iPTMnet Report for P21817 (RYR1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P21817 / RYR1_HUMAN
Protein Name Ryanodine receptor 1
Gene Name Name: RYR1
Synonyms:RYDR;
Organism Homo sapiens (Human)

PRO ID PR:P21817
DAG View
PRO Name ryanodine receptor 1 (human)
Definition A ryanodine receptor 1 that is encoded in the genome of human.
Short Label hRYR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P21817 (RYR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C35 S-Nitrosylation dbSNO 17071618
S157 Phosphorylation PhosphoSitePlus
Y245 Phosphorylation PhosphoSitePlus
C252 S-Nitrosylation dbSNO 17071618
C314 S-Nitrosylation dbSNO 17071618
S421 Phosphorylation PhosphoSitePlus
S587 Phosphorylation IEDB 35494241
T675 Phosphorylation PhosphoSitePlus
T679 Phosphorylation PhosphoSitePlus
S781 Phosphorylation PhosphoSitePlus
C810 S-Nitrosylation dbSNO 17071618
C905 S-Nitrosylation dbSNO 17071618
Y1023 Phosphorylation PhosphoSitePlus
C1039 S-Nitrosylation dbSNO 17071618
C1302 S-Nitrosylation dbSNO 17071618
T1399 Phosphorylation PhosphoSitePlus
C1590 S-Nitrosylation dbSNO 17071618
S1728 Phosphorylation PhosphoSitePlus
S1731 Phosphorylation PhosphoSitePlus
Y1733 Phosphorylation PhosphoSitePlus
K1860 Acetylation PhosphoSitePlus
Y1965 Phosphorylation PhosphoSitePlus
K2069 Ubiquitination PhosphoSitePlus
S2085 Phosphorylation PhosphoSitePlus
R2118 Methylation PhosphoSitePlus
C2326 S-Nitrosylation dbSNO 17071618
C2363 S-Nitrosylation dbSNO 17071618
Y2426 Phosphorylation PhosphoSitePlus
S2459 Phosphorylation PhosphoSitePlus
T2543 Phosphorylation PhosphoSitePlus
S2594 Phosphorylation PhosphoSitePlus
T2596 Phosphorylation PhosphoSitePlus
Y2761 Phosphorylation PhosphoSitePlus
T2762 Phosphorylation PhosphoSitePlus
S2843 Phosphorylation PhosphoSitePlus   RLIMS-P 23173055, 14532276, 29953482, ...30635368, 12629052, 22913516
T2848 Phosphorylation PhosphoSitePlus
S2863 Phosphorylation PhosphoSitePlus
S2868 Phosphorylation PhosphoSitePlus
Y2935 Phosphorylation PhosphoSitePlus
K2953 Acetylation PhosphoSitePlus
S3027 Phosphorylation PhosphoSitePlus
S3032 Phosphorylation PhosphoSitePlus
T3079 Phosphorylation PhosphoSitePlus
Y3131 Phosphorylation PhosphoSitePlus
T3132 Phosphorylation PhosphoSitePlus
T3133 Phosphorylation PhosphoSitePlus
T3177 Phosphorylation PhosphoSitePlus
T3178 Phosphorylation PhosphoSitePlus
C3193 S-Nitrosylation dbSNO 17071618
S3489 Phosphorylation PhosphoSitePlus
C3635 S-Nitrosylation dbSNO 17071618, 12509428, 15688001, ...11562475
S3668 Phosphorylation PhosphoSitePlus
S3751 Phosphorylation PhosphoSitePlus
T3771 Phosphorylation PhosphoSitePlus
T3918 Phosphorylation PhosphoSitePlus
Y3921 Phosphorylation PhosphoSitePlus
T4081 Phosphorylation PhosphoSitePlus
S4212 Phosphorylation PhosphoSitePlus
K4229 Methylation PhosphoSitePlus
T4324 Phosphorylation PhosphoSitePlus
T4330 Phosphorylation PhosphoSitePlus
T4341 O-Glycosylation GlyGen 28411811, 35469018
T4341 Phosphorylation PhosphoSitePlus
K4551 Ubiquitination PhosphoSitePlus
T4823 Phosphorylation PhosphoSitePlus
T4826 Phosphorylation PhosphoSitePlus
S4829 Phosphorylation PhosphoSitePlus
T4832 Phosphorylation PhosphoSitePlus
Y4864 Phosphorylation PhosphoSitePlus   UniProt 18318008
S4867 Phosphorylation PhosphoSitePlus   UniProt 18318008
Site PTM Type PTM Enzyme Score Source PMID
Y1965 Phosphorylation HPRD 19664994
S2843 Phosphorylation Q13555 (CAMK2G) , Q13976 (PRKG1) , P17612 (PRKACA) HPRD 8380342, 14532276
T3079 Phosphorylation HPRD 17322306
Site PTM Type PTM Enzyme Score Source PMID
Y1965 Phosphorylation HPRD 19664994
T3079 Phosphorylation HPRD 17322306


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S421 N421 Biomuta DOID:363 / uterine cancer [ icgc ]
S587 F587 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
S781 R781 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C810 S810 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C2326 G2326 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2459 F2459 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2459 C2459 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2594 L2594 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T2596 N2596 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S2843 L2843 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2868 F2868 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K2953 T2953 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S3027 I3027 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S3027 R3027 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S3032 Y3032 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y3131 C3131 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y3131 N3131 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T3177 A3177 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T4823 M4823 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ]
T4826 I4826 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S4867 N4867 Biomuta DOID:4159 / skin cancer [ cosmic ]