iPTMnet Report for P22392 (NME2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P22392 / NDKB_HUMAN
Protein Name Nucleoside diphosphate kinase B
Gene Name Name: NME2
Synonyms:NM23B;
Organism Homo sapiens (Human)

PRO ID PR:P22392
DAG View
PRO Name nucleoside diphosphate kinase B (human)
Definition A nucleoside diphosphate kinase B that is encoded in the genome of human.
Short Label hNME2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P22392 (NME2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R6 Methylation PhosphoSitePlus
K12 Acetylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
R18 Methylation PhosphoSitePlus
K26 Acetylation PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
K31 Acetylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K39 Acetylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
R42 Methylation PhosphoSitePlus
S44 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 8245015
S44 Phosphorylation P22392 (NME2) Signor 8245015
K49 Acetylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
Y52 Phosphorylation PhosphoSitePlus
K56 Acetylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
R58 Methylation PhosphoSitePlus
K66 Acetylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K85 Acetylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
R88 Methylation PhosphoSitePlus
T94 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18234856
T94 Phosphorylation P06493 (CDK1) PhosphoSitePlus 18234856
S99 Phosphorylation PhosphoSitePlus
K100 Acetylation PhosphoSitePlus
K100 Methylation PhosphoSitePlus
K100 Sumoylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
T103 Phosphorylation PhosphoSitePlus
R114 Methylation PhosphoSitePlus
H118 Phosphorylation PhosphoSitePlus 17157250
H118 Phosphorylation P22392 (NME2) PhosphoSitePlus 17157250
S120 Phosphorylation PhosphoSitePlus   RLIMS-P 7658474
S122 O-Glycosylation GlyGen 33214551, 35138101, 30397120, ...34725712, 34229054, 34019948, 32119511, 36240223, 33465208
S122 Phosphorylation PhosphoSitePlus
K124 Acetylation PhosphoSitePlus
K124 Sumoylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
K128 Acetylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
K135 Acetylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
Y142 Phosphorylation PhosphoSitePlus
K143 Acetylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
Y151 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S44 Phosphorylation HPRD 8245015
S44 Phosphorylation P22392 (NME2) HPRD 8245015
H118 Phosphorylation HPRD 1851158
H118 Phosphorylation P22392 (NME2) HPRD 1851158
S120 Phosphorylation HPRD 19651622, 20068231
S122 Phosphorylation HPRD 19651622, 20068231
Site PTM Type PTM Enzyme Score Source PMID
K12 Ubiquitination PhosphoSitePlus
K26 Acetylation PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K39 Acetylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
K49 Acetylation PhosphoSitePlus
K49 Sumoylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
Y52 Phosphorylation PhosphoSitePlus
K56 Sumoylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K66 Acetylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K85 Acetylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
T94 Phosphorylation PhosphoSitePlus
S99 Phosphorylation PhosphoSitePlus
K100 Acetylation PhosphoSitePlus
K100 Methylation PhosphoSitePlus
K100 Sumoylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
T103 Phosphorylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K141 Acetylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K154 Acetylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
S159 Phosphorylation HPRD   PhosphoSitePlus 8245015
S159 Phosphorylation P22392 (NME2) HPRD 8245015
K164 Ubiquitination PhosphoSitePlus
Y167 Phosphorylation PhosphoSitePlus
K171 Acetylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
K181 Acetylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
K200 Acetylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
T209 Phosphorylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
K215 Acetylation PhosphoSitePlus
K215 Methylation PhosphoSitePlus
K215 Sumoylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
T218 Phosphorylation PhosphoSitePlus
H233 Phosphorylation HPRD 1851158
H233 Phosphorylation P22392 (NME2) HPRD 1851158
S235 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
S237 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
K239 Acetylation PhosphoSitePlus
K239 Sumoylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K243 Acetylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K250 Acetylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
Y266 Phosphorylation PhosphoSitePlus


P22392 (NME2) as PTM Enzyme



Substrate Site Score Source PMID
O15554 (KCNN4) H358 PhosphoSitePlus   Signor 17157250, 18796614
P22392-1 (NME2) S44 HPRD   Signor 8245015
P22392 (NME2) H118 HPRD   PhosphoSitePlus 17157250, 1851158
P22392-2 (NME2) S159 HPRD 8245015
P22392-2 (NME2) H233 HPRD 1851158


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R6 H6 Biomuta DOID:4159 / skin cancer [ cosmic ]
R6 L6 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K39 Q39 Biomuta DOID:4362 / cervical cancer [ icgc ]
S44 C44 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
K49 R49 Biomuta DOID:2531 / hematologic cancer [ icgc ]
R58 P58 Biomuta DOID:4159 / skin cancer [ cosmic ]
R58 Q58 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R88 Q88 Biomuta [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]