iPTMnet Report for P22626 (HNRNPA2B1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P22626 / ROA2_HUMAN
Protein Name Heterogeneous nuclear ribonucleoproteins A2/B1
Gene Name Name: HNRNPA2B1
Synonyms:HNRPA2B1;
Organism Homo sapiens (Human)

PRO ID PR:P22626
DAG View
PRO Name heterogeneous nuclear ribonucleoproteins A2/B1 (human)
Definition A heterogeneous nuclear ribonucleoproteins A2/B1 that is encoded in the genome of human.
Short Label hHNRNPA2B1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P22626 (HNRNPA2B1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K3 Acetylation PhosphoSitePlus
K3 Ubiquitination PhosphoSitePlus
T4 Phosphorylation PhosphoSitePlus   UniProt 23186163
T7 Phosphorylation PhosphoSitePlus
K13 Sumoylation PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
K22 Acetylation PhosphoSitePlus
K22 Sumoylation PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T32 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
R38 Methylation PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus
Y41 Phosphorylation PhosphoSitePlus
K46 Acetylation PhosphoSitePlus
K46 Methylation PhosphoSitePlus
K46 Sumoylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
T48 O-Glycosylation GlyGen 23576270, 30444036, 22322011, ...24126823, 30379171, 34725712, 30059200, 29351928, 31235510, 34019948, 35083852, 33214551, 31492838, 20305658, 32119511, 30620550, 22121020
T48 Phosphorylation PhosphoSitePlus
C50 Methylation IEDB 31844290
S58 Phosphorylation PhosphoSitePlus
K59 Acetylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus   UniProt 20068231, 19690332, 24275569
K94 Acetylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
K104 Acetylation PhosphoSitePlus
K104 Sumoylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
K112 Acetylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K113 Acetylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
K120 Acetylation PhosphoSitePlus
K120 Sumoylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
R129 Methylation PhosphoSitePlus
Y131 Phosphorylation PhosphoSitePlus
Y135 Phosphorylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
T140 Phosphorylation PhosphoSitePlus   UniProt 23186163
T145 Phosphorylation PhosphoSitePlus
R147 Methylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus   UniProt 20068231
K151 Sumoylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K152 Sumoylation PhosphoSitePlus
R153 Methylation PhosphoSitePlus
T159 Phosphorylation PhosphoSitePlus   UniProt 21851590, 23186163
T159 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
K168 Acetylation PhosphoSitePlus   UniProt 19608861
K168 Sumoylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K173 Acetylation PhosphoSitePlus   UniProt 19608861
K173 Sumoylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
Y174 Phosphorylation PhosphoSitePlus
T176 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 23186163
K186 Sumoylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus   UniProt 23186163
S198 O-Glycosylation GlyGen 31373491
S198 Phosphorylation PhosphoSitePlus
S199 O-Glycosylation GlyGen 23576270, 30444036, 22322011, ...24126823, 30379171, 34725712, 30059200, 29351928, 31235510, 34019948, 35083852, 33214551, 31492838, 20305658, 32119511, 30620550, 22121020
R200 Methylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus   UniProt 23186163
R203 Methylation PhosphoSitePlus   UniProt 24129315, 15782174
S212 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569, 17287340, 19690332, 20068231
R213 Methylation PhosphoSitePlus   UniProt 24129315
S225 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569, 20068231
R228 Methylation PhosphoSitePlus   UniProt 24129315, 31320558
S231 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231, 24275569
Y234 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus   UniProt 21406692
R238 Methylation PhosphoSitePlus   UniProt 24129315
Y244 Phosphorylation PhosphoSitePlus
Y247 Phosphorylation PhosphoSitePlus
S259 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 17287340, ...16964243, 18220336, 18691976, 18669648, 23186163, 19690332, 20068231, 17924679
Y262 Phosphorylation PhosphoSitePlus
R266 Methylation IEDB   PhosphoSitePlus   UniProt 28649982, 24129315
Y287 Phosphorylation PhosphoSitePlus
Y290 Phosphorylation PhosphoSitePlus
Y295 Phosphorylation PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
Y300 Phosphorylation PhosphoSitePlus
Y306 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
Y313 Phosphorylation PhosphoSitePlus
K317 Sumoylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
R325 Methylation PhosphoSitePlus   UniProt 24129315
Y331 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
Y336 Phosphorylation PhosphoSitePlus
S341 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 18669648, ...24275569, 17287340, 20068231, 17924679
S344 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 15302935, ...18669648, 24275569, 23186163, 19690332, 20068231
Y347 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 24275569
R350 Methylation PhosphoSitePlus   UniProt 24129315
S351 Phosphorylation PhosphoSitePlus
R352 Methylation PhosphoSitePlus
Y353 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO
S85 Phosphorylation HPRD 19651622, 20068231
S149 Phosphorylation HPRD 20068231
T176 Phosphorylation HPRD 17287340
S189 Phosphorylation HPRD 20068231, 18452278
S201 Phosphorylation HPRD 20068231
S212 Phosphorylation HPRD 20166139, 18669648, 17287340, ...18212344, 20068231
S225 Phosphorylation HPRD 18669648, 20068231
S231 Phosphorylation HPRD 20068231
Y244 Phosphorylation HPRD 20068231
S259 Phosphorylation HPRD 19413330, 18691976, 18491316, ...17287340, 16964243, 20058876, 19664995, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231, 17924679
Y262 Phosphorylation HPRD 19664995, 20068231
S324 Phosphorylation HPRD 20166139
S341 Phosphorylation HPRD 17287340, 15302935, 18452278, ...18669648, 20068231, 17924679
S344 Phosphorylation HPRD 19413330, 17287340, 15302935, ...19664995, 18452278, 19651622, 18669648, 19415658, 20068231
Y347 Phosphorylation HPRD 17287340
Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO
K5 Sumoylation PhosphoSitePlus
S73 Phosphorylation HPRD 19651622, 20068231
S137 Phosphorylation HPRD 20068231
T164 Phosphorylation HPRD 17287340
K174 Ubiquitination PhosphoSitePlus
S177 Phosphorylation HPRD 20068231, 18452278
S189 Phosphorylation HPRD 20068231
S200 Phosphorylation HPRD 20166139, 18669648, 17287340, ...18212344, 20068231
S213 Phosphorylation HPRD   PRO 18669648, 20068231
S219 Phosphorylation HPRD 20068231
Y232 Phosphorylation HPRD 20068231
S247 Phosphorylation HPRD 19413330, 18691976, 18491316, ...17287340, 16964243, 20058876, 19664995, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231, 17924679
Y250 Phosphorylation HPRD 19664995, 20068231
K305 Ubiquitination PhosphoSitePlus
S312 Phosphorylation HPRD 20166139
S329 Phosphorylation HPRD 17287340, 15302935, 18452278, ...18669648, 20068231, 17924679
S332 Phosphorylation HPRD 19413330, 17287340, 15302935, ...19664995, 18452278, 19651622, 18669648, 19415658, 20068231
Y335 Phosphorylation HPRD 17287340


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036253 (hHNRNPA2B1/Ac:1) acM1 PRO
PR:000044849 (hHNRNPA2B1/iso:A2/AcPhos:1) acM1 PRO
PR:000044849 (hHNRNPA2B1/iso:A2/AcPhos:1) pS213 PRO
PR:000044850 (hHNRNPA2B1/iso:A2/Ac:1) acM1 PRO
PR:000044851 (hHNRNPA2B1/iso:A2/AcMe1o:1) acM1 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S58 L58 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]