score1 | PhosphoSitePlus | |||
K343 | Ubiquitination | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T196 | Phosphorylation | score0 | HPRD | 20068231 | ||
T198 | Phosphorylation | score0 | HPRD | 20068231, 18452278 | ||
S339 | Phosphorylation | score0 | HPRD | 20166139, 18691976 |
P22694 (PRKACB) as PTM Enzyme
Substrate | Site | Score | Source | PMID | |
---|---|---|---|---|---|
P08138 (NGFR) | S303 | score3 | HPRD neXtProt PhosphoSitePlus Signor | 12682012 | |
P22694 (PRKACB) | S339 | score2 | neXtProt | 1460017 | |
P30518 (AVPR2) | S255 | score2 | neXtProt | 18578504 | |
P43699 (NKX2-1) | T9 | score2 | neXtProt | 9211870 | |
Q13185 (CBX3) | S93 | score2 | neXtProt | 16531993 | |
Q14896 (MYBPC3) | S275 | score1 | Signor | 20151718 | |
Q14896 (MYBPC3) | S284 | score1 | Signor | 20151718 | |
Q14896 (MYBPC3) | S304 | score1 | Signor | 20151718 | |
Q14896 (MYBPC3) | S311 | score1 | Signor | 20151718 | |
Q6PIY7 (TENT2) | S116 | score1 | Signor | 31057087 | |
Q92934 (BAD) | S75 | score1 | Signor | 10949026 | |
Q92934 (BAD) | S99 | score1 | Signor | 10949026 | |
Q92934 (BAD) | S118 | score1 | Signor | 10949026 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K24 | E24 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
K24 | T24 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
T49 | P49 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
T52 | R52 | Biomuta | DOID:169 / neuroendocrine tumor [ tcga ] | |
K84 | N84 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
Y157 | C157 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S253 | T253 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S260 | F260 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K310 | N310 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S322 | C322 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
S326 | G326 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
S326 | R326 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
Y331 | S331 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] |