iPTMnet Report P21731 TBXA2R

Protein Information

Cytoscape View

UniProt AC / UniProt ID	P21731 / TA2R_HUMAN
Protein Name	Thromboxane A2 receptor
Gene Name	Name: TBXA2R
Organism	Homo sapiens (Human)

PRO ID	PR:P21731 DAG View
PRO Name	thromboxane A2 receptor (human)
Definition	A thromboxane A2 receptor that is encoded in the genome of human.
Short Label	hTBXA2R
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P21731 (TBXA2R) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	N4	N-Glycosylation		score2	GlyGen	9587408
	N16	N-Glycosylation		score3	GlyGen	9587408, 9694965
	S118	Phosphorylation		score1	PhosphoSitePlus
	S128	Phosphorylation		score1	PhosphoSitePlus
	S145	Phosphorylation		score1	PhosphoSitePlus
	S324	Phosphorylation	P17252 (PRKCA)	score2	PhosphoSitePlus	12370102
	S329	Phosphorylation	P17612 (PRKACA) , P17252 (PRKCA)	score4	PhosphoSitePlus UniProt	12370102, 20068231, 10827090
	S331	Phosphorylation	P17612 (PRKACA) , P17252 (PRKCA)	score4	PhosphoSitePlus Signor	12147288, 12370102
	T337	Phosphorylation	P17252 (PRKCA)	score2	PhosphoSitePlus	15100160

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S145	Phosphorylation		score1	PhosphoSitePlus
	S239	Phosphorylation	P35626 (GRK3) , P25098 (GRK2)	score2	PhosphoSitePlus	16956790
	S330	Phosphorylation	P17612 (PRKACA) , Q13976 (PRKG1)	score3	PhosphoSitePlus	12147288, 14530262
	T332	Phosphorylation	Q13976 (PRKG1) , P17612 (PRKACA)	score2	PhosphoSitePlus	14530262
	S357	Phosphorylation	P35626 (GRK3) , P25098 (GRK2)	score2	PhosphoSitePlus	16956790
	T399	Phosphorylation	P17252 (PRKCA)	score2	PhosphoSitePlus	15100160

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S329	Phosphorylation		score0	HPRD	19651622, 18578522, 20068231
	S331	Phosphorylation		score0	HPRD	19651622, 18578522

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
T337	M337	Biomuta		DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]