iPTMnet Report for P22415 (USF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P22415 / USF1_HUMAN
Protein Name Upstream stimulatory factor 1
Gene Name Name: USF1
Synonyms:BHLHB11,USF;
Organism Homo sapiens (Human)

PRO ID PR:P22415
DAG View
PRO Name upstream stimulatory factor 1 (human)
Definition An upstream stimulatory factor 1 that is encoded in the genome of human.
Short Label hUSF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P22415 (USF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T100 Phosphorylation RLIMS-P 25194820
T153 Phosphorylation P49840 (GSK3A) , Q16539 (MAPK14) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 19389701, 21873430, 11532965, ...29871931
S186 Phosphorylation P49840 (GSK3A) PhosphoSitePlus   RLIMS-P 21873430
S189 Phosphorylation PhosphoSitePlus
K199 Acetylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K235 Acetylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
C248 Methylation IEDB 31844290
S262 Phosphorylation P78527 (PRKDC) neXtProt   PhosphoSitePlus 23219531, 19303849
K286 Ubiquitination PhosphoSitePlus
K288 Sumoylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K306 Sumoylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S223 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S164 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T100 S100 Biomuta DOID:1324 / lung cancer [ cosmic ]
S186 Y186 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S223 C223 Biomuta DOID:1324 / lung cancer [ cosmic ]
K286 R286 Biomuta DOID:1319 / brain cancer [ cosmic ]
K288 R288 Biomuta DOID:1319 / brain cancer [ cosmic ]
K288 * Biomuta DOID:1319 / brain cancer [ cosmic ]
K288 N288 Biomuta DOID:1319 / brain cancer [ cosmic ]