iPTMnet Report for P22455 (FGFR4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P22455 / FGFR4_HUMAN
Protein Name Fibroblast growth factor receptor 4 precursor
Gene Name Name: FGFR4
Synonyms:JTK2,TKF;
Organism Homo sapiens (Human)

PRO ID PR:P22455
DAG View
PRO Name fibroblast growth factor receptor 4 (human)
Definition A fibroblast growth factor receptor 4 that is encoded in the genome of human.
Short Label hFGFR4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P22455 (FGFR4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T167 Phosphorylation PhosphoSitePlus
N177 N-Glycosylation GlyGen 29391424
S232 Phosphorylation PhosphoSitePlus
N258 N-Glycosylation GlyGen 23090970, 24190977
T260 O-Glycosylation GlyGen 30459171
N290 N-Glycosylation GlyGen 29391424
N311 N-Glycosylation GlyGen 29391424
T368 Phosphorylation PhosphoSitePlus
Y390 Phosphorylation PhosphoSitePlus   UniProt 26675719
K408 Ubiquitination PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
N508 N-Glycosylation GlyGen 29391424
S519 Phosphorylation PhosphoSitePlus
S573 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K627 Ubiquitination PhosphoSitePlus
Y642 Phosphorylation neXtProt   PRO   PhosphoSitePlus   Signor   UniProt 7518429, 18480409, 18670643
Y642 Phosphorylation P22455 (FGFR4) neXtProt   Signor   UniProt 7518429, 18480409, 18670643
Y643 Phosphorylation neXtProt   PRO   PhosphoSitePlus   Signor   UniProt 7518429, 18480409, 18670643
Y643 Phosphorylation P22455 (FGFR4) neXtProt   Signor   UniProt 7518429, 18480409, 18670643
K644 Ubiquitination PhosphoSitePlus
Y719 Phosphorylation PRO
Y754 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   UniProt 7518429, 18480409, 18670643, ...8576110
Y754 Phosphorylation P22455 (FGFR4) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 7518429, 18480409, 18670643, ...8576110
Y764 Phosphorylation PRO
Site PTM Type PTM Enzyme Score Source PMID
S573 Phosphorylation HPRD 18691976
Y754 Phosphorylation HPRD 10918587, 8576110
Y754 Phosphorylation P22455 (FGFR4) HPRD 10918587, 8576110
Site PTM Type PTM Enzyme Score Source PMID
S533 Phosphorylation HPRD 18691976
Y714 Phosphorylation HPRD 10918587, 8576110
Y714 Phosphorylation P22455 (FGFR4) HPRD 10918587, 8576110


P22455 (FGFR4) as PTM Enzyme



Substrate Site Score Source PMID
P22455 (FGFR4) Y642 neXtProt   Signor   UniProt 7518429, 18480409, 18670643
P22455 (FGFR4) Y643 neXtProt   Signor   UniProt 7518429, 18480409, 18670643
P22455-2 (FGFR4) Y714 HPRD 10918587, 8576110
P22455 (FGFR4) Y754 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 7518429, 18480409, 18670643, ...10918587, 8576110
P40763-2 (STAT3) Y704 HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095
P40763-1 (STAT3) Y705 HPRD   Signor 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095, 16497976
P42224-1 (STAT1) Y701 HPRD   Signor 10918587, 7657660, 15322115, ...7543024, 11839738, 12817007, 7690989, 11294897, 12637327


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047415 (hFGFR4/SigPep-/Phos:1) pY642,pY643,pY719,pY754,pY764 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N177 S177 Biomuta DOID:4159 / skin cancer [ cosmic ]
N177 H177 Biomuta DOID:4159 / skin cancer [ cosmic ]
S232 I232 Biomuta DOID:1324 / lung cancer [ cosmic ]
N311 S311 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y390 H390 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S419 F419 Biomuta DOID:4159 / skin cancer [ cosmic ]
S439 F439 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
S440 P440 Biomuta DOID:1612 / breast cancer [ cosmic ]
S441 R441 Biomuta DOID:3565 / meningioma [ cosmic ]
K471 N471 Biomuta DOID:363 / uterine cancer [ icgc ]
N508 S508 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y714 C714 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y719 C719 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y754 C754 Biomuta DOID:9256 / colorectal cancer [ cosmic ]