iPTMnet Report for P22314 (UBA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P22314 / UBA1_HUMAN
Protein Name Ubiquitin-like modifier-activating enzyme 1
Gene Name Name: UBA1
Synonyms:A1S9T,UBE1;
Organism Homo sapiens (Human)

PRO ID PR:P22314
DAG View
PRO Name ubiquitin-like modifier-activating enzyme 1 (human)
Definition A ubiquitin-like modifier-activating enzyme 1 that is encoded in the genome of human.
Short Label hUBA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P22314 (UBA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
S2 O-Glycosylation GlyGen 33465208
S3 O-Glycosylation GlyGen 18434435, 16408927, 33214551, ...35138101, 23301498, 30397120, 34725712, 26853435, 29351928, 34019948, 35083852, 35008409, 22967762, 32119511, 33465208
S3 Phosphorylation PhosphoSitePlus
S4 O-Glycosylation GlyGen 33465208
S4 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 9099746, 7673335
S4 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   Signor 9099746, 7673335
S7 O-Glycosylation GlyGen 18434435, 16408927, 33214551, ...35138101, 23301498, 30397120, 34725712, 26853435, 29351928, 34019948, 35083852, 35008409, 22967762, 32119511, 33465208
S7 Phosphorylation PhosphoSitePlus
S13 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 8663123
S21 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S24 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S28 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
S46 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...18669648, 19690332, 20068231
Y55 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
S56 Phosphorylation PhosphoSitePlus
Y60 Phosphorylation PhosphoSitePlus
K68 Acetylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S74 O-Glycosylation GlyGen 18434435, 16408927, 33214551, ...35138101, 23301498, 30397120, 34725712, 26853435, 29351928, 34019948, 35083852, 35008409, 22967762, 32119511, 33465208
S74 Phosphorylation PhosphoSitePlus
S78 O-Glycosylation GlyGen 18434435, 16408927, 33214551, ...35138101, 23301498, 30397120, 34725712, 26853435, 29351928, 34019948, 35083852, 35008409, 22967762, 32119511, 33465208
R81 Methylation PhosphoSitePlus
K89 Acetylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
R119 Methylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
C179 Methylation IEDB 31844290
K185 Acetylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
T191 Phosphorylation PhosphoSitePlus
C234 S-Nitrosylation dbSNO 20140087, 22178444
Y273 Phosphorylation PhosphoSitePlus
T274 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
Y286 Phosphorylation PhosphoSitePlus
R288 Methylation PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
K304 Methylation PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
T318 Phosphorylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
R368 Methylation PhosphoSitePlus
R384 Methylation PhosphoSitePlus
K385 Acetylation PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
Y388 Phosphorylation PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
K465 Acetylation PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
K470 Acetylation PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
C481 S-Nitrosylation dbSNO 26338901
K526 Ubiquitination PhosphoSitePlus
K528 Sumoylation PhosphoSitePlus
K528 Ubiquitination PhosphoSitePlus
R537 Methylation PhosphoSitePlus
R544 Methylation PhosphoSitePlus
R551 Methylation PhosphoSitePlus
R558 Methylation PhosphoSitePlus
Y560 Phosphorylation PhosphoSitePlus
C588 Methylation IEDB 31844290
C588 S-Nitrosylation dbSNO 26338901
Y590 Phosphorylation PhosphoSitePlus
K593 Acetylation PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
T600 Phosphorylation PhosphoSitePlus
T603 Phosphorylation PhosphoSitePlus
K604 Acetylation PhosphoSitePlus
K604 Sumoylation PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
T615 Phosphorylation PhosphoSitePlus
S619 O-Glycosylation GlyGen 18434435, 16408927, 33214551, ...35138101, 23301498, 30397120, 34725712, 26853435, 29351928, 34019948, 35083852, 35008409, 22967762, 32119511, 33465208
K627 Acetylation PhosphoSitePlus
K627 Ubiquitination PhosphoSitePlus
S628 Phosphorylation PhosphoSitePlus
C632 S-Nitrosylation dbSNO 19483679, 26338901
K635 Sumoylation PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
K657 Ubiquitination PhosphoSitePlus
K671 Acetylation PhosphoSitePlus   UniProt 19608861
K671 Ubiquitination PhosphoSitePlus
R678 Methylation PhosphoSitePlus
T682 Phosphorylation PhosphoSitePlus
K746 Ubiquitination PhosphoSitePlus
S781 Phosphorylation PhosphoSitePlus
T789 Phosphorylation PhosphoSitePlus
S793 Phosphorylation PhosphoSitePlus
T800 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K802 Ubiquitination PhosphoSitePlus
S803 Phosphorylation PhosphoSitePlus
K806 Ubiquitination PhosphoSitePlus
S810 Phosphorylation PhosphoSitePlus   UniProt 19690332, 20068231
S816 Phosphorylation PhosphoSitePlus
S820 Phosphorylation PhosphoSitePlus   UniProt 24275569
S824 Phosphorylation PhosphoSitePlus
K830 Ubiquitination PhosphoSitePlus
T832 Phosphorylation phospho.ELM 18669648
S835 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 7724583, 18669648, 7673335, ...23186163
S835 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   Signor 7724583, 7673335
K838 Acetylation PhosphoSitePlus
K838 Ubiquitination PhosphoSitePlus
K843 Ubiquitination PhosphoSitePlus
S855 Phosphorylation PhosphoSitePlus
S866 Phosphorylation PhosphoSitePlus
Y873 Phosphorylation PhosphoSitePlus
R880 Methylation PhosphoSitePlus
K884 Acetylation PhosphoSitePlus
K889 Ubiquitination PhosphoSitePlus
R917 Methylation PhosphoSitePlus
K923 Ubiquitination PhosphoSitePlus
R957 Methylation PhosphoSitePlus
Y978 Phosphorylation PhosphoSitePlus
K980 Acetylation PhosphoSitePlus   UniProt 19608861
K980 Ubiquitination PhosphoSitePlus
T1016 Phosphorylation IEDB 35494241
K1024 Acetylation PhosphoSitePlus
C1039 S-Nitrosylation dbSNO 26338901
C1040 S-Nitrosylation dbSNO 26338901
S1044 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation HPRD 7673335, 20068231
S4 Phosphorylation P06493 (CDK1) HPRD 7673335, 20068231
S13 Phosphorylation HPRD 18669648, 20068231
S21 Phosphorylation HPRD 18669648, 20068231
S24 Phosphorylation HPRD 18669648
S35 Phosphorylation HPRD 20068231
T38 Phosphorylation HPRD 17081983, 20068231
S46 Phosphorylation HPRD 16964243, 15302935, 18452278, ...19651622, 18669648, 19415658, 20068231, 18212344
Y55 Phosphorylation HPRD 15592455
S305 Phosphorylation HPRD 20068231
S309 Phosphorylation HPRD 20068231
T318 Phosphorylation HPRD 20068231
S529 Phosphorylation HPRD 20068231
T800 Phosphorylation HPRD 18669648, 20068231
S810 Phosphorylation HPRD 20068231
S816 Phosphorylation HPRD 20068231
S820 Phosphorylation HPRD 20068231
T832 Phosphorylation HPRD 18669648
S835 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231, 7724583
S835 Phosphorylation P06493 (CDK1) HPRD 19413330, 19651622, 18669648, ...20068231, 7724583


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 L4 Biomuta DOID:4159 / skin cancer [ cosmic ]
S21 Y21 Biomuta DOID:363 / uterine cancer [ icgc ]
S35 L35 Biomuta DOID:363 / uterine cancer [ icgc ]
Y60 S60 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K68 T68 Biomuta DOID:363 / uterine cancer [ icgc ]
R81 W81 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
R119 Q119 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R119 W119 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T191 M191 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S293 N293 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K296 R296 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
R368 Q368 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K416 E416 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R551 H551 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R558 C558 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R558 H558 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
Y560 H560 Biomuta DOID:4159 / skin cancer [ cosmic ]
C588 R588 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K593 N593 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T603 I603 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T615 K615 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S628 F628 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R678 W678 Biomuta DOID:363 / uterine cancer [ icgc ]
S793 F793 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T800 P800 Biomuta DOID:1612 / breast cancer [ cosmic ]
S816 N816 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K838 N838 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R880 W880 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R880 Q880 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K884 M884 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K923 E923 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]