iPTMnet Report for P21579 (SYT1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P21579 / SYT1_HUMAN
Protein Name Synaptotagmin-1
Gene Name Name: SYT1
Synonyms:SVP65,SYT;
Organism Homo sapiens (Human)

PRO ID PR:P21579
DAG View
PRO Name synaptotagmin-1 (human)
Definition A synaptotagmin-1 that is encoded in the genome of human.
Short Label hSYT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P21579 (SYT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S24 Phosphorylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
T126 Phosphorylation PhosphoSitePlus
T129 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18510355, 21406692
K134 Ubiquitination PhosphoSitePlus
Y181 Phosphorylation PhosphoSitePlus
T202 Phosphorylation HPRD   PhosphoSitePlus 19664994
T212 Phosphorylation HPRD   PhosphoSitePlus 19664994
Y217 Phosphorylation PhosphoSitePlus
Y230 Phosphorylation PhosphoSitePlus
K237 Acetylation PhosphoSitePlus
K302 Acetylation PhosphoSitePlus
Y312 Phosphorylation PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K120 N120 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K134 T134 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y181 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y230 C230 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K333 N333 Biomuta DOID:9256 / colorectal cancer [ cosmic ]