iPTMnet Report for P21580 (TNFAIP3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P21580 / TNAP3_HUMAN
Protein Name Tumor necrosis factor alpha-induced protein 3
Gene Name Name: TNFAIP3
Synonyms:OTUD7C;
Organism Homo sapiens (Human)

PRO ID PR:P21580
DAG View
PRO Name tumor necrosis factor alpha-induced protein 3 (human)
Definition A tumor necrosis factor alpha-induced protein 3 that is encoded in the genome of human.
Short Label hTNFAIP3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P21580 (TNFAIP3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
K66 Ubiquitination PhosphoSitePlus
K81 Acetylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
T118 Phosphorylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus
T129 Phosphorylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
T179 Phosphorylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
Y306 Phosphorylation HPRD   PhosphoSitePlus 19413330
T321 Phosphorylation HPRD   PhosphoSitePlus 19413330
T322 Phosphorylation HPRD   PhosphoSitePlus 19413330
K337 Ubiquitination PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus   RLIMS-P 33154446, 33549127
S423 Phosphorylation PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
T454 Phosphorylation PhosphoSitePlus
S459 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S466 Phosphorylation PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
S568 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S573 Phosphorylation HPRD   PhosphoSitePlus 20068231
S575 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 20068231, 17081983, 24275569
S578 Phosphorylation HPRD   PhosphoSitePlus 20068231
C590 Methylation IEDB 31844290
S592 Phosphorylation PhosphoSitePlus
T597 O-Glycosylation GlyGen 29351928
T597 Phosphorylation PhosphoSitePlus
K609 Ubiquitination PhosphoSitePlus
Y614 Phosphorylation PhosphoSitePlus
T617 Phosphorylation PhosphoSitePlus
K621 Ubiquitination PhosphoSitePlus
T625 Phosphorylation PhosphoSitePlus
Y631 Phosphorylation PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
S645 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 19415658, 20068231, ...17081983
T647 Phosphorylation PhosphoSitePlus
S649 Phosphorylation HPRD   PhosphoSitePlus 17081983
C657 Methylation IEDB 31844290
Y673 Phosphorylation PhosphoSitePlus
K676 Ubiquitination PhosphoSitePlus
S699 Phosphorylation PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
K722 Ubiquitination PhosphoSitePlus
S729 Phosphorylation PhosphoSitePlus
Y778 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K81 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K81 N81 Biomuta DOID:1612 / breast cancer [ cosmic ]
K82 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T118 I118 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T129 M129 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K131 R131 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K131 Q131 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K131 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y306 S306 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K337 T337 Biomuta DOID:1612 / breast cancer [ cosmic ]
K354 N354 Biomuta DOID:363 / uterine cancer [ cosmic ]
S376 F376 Biomuta DOID:4159 / skin cancer [ cosmic ]
S459 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S459 L459 Biomuta [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S459 W459 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S480 N480 Biomuta DOID:1612 / breast cancer [ cosmic ]
S573 N573 Biomuta DOID:1612 / breast cancer [ cosmic ]
S578 C578 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
Y614 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y614 C614 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y614 S614 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K643 N643 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T647 P647 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T647 I647 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K676 Q676 Biomuta DOID:263 / kidney cancer [ cosmic ]
S729 N729 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
Y778 C778 Biomuta DOID:1324 / lung cancer [ cosmic ]