iPTMnet Report for P22680 (CYP7A1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P22680 / CP7A1_HUMAN
Protein Name Cytochrome P450 7A1
Gene Name Name: CYP7A1
Synonyms:CYP7;
Organism Homo sapiens (Human)

PRO ID PR:P22680
DAG View
PRO Name cytochrome P450 7A1 (human)
Definition A cytochrome P450 7A1 that is encoded in the genome of human.
Short Label hCYP7A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P22680 (CYP7A1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T4 Phosphorylation PhosphoSitePlus
Y176 Phosphorylation PhosphoSitePlus
T266 Phosphorylation HPRD   PhosphoSitePlus 20166139
S268 Phosphorylation HPRD   PhosphoSitePlus 20166139
T269 Phosphorylation HPRD   PhosphoSitePlus 20166139
Y432 Phosphorylation PhosphoSitePlus
Y433 Phosphorylation PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T4 I4 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S268 F268 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S268 Y268 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y432 C432 Biomuta DOID:3571 / liver cancer [ cosmic ]
S439 L439 Biomuta DOID:1324 / lung cancer [ cosmic ]