Protein Information

Cytoscape View


UniProt AC / UniProt ID P22234 / PUR6_HUMAN
Protein Name Multifunctional protein ADE2
Gene Name Name: PAICS
Synonyms:ADE2,AIRC,PAIS;
Organism Homo sapiens (Human)

PRO ID PR:P22234
DAG View
PRO Name multifunctional protein ADE2 (human)
Definition A multifunctional protein ADE2 that is encoded in the genome of human.
Short Label hPAICS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P22234 (PAICS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895
T3 Phosphorylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
K12 Acetylation PhosphoSitePlus
Y14 Phosphorylation PhosphoSitePlus
T18 Phosphorylation PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
Y22 Phosphorylation PhosphoSitePlus
S27 Phosphorylation P24941 (CDK2) , P06493 (CDK1) phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 23186163, ...16964243, 18691976, 18847512, 18234856, 18669648, 19690332, 20068231, 17924679
K30 Acetylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
T40 Phosphorylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
K53 Acetylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
C63 S-Nitrosylation dbSNO 26338901
K74 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
T105 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
K110 Acetylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
Y122 Phosphorylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
R222 Methylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
Y231 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
T238 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163
K246 Acetylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K247 Acetylation PhosphoSitePlus   UniProt 19608861
K247 Ubiquitination PhosphoSitePlus
K261 Acetylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S276 Phosphorylation PhosphoSitePlus
K283 Acetylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
K304 Acetylation PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
T309 Phosphorylation PhosphoSitePlus
R311 Methylation PhosphoSitePlus
K313 Sumoylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
Y345 Phosphorylation PhosphoSitePlus
T354 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
S400 Phosphorylation PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
T409 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation HPRD 19651622
Y22 Phosphorylation HPRD 17322306
S27 Phosphorylation HPRD 19413330, 18691976, 16964243, ...20230923, 18767875, 20058876, 19664995, 18452278, 17322306, 19664994, 18669648, 19651622, 19415658, 20068231, 17924679
S35 Phosphorylation HPRD 20230923
S107 Phosphorylation HPRD 18669648, 20068231
T238 Phosphorylation HPRD 19413330, 18691976, 18669648, ...20068231
T309 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation HPRD 19651622
Y22 Phosphorylation HPRD 17322306
S27 Phosphorylation HPRD 19413330, 18691976, 16964243, ...20230923, 18767875, 20058876, 19664995, 18452278, 17322306, 19664994, 18669648, 19651622, 19415658, 20068231, 17924679
S35 Phosphorylation HPRD 20230923
S114 Phosphorylation HPRD 18669648, 20068231
T245 Phosphorylation HPRD 19413330, 18691976, 18669648, ...20068231
T316 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y14 C14 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S35 F35 Biomuta DOID:1612 / breast cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
K53 R53 Biomuta DOID:1324 / lung cancer [ cosmic ]
K120 R120 Biomuta DOID:363 / uterine cancer [ tcga ]
R222 Q222 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:363 / uterine cancer [ tcga ] DOID:0070003 / blastoma [ cosmic ]
R222 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K283 T283 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]