iPTMnet Report for P22492 (H1-6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P22492 / H1T_HUMAN
Protein Name Histone H1t
Gene Name Name: H1-6
Synonyms:H1FT,H1T,HIST1H1T;
Organism Homo sapiens (Human)

PRO ID PR:P22492
DAG View
PRO Name histone H1t (human)
Definition A histone H1t that is encoded in the genome of human.
Short Label hH1-6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P22492 (H1-6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T22 Phosphorylation PhosphoSitePlus
K68 Sumoylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
Y75 Phosphorylation PhosphoSitePlus
K79 Acetylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
T103 Phosphorylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
K110 Acetylation PhosphoSitePlus
K113 Acetylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
T149 Phosphorylation PhosphoSitePlus
T159 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
T160 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
K162 Acetylation PhosphoSitePlus
K171 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y75 N75 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T103 A103 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S106 Y106 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S143 L143 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T149 N149 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]