iPTMnet Report for P21980 (TGM2)
Protein Information
| UniProt AC / UniProt ID | P21980 / TGM2_HUMAN |
| Protein Name | Protein-glutamine gamma-glutamyltransferase 2 |
| Gene Name | Name: TGM2 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P21980 |
| PRO Name | protein-glutamine gamma-glutamyltransferase 2 (human) |
| Definition | A protein-glutamine gamma-glutamyltransferase 2 that is encoded in the genome of human. |
| Short Label | hTGM2 |
| Category | organism-gene |
DAG ViewP21980 (TGM2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| A2 | Acetylation | score1 | UniProt | 22814378 | ||
| C10 | S-Nitrosylation | score2 | dbSNO | 22178444, 11305905 | ||
| C27 | S-Nitrosylation | score2 | dbSNO | 22178444, 11305905 | ||
| S56 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S60 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| S68 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C98 | S-Nitrosylation | score2 | dbSNO | 22178444, 11305905 | ||
| Y115 | Phosphorylation | score1 | IEDB | 32387766 | ||
| S129 | Phosphorylation | score0 | RLIMS-P | 22389828 | ||
| C143 | S-Nitrosylation | score2 | dbSNO | 22178444, 11305905 | ||
| Y159 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T162 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K202 | Acetylation | score1 | PhosphoSitePlus | |||
| K205 | Acetylation | score1 | PhosphoSitePlus | |||
| S212 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S215 | Phosphorylation | P17612 (PRKACA) | score2 | PhosphoSitePlus | 16870138 | |
| S216 | Phosphorylation | P17612 (PRKACA) | score4 | PhosphoSitePlus RLIMS-P | 22759359, 16870138 | |
| Y219 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18083107 | ||
| C230 | S-Nitrosylation | score2 | dbSNO | 22178444, 11305905 | ||
| Y245 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S250 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C269 | S-Nitrosylation | score2 | dbSNO | 22178444, 11305905 | ||
| C277 | S-Nitrosylation | score2 | dbSNO | 22178444, 11305905 | ||
| C285 | S-Nitrosylation | score2 | dbSNO | 22178444, 11305905 | ||
| Y315 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C336 | S-Nitrosylation | score2 | dbSNO | 22178444, 11305905 | ||
| T368 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y369 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 15592455, 18083107 | ||
| C370 | S-Nitrosylation | score2 | dbSNO | 22178444, 2212679, 22126794, ... | ||
| C371 | S-Nitrosylation | score2 | dbSNO | 22178444, 2212679, 22126794, ... | ||
| S415 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S419 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S427 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K464 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C524 | S-Nitrosylation | score2 | dbSNO | 22178444, 2212679, 22126794, ... | ||
| S538 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S541 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C545 | S-Nitrosylation | score2 | dbSNO | 22178444, 11305905 | ||
| C554 | S-Nitrosylation | score0 | dbSNO | 2212679, 22126794 | ||
| Y575 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y583 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K590 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S608 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C620 | S-Nitrosylation | score2 | dbSNO | 22178444, 11305905 | ||
| K649 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K672 | Acetylation | score1 | PhosphoSitePlus |
P21980 (TGM2) as PTM Enzyme
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | P04637 (TP53) | S15 | P21980 (TGM2) | unknown | eFIP | 27031960 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| A2 | T2 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S60 | G60 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| C98 | Y98 | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
| Y115 | C115 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| Y245 | N245 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S250 | I250 | Biomuta | DOID:1319 / brain cancer [ icgc ] | |
| C269 | S269 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| Y315 | N315 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| C545 | W545 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S608 | F608 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S608 | Y608 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc, tcga ] | |
| C620 | * | Biomuta | DOID:2394 / ovarian cancer [ cosmic ] | |
| C620 | Y620 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] |
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