iPTMnet Report for P22460 (KCNA5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P22460 / KCNA5_HUMAN
Protein Name Potassium voltage-gated channel subfamily A member 5
Gene Name Name: KCNA5
Organism Homo sapiens (Human)

PRO ID PR:P22460
DAG View
PRO Name potassium voltage-gated channel subfamily A member 5 (human)
Definition A voltage-gated potassium channel subunit KCNA5 that is encoded in the genome of human.
Short Label hKCNA5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P22460 (KCNA5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T15 Phosphorylation PhosphoSitePlus   RLIMS-P 16466689
T15 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 16466689
S62 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
Y203 Phosphorylation PhosphoSitePlus
K221 Sumoylation PhosphoSitePlus
C331 S-Nitrosylation dbSNO 16876149, 22178444
C346 S-Nitrosylation dbSNO 16876149, 22178444
S414 Phosphorylation PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
K536 Sumoylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus
S592 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S414 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T15 I15 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S192 F192 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C331 Y331 Biomuta DOID:1324 / lung cancer [ cosmic ]
C346 S346 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S414 Y414 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S414 P414 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:2174 / ocular cancer [ cosmic ]
S498 L498 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ]