Protein Information

Cytoscape View


UniProt AC / UniProt ID P21399 / ACOC_HUMAN
Protein Name Cytoplasmic aconitate hydratase
Gene Name Name: ACO1
Synonyms:IREB1;
Organism Homo sapiens (Human)

PRO ID PR:P21399
DAG View
PRO Name cytoplasmic aconitate hydratase (human)
Definition A cytoplasmic aconitate hydratase that is encoded in the genome of human.
Short Label hACO1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P21399 (ACO1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K26 Ubiquitination PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
S138 Phosphorylation P17252 (PRKCA) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 28768766, 16424901, 8262977, ...8024572
K141 Ubiquitination PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
Y184 Phosphorylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
T258 Phosphorylation PhosphoSitePlus
T318 Phosphorylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
Y336 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
Y466 Phosphorylation HPRD   PhosphoSitePlus 20068231
S533 Phosphorylation PhosphoSitePlus
K572 Ubiquitination PhosphoSitePlus
K580 Ubiquitination PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
K610 Ubiquitination PhosphoSitePlus
K615 Ubiquitination PhosphoSitePlus
S622 Phosphorylation PhosphoSitePlus
T628 Phosphorylation PhosphoSitePlus   UniProt 24275569
K632 Ubiquitination PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
K639 Ubiquitination PhosphoSitePlus
K644 Ubiquitination PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus
R699 Methylation PhosphoSitePlus
S711 Phosphorylation P17252 (PRKCA) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 15263083, 8262977, 15636585
R713 Methylation PhosphoSitePlus
R721 Methylation PhosphoSitePlus
R728 Methylation PhosphoSitePlus
K736 Ubiquitination PhosphoSitePlus
K772 Ubiquitination PhosphoSitePlus
K785 Ubiquitination PhosphoSitePlus
S799 Phosphorylation PhosphoSitePlus
Y800 Phosphorylation PhosphoSitePlus
S806 Phosphorylation PhosphoSitePlus
K844 Ubiquitination PhosphoSitePlus
K852 Ubiquitination PhosphoSitePlus
K857 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K105 E105 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
K141 N141 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T318 M318 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K335 T335 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S383 P383 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S383 A383 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
K387 R387 Biomuta DOID:1115 / sarcoma [ tcga ]
S533 Y533 Biomuta DOID:3953 / adrenal gland cancer [ tcga ]
K580 R580 Biomuta DOID:3571 / liver cancer [ tcga ]
R699 K699 Biomuta DOID:1324 / lung cancer [ tcga ]
R713 L713 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R721 W721 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R728 C728 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]