iPTMnet Report for P22001 (KCNA3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P22001 / KCNA3_HUMAN
Protein Name Potassium voltage-gated channel subfamily A member 3
Gene Name Name: KCNA3
Synonyms:HGK5;
Organism Homo sapiens (Human)

PRO ID PR:P22001
DAG View
PRO Name potassium voltage-gated channel subfamily A member 3 (human)
Definition A voltage-gated potassium channel subunit KCNA3 that is encoded in the genome of human.
Short Label hKCNA3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P22001 (KCNA3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
Y161 Phosphorylation Q16620 (NTRK2) PhosphoSitePlus   Signor 19166614
Y162 Phosphorylation Q16620 (NTRK2) PhosphoSitePlus   Signor 19166614
Y163 Phosphorylation Q16620 (NTRK2) PhosphoSitePlus   Signor 19166614
Y187 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 11812778
K196 Ubiquitination PhosphoSitePlus
N279 N-Glycosylation GlyGen 24190977
S378 Phosphorylation PhosphoSitePlus
Y447 Phosphorylation P12931 (SRC) phospho.ELM 11812778
Y499 Phosphorylation P12931 (SRC) , Q16620 (NTRK2) PhosphoSitePlus   Signor 19166614, 11812778
S504 Phosphorylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
T523 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
K526 Ubiquitination PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus
Y529 Phosphorylation PhosphoSitePlus
S564 Phosphorylation PhosphoSitePlus
K569 Ubiquitination PhosphoSitePlus
K570 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K120 N120 Biomuta DOID:184 / bone cancer [ cosmic ]
S378 P378 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S378 L378 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
Y447 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y447 C447 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
Y499 H499 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S511 L511 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S520 I520 Biomuta DOID:3571 / liver cancer [ cosmic ]
S527 L527 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:2394 / ovarian cancer [ cosmic ]
K570 N570 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]