Protein Information

Cytoscape View

UniProt AC / UniProt ID P22061 / PIMT_HUMAN
Protein Name Protein-L-isoaspartate(D-aspartate) O-methyltransferase
Gene Name Name: PCMT1
Organism Homo sapiens (Human)

PRO ID PR:P22061
DAG View
PRO Name protein-L-isoaspartate(D-aspartate) O-methyltransferase (human)
Definition A protein-L-isoaspartate(D-aspartate) O-methyltransferase that is encoded in the genome of human.
Short Label hPCMT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P22061 (PCMT1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 2684970
K4 Ubiquitination PhosphoSitePlus
R37 Methylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
S119 O-Glycosylation GlyGen 28510447, 21740066, 29351928
R124 Methylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
S202 O-Glycosylation GlyGen 28510447, 21740066, 29351928
K206 Ubiquitination PhosphoSitePlus
Y213 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K125 N125 Biomuta DOID:1909 / melanoma [ cosmic ]
K125 E125 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S202 I202 Biomuta DOID:3571 / liver cancer [ icgc ]