iPTMnet Report for P22033 (MMUT)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P22033 / MUTA_HUMAN
Protein Name Methylmalonyl-CoA mutase, mitochondrial precursor
Gene Name Name: MMUT
Synonyms:MUT;
Organism Homo sapiens (Human)

PRO ID PR:P22033
DAG View
PRO Name methylmalonyl-CoA mutase, mitochondrial (human)
Definition A methylmalonyl-CoA mutase, mitochondrial that is encoded in the genome of human.
Short Label hMMUT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P22033 (MMUT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S68 Phosphorylation PhosphoSitePlus
K89 Acetylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
T216 Phosphorylation PhosphoSitePlus
Y231 Phosphorylation HPRD 20068231
S238 Phosphorylation PhosphoSitePlus
Y248 Phosphorylation PhosphoSitePlus
T249 Phosphorylation HPRD 20068231
Y287 Phosphorylation PhosphoSitePlus
K335 Acetylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
Y364 Phosphorylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus   UniProt 24275569
S483 Phosphorylation PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S68 F68 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K89 T89 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y248 H248 Biomuta DOID:363 / uterine cancer [ icgc ]
Y364 C364 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y364 S364 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S481 C481 Biomuta DOID:1324 / lung cancer [ cosmic ]