iPTMnet Report for P22102 (GART)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P22102 / PUR2_HUMAN
Protein Name Trifunctional purine biosynthetic protein adenosine-3
Gene Name Name: GART
Synonyms:PGFT,PRGS;
Organism Homo sapiens (Human)

PRO ID PR:P22102
DAG View
PRO Name trifunctional purine biosynthetic protein adenosine-3 (human)
Definition A trifunctional purine biosynthetic protein adenosine-3 that is encoded in the genome of human.
Short Label hGART
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P22102 (GART) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
S10 Phosphorylation PhosphoSitePlus   UniProt 23186163
R13 Methylation PhosphoSitePlus
K20 Acetylation PhosphoSitePlus
K20 Methylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
K28 Acetylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
C41 S-Nitrosylation dbSNO 22178444
S42 Phosphorylation PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
C93 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
K107 Acetylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
R116 Methylation PhosphoSitePlus
T121 Phosphorylation PhosphoSitePlus
K125 Methylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K219 Acetylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
T230 Phosphorylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
Y274 Phosphorylation IEDB 35494241
K281 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
C298 Methylation IEDB 31844290
C298 S-Nitrosylation dbSNO 19483679
Y348 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T349 Phosphorylation PhosphoSitePlus
K350 Acetylation PhosphoSitePlus   UniProt 19608861
K350 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
Y417 Phosphorylation PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
R433 Methylation PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus   UniProt 23186163
K452 Ubiquitination PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
K480 Methylation PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
T498 Phosphorylation PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
K598 Ubiquitination PhosphoSitePlus
S625 Phosphorylation PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
K676 Ubiquitination PhosphoSitePlus
T682 Phosphorylation PhosphoSitePlus   UniProt 23186163
K697 Ubiquitination PhosphoSitePlus
S714 Phosphorylation PhosphoSitePlus
S723 Phosphorylation PhosphoSitePlus
K743 Ubiquitination PhosphoSitePlus
K757 Ubiquitination PhosphoSitePlus
K779 Ubiquitination PhosphoSitePlus
S784 Phosphorylation PhosphoSitePlus
S796 Phosphorylation PhosphoSitePlus   UniProt 23186163
T798 Phosphorylation PhosphoSitePlus
S802 Phosphorylation PhosphoSitePlus   UniProt 23186163
K844 Acetylation PhosphoSitePlus
K852 Acetylation PhosphoSitePlus
K852 Ubiquitination PhosphoSitePlus
R855 Methylation PhosphoSitePlus
T860 Phosphorylation PhosphoSitePlus
K866 Acetylation IEDB   PhosphoSitePlus 34357683
K866 Ubiquitination PhosphoSitePlus
K910 Ubiquitination PhosphoSitePlus
S973 Phosphorylation PhosphoSitePlus
K977 Acetylation PhosphoSitePlus
K977 Ubiquitination PhosphoSitePlus
K982 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T121 Phosphorylation HPRD 20068231
Y348 Phosphorylation HPRD 15592455, 18083107
T817 Phosphorylation HPRD 20068231
S819 Phosphorylation HPRD 20068231
S827 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T121 Phosphorylation HPRD 20068231
Y348 Phosphorylation HPRD 15592455, 18083107


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C93 F93 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
C93 S93 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K111 E111 Biomuta DOID:1324 / lung cancer [ cosmic ]
K249 R249 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K251 R251 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y274 H274 Biomuta DOID:363 / uterine cancer [ icgc ]
S398 L398 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K404 N404 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K438 E438 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K453 E453 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S491 Y491 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S491 F491 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K501 N501 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K501 T501 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S625 R625 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S802 F802 Biomuta DOID:4159 / skin cancer [ cosmic ]
S819 L819 Biomuta DOID:363 / uterine cancer [ cosmic ]
K977 N977 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]