Protein Information

Cytoscape View


UniProt AC / UniProt ID P22059 / OSBP1_HUMAN
Protein Name Oxysterol-binding protein 1
Gene Name Name: OSBP
Synonyms:OSBP1;
Organism Homo sapiens (Human)

PRO ID PR:P22059
DAG View
PRO Name oxysterol-binding protein 1 (human)
Definition An oxysterol-binding protein 1 that is encoded in the genome of human.
Short Label hOSBP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P22059 (OSBP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 25944712
T4 Phosphorylation HPRD 20068231
R7 Methylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K103 Acetylation PhosphoSitePlus
Y105 Phosphorylation PhosphoSitePlus
Y119 Phosphorylation PhosphoSitePlus
T129 Phosphorylation PhosphoSitePlus
T174 Phosphorylation PhosphoSitePlus
S190 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17322306, 18088087, ...17081983, 18767875, 20058876, 18452278, 19651622, 15302935, 18669648, 19690332, 24275569, 20166139, 23186163, 18318008, 19415658, 20068231
S193 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 15302935, 18088087, ...17081983, 18767875, 20058876, 21406692, 18452278, 19651622, 17322306, 18669648, 19690332, 24275569, 20166139, 23186163, 18318008, 19415658, 20068231
S198 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 20166139, 18669648
S200 Phosphorylation PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus
T210 Phosphorylation PhosphoSitePlus
T213 Phosphorylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
T233 Phosphorylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus   UniProt 23186163
S240 Phosphorylation Q15139 (PRKD1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 23186163, 20058876, 19664994, ...18669648, 20166139, 21285358, 20444975
K246 Ubiquitination PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus   RLIMS-P 20444975
S287 Phosphorylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
Y296 Phosphorylation PhosphoSitePlus
R323 Methylation PhosphoSitePlus
T332 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus   UniProt 23186163
K340 Ubiquitination PhosphoSitePlus
S345 Phosphorylation HPRD   phospho.ELM 18669648, 17081983, 20068231
S351 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 18088087, ...17081983, 20230923, 19664994, 18452278, 19651622, 18669648, 24275569, 20166139, 23186163, 18318008, 19690332, 20068231
T377 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 17081983, ...18669648, 24275569, 20166139, 20068231
S379 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18088087, 18767875, ...17322306, 18669648, 20166139, 23186163, 20068231
S382 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18088087, 17081983, ...18669648, 24275569, 20166139, 23186163, 19690332, 20068231
S385 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 17081983, ...18669648, 24275569, 20166139, 18088087, 20068231
S386 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18088087, 17081983, ...18669648, 24275569, 20166139, 23186163, 20068231
S389 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18088087, 17081983, ...23186163
K395 Ubiquitination PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
Y456 Phosphorylation PhosphoSitePlus
R462 Methylation PhosphoSitePlus
S469 Phosphorylation PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
K544 Ubiquitination PhosphoSitePlus
Y553 Phosphorylation PhosphoSitePlus
Y573 Phosphorylation PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
T628 Phosphorylation PhosphoSitePlus
S635 Phosphorylation PhosphoSitePlus
T645 Phosphorylation PhosphoSitePlus
T758 Phosphorylation PhosphoSitePlus
T762 Phosphorylation PhosphoSitePlus
Y764 Phosphorylation PhosphoSitePlus
Y767 Phosphorylation PhosphoSitePlus
K768 Ubiquitination PhosphoSitePlus
T780 Phosphorylation PhosphoSitePlus
Y787 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T174 M174 Biomuta DOID:1324 / lung cancer [ tcga ]
S193 * Biomuta DOID:3571 / liver cancer [ icgc ]
T210 A210 Biomuta DOID:1324 / lung cancer [ tcga ]
K246 T246 Biomuta DOID:0070003 / blastoma [ cosmic ]
S345 F345 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
T377 I377 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T628 M628 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T645 A645 Biomuta DOID:1319 / brain cancer [ icgc ]