iPTMnet Report for P21912 (SDHB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P21912 / SDHB_HUMAN
Protein Name Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor
Gene Name Name: SDHB
Synonyms:SDH,SDH1;
Organism Homo sapiens (Human)

PRO ID PR:P21912
DAG View
PRO Name succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (human)
Definition A succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial that is encoded in the genome of human.
Short Label hSDHB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P21912 (SDHB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T35 O-Glycosylation GlyGen 33465208, 34229054
K41 Acetylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
C93 S-Nitrosylation dbSNO 26338901
C98 S-Nitrosylation dbSNO 26338901
C101 S-Nitrosylation dbSNO 26338901
C113 S-Nitrosylation dbSNO 26338901
T119 Phosphorylation HPRD   PhosphoSitePlus 20068231
K123 Ubiquitination PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
Y216 Phosphorylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
K233 Acetylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C93 Y93 Biomuta DOID:263 / kidney cancer [ cosmic ]
C98 S98 Biomuta DOID:1324 / lung cancer [ cosmic ]
C101 * Biomuta DOID:4159 / skin cancer [ cosmic ]