iPTMnet Report for P21453 (S1PR1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P21453 / S1PR1_HUMAN
Protein Name Sphingosine 1-phosphate receptor 1
Gene Name Name: S1PR1
Synonyms:CHEDG1,EDG1;
Organism Homo sapiens (Human)

PRO ID PR:P21453
DAG View
PRO Name sphingosine 1-phosphate receptor 1 (human)
Definition A sphingosine 1-phosphate receptor 1 that is encoded in the genome of human.
Short Label hS1PR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P21453 (S1PR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T4 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S5 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
N30 N-Glycosylation GlyGen   UniProt 15750791, 22344443, 24190977
S129 Phosphorylation PhosphoSitePlus
Y143 Phosphorylation PhosphoSitePlus   RLIMS-P 25588843
T236 Phosphorylation P31749 (AKT1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 11583630
K330 Acetylation PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S5 R5 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y143 H143 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S351 R351 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S355 L355 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S359 C359 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S359 F359 Biomuta DOID:4159 / skin cancer [ cosmic ]