iPTMnet Report for P22607 (FGFR3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P22607 / FGFR3_HUMAN
Protein Name Fibroblast growth factor receptor 3 precursor
Gene Name Name: FGFR3
Synonyms:JTK4;
Organism Homo sapiens (Human)

PRO ID PR:P22607
DAG View
PRO Name fibroblast growth factor receptor 3 (human)
Definition A fibroblast growth factor receptor 3 that is encoded in the genome of human.
Short Label hFGFR3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P22607 (FGFR3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S249 Phosphorylation RLIMS-P 31316618
S408 Phosphorylation PhosphoSitePlus
T410 Phosphorylation PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus
S444 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S445 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T450 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S524 Phosphorylation PhosphoSitePlus
K530 Acetylation PhosphoSitePlus
Y577 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 11294897
Y577 Phosphorylation P22607 (FGFR3) phospho.ELM   Signor 11294897
S578 Phosphorylation PhosphoSitePlus
S596 Phosphorylation PhosphoSitePlus
Y599 Phosphorylation PhosphoSitePlus
Y607 Phosphorylation PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
Y647 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11294897, 8754806
Y647 Phosphorylation P22607 (FGFR3) phospho.ELM   PhosphoSitePlus   Signor   UniProt 11294897, 8754806
Y648 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11294897, 8754806
Y648 Phosphorylation P22607 (FGFR3) phospho.ELM   PhosphoSitePlus   Signor   UniProt 11294897, 8754806
Y724 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11294897, 29540697
Y724 Phosphorylation P22607 (FGFR3) phospho.ELM   PhosphoSitePlus   Signor   UniProt 11294897
Y760 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 11294897, 19286672
Y760 Phosphorylation P22607 (FGFR3) phospho.ELM   Signor   UniProt 11294897, 19286672
Y770 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 11294897
Y770 Phosphorylation P22607 (FGFR3) phospho.ELM   Signor 11294897
S771 Phosphorylation PhosphoSitePlus
T777 Phosphorylation PhosphoSitePlus
S787 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S444 Phosphorylation HPRD 18669648
S445 Phosphorylation HPRD 18669648
T450 Phosphorylation HPRD 18669648
Y577 Phosphorylation HPRD 19901323, 11294897
Y577 Phosphorylation P22607 (FGFR3) HPRD 19901323, 11294897
S578 Phosphorylation HPRD 19901323
Y647 Phosphorylation HPRD 19901323, 11294897
Y647 Phosphorylation P22607 (FGFR3) HPRD 19901323, 11294897
Y648 Phosphorylation HPRD 19901323, 11294897
Y648 Phosphorylation P22607 (FGFR3) HPRD 19901323, 11294897
Y724 Phosphorylation HPRD 19901323, 11294897
Y724 Phosphorylation P22607 (FGFR3) HPRD 19901323, 11294897
Y760 Phosphorylation HPRD 11294897
Y760 Phosphorylation P22607 (FGFR3) HPRD 11294897
Y770 Phosphorylation HPRD 11294897
Y770 Phosphorylation P22607 (FGFR3) HPRD 11294897
Site PTM Type PTM Enzyme Score Source PMID
S318 Phosphorylation PhosphoSitePlus
T323 Phosphorylation PhosphoSitePlus
S332 Phosphorylation HPRD 18669648
S333 Phosphorylation HPRD 18669648
T338 Phosphorylation HPRD 18669648
Y465 Phosphorylation HPRD 19901323, 11294897
Y465 Phosphorylation P22607 (FGFR3) HPRD 19901323, 11294897
S466 Phosphorylation HPRD 19901323
Y535 Phosphorylation HPRD 19901323, 11294897
Y535 Phosphorylation P22607 (FGFR3) HPRD 19901323, 11294897
Y536 Phosphorylation HPRD 19901323, 11294897
Y536 Phosphorylation P22607 (FGFR3) HPRD 19901323, 11294897
Y612 Phosphorylation HPRD 19901323, 11294897
Y612 Phosphorylation P22607 (FGFR3) HPRD 19901323, 11294897
Y648 Phosphorylation HPRD 11294897
Y648 Phosphorylation P22607 (FGFR3) HPRD 11294897
Y658 Phosphorylation HPRD 11294897
Y658 Phosphorylation P22607 (FGFR3) HPRD 11294897


P22607 (FGFR3) as PTM Enzyme



Substrate Site Score Source PMID
P22607-3 (FGFR3) Y465 HPRD 19901323, 11294897
P22607-3 (FGFR3) Y535 HPRD 19901323, 11294897
P22607-3 (FGFR3) Y536 HPRD 19901323, 11294897
P22607-1 (FGFR3) Y577 HPRD   phospho.ELM   Signor 19901323, 11294897
P22607-3 (FGFR3) Y612 HPRD 19901323, 11294897
P22607 (FGFR3) Y647 HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19901323, 11294897, 8754806
P22607-1 (FGFR3) Y648 HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19901323, 11294897, 8754806
P22607-3 (FGFR3) Y658 HPRD 11294897
P22607-1 (FGFR3) Y724 HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19901323, 11294897
P22607-1 (FGFR3) Y760 HPRD   phospho.ELM   Signor   UniProt 11294897, 19286672
P22607-1 (FGFR3) Y770 HPRD   phospho.ELM   Signor 11294897
P35222 (CTNNB1) Y142 PhosphoSitePlus 22558232
P40763-2 (STAT3) Y704 HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095
P40763-1 (STAT3) Y705 HPRD   Signor 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095, 16497976
P42224-2 (STAT1) Y701 HPRD   PhosphoSitePlus   Signor 10918587, 7657660, 15322115, ...7543024, 11839738, 12817007, 7690989, 19088846, 11294897, 12637327
P51812 (RPS6KA3) Y488 PhosphoSitePlus 17785202
P51812 (RPS6KA3) Y529 neXtProt   PhosphoSitePlus   RLIMS-P+ 19223461, 17785202, 18156174
P51812 (RPS6KA3) Y707 RLIMS-P+ 19223461
P60484 (PTEN) Y240 PhosphoSitePlus   Signor 22891331


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S249 Y249 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S249 T249 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S249 C249 Biomuta DOID:3277 / thymus cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:1245 / vulva cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:2394 / ovarian cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S249 F249 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T323 K323 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S332 F332 Biomuta DOID:4159 / skin cancer [ cosmic ]
T338 M338 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3565 / meningioma [ cosmic ]
T410 A410 Biomuta DOID:1964 / fallopian tube cancer [ cosmic ]
T410 I410 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K413 N413 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K413 E413 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S424 F424 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S444 F444 Biomuta DOID:4159 / skin cancer [ cosmic ]
T450 M450 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3565 / meningioma [ cosmic ]
S466 F466 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3565 / meningioma [ cosmic ]
K530 N530 Biomuta DOID:3571 / liver cancer [ cosmic ]
S578 F578 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3565 / meningioma [ cosmic ]
T777 N777 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S787 F787 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]