Protein Information

Cytoscape View


UniProt AC / UniProt ID P21964 / COMT_HUMAN
Protein Name Catechol O-methyltransferase
Gene Name Name: COMT
Organism Homo sapiens (Human)

PRO ID PR:P21964
DAG View
PRO Name catechol O-methyltransferase (human)
Definition A catechol O-methyltransferase that is encoded in the genome of human.
Short Label hCOMT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P21964 (COMT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T81 Phosphorylation PhosphoSitePlus
Y82 Phosphorylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K95 Acetylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
C145 S-Nitrosylation dbSNO 26338901
K159 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K179 Acetylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
Y180 Phosphorylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
Y244 Phosphorylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
Y262 Phosphorylation PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y180 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
Y130 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y82 C82 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K95 N95 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]