Protein Information

Cytoscape View


UniProt AC / UniProt ID P21802 / FGFR2_HUMAN
Protein Name Fibroblast growth factor receptor 2 precursor
Gene Name Name: FGFR2
Synonyms:BEK,KGFR,KSAM;
Organism Homo sapiens (Human)

PRO ID PR:P21802
DAG View
PRO Name fibroblast growth factor receptor 2 (human)
Definition A fibroblast growth factor receptor 2 that is encoded in the genome of human.
Short Label hFGFR2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P21802 (FGFR2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
T40 O-Glycosylation GlyGen 30459171
N83 N-Glycosylation GlyGen 30237853
S347 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
T442 Phosphorylation PhosphoSitePlus
T448 Phosphorylation PhosphoSitePlus
T449 Phosphorylation PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus
S453 Phosphorylation PhosphoSitePlus
T454 Phosphorylation PhosphoSitePlus
T457 Phosphorylation PhosphoSitePlus
Y466 Phosphorylation P21802 (FGFR2) neXtProt   PhosphoSitePlus   UniProt 19410646, 19060208
S533 Phosphorylation PhosphoSitePlus
K539 Acetylation PhosphoSitePlus
Y586 Phosphorylation P21802 (FGFR2) neXtProt   PhosphoSitePlus   UniProt 17803937, 19410646, 19060208
S587 Phosphorylation PhosphoSitePlus
Y588 Phosphorylation P21802 (FGFR2) neXtProt   PhosphoSitePlus   UniProt 19410646, 19060208
Y608 Phosphorylation PhosphoSitePlus
Y616 Phosphorylation PhosphoSitePlus
Y656 Phosphorylation P21802 (FGFR2) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 17803937, 19410646, 32409632, ...19060208
Y657 Phosphorylation P21802 (FGFR2) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 17803937, 19410646, 32409632, ...19060208
Y733 Phosphorylation PhosphoSitePlus
K751 Ubiquitination PhosphoSitePlus
Y769 Phosphorylation P21802 (FGFR2) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 15629145, 19410646, 19060208
S780 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 24275569, 31146385
S782 Phosphorylation Q02156 (PRKCE) neXtProt   PhosphoSitePlus   Signor 23564461
S788 Phosphorylation PhosphoSitePlus
S789 Phosphorylation PhosphoSitePlus
S791 Phosphorylation PhosphoSitePlus
S792 Phosphorylation PhosphoSitePlus
Y805 Phosphorylation PhosphoSitePlus
Y812 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y769 Phosphorylation HPRD 9266968
Y779 Phosphorylation HPRD 9266968
Y783 Phosphorylation HPRD 9266968
Y812 Phosphorylation HPRD 9266968
Site PTM Type PTM Enzyme Score Source PMID
S430 Phosphorylation PhosphoSitePlus
Y655 Phosphorylation PhosphoSitePlus
Y656 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y770 Phosphorylation HPRD 9266968
Y780 Phosphorylation HPRD 9266968
Y784 Phosphorylation HPRD 9266968
Y813 Phosphorylation HPRD 9266968


P21802 (FGFR2) as PTM Enzyme



Substrate Site Score Source PMID
P21802 (FGFR2) Y466 neXtProt   UniProt 19410646, 19060208
P21802 (FGFR2) Y586 neXtProt   UniProt 17803937, 19410646, 19060208
P21802 (FGFR2) Y588 neXtProt   UniProt 19410646, 19060208
P21802 (FGFR2) Y656 neXtProt   UniProt 17803937, 19410646, 19060208
P21802 (FGFR2) Y657 neXtProt   UniProt 17803937, 19410646, 19060208
P21802 (FGFR2) Y769 neXtProt   PhosphoSitePlus   UniProt 15629145, 19410646, 19060208
P35222 (CTNNB1) Y142 PhosphoSitePlus 22558232
P60484 (PTEN) Y240 PhosphoSitePlus   Signor 22891331
P62993 (GRB2) Y209 neXtProt 22726438


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047413 (hFGFR2/SigPep-/PhosTyr+) p PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T40 N40 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
N83 D83 Biomuta DOID:363 / uterine cancer [ tcga ]
S437 F437 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S440 F440 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T448 K448 Biomuta DOID:3571 / liver cancer [ icgc ]
T449 A449 Biomuta DOID:1909 / melanoma [ cosmic ]
T454 M454 Biomuta DOID:363 / uterine cancer [ tcga ]
S533 P533 Biomuta DOID:1909 / melanoma [ cosmic ]
S587 C587 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
Y657 * Biomuta DOID:3571 / liver cancer [ icgc ]
Y769 * Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:10534 / stomach cancer [ cosmic, icgc ]
Y779 C779 Biomuta DOID:363 / uterine cancer [ tcga ]
S780 L780 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S791 T791 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
S792 L792 Biomuta DOID:4362 / cervical cancer [ tcga ]
S792 * Biomuta DOID:1324 / lung cancer [ tcga ]