iPTMnet Report for P21359 (NF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P21359 / NF1_HUMAN
Protein Name Neurofibromin
Gene Name Name: NF1
Organism Homo sapiens (Human)

PRO ID PR:P21359
DAG View
PRO Name neurofibromin (human)
Definition A neurofibromin that is encoded in the genome of human.
Short Label hNF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P21359 (NF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
K24 Ubiquitination PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
C118 Methylation IEDB 31844290
K261 Ubiquitination PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
C324 Methylation IEDB 31844290
K362 Ubiquitination PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
T467 Phosphorylation PhosphoSitePlus
K469 Methylation PhosphoSitePlus
K471 Methylation PhosphoSitePlus
K476 Methylation PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
K478 Ubiquitination PhosphoSitePlus
Y491 Phosphorylation PhosphoSitePlus
K505 Ubiquitination PhosphoSitePlus
C582 Methylation IEDB 31844290
S657 Phosphorylation PhosphoSitePlus
S674 Phosphorylation PhosphoSitePlus
T676 Phosphorylation PhosphoSitePlus
K783 Ubiquitination PhosphoSitePlus
K796 Ubiquitination PhosphoSitePlus
K798 Ubiquitination PhosphoSitePlus
S807 Phosphorylation PhosphoSitePlus
K810 Ubiquitination PhosphoSitePlus
T811 O-Glycosylation GlyGen 31492838
T862 Phosphorylation PhosphoSitePlus
Y863 Phosphorylation PhosphoSitePlus
S864 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 18669648, ...19690332, 20068231
K874 Ubiquitination PhosphoSitePlus
S876 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S879 Phosphorylation PhosphoSitePlus
S882 Phosphorylation PhosphoSitePlus
S883 Phosphorylation PhosphoSitePlus
T915 Phosphorylation PhosphoSitePlus
S926 Phosphorylation PhosphoSitePlus
Y930 Phosphorylation PhosphoSitePlus
K1036 Ubiquitination PhosphoSitePlus
C1063 Methylation IEDB 31844290
R1204 Methylation PhosphoSitePlus
K1283 Acetylation PhosphoSitePlus
T1456 Phosphorylation PhosphoSitePlus
K1517 Ubiquitination PhosphoSitePlus
Y1521 Phosphorylation PhosphoSitePlus
S1567 Phosphorylation PhosphoSitePlus
K1581 Acetylation PhosphoSitePlus
K1701 Ubiquitination PhosphoSitePlus
K1745 Ubiquitination PhosphoSitePlus
T1751 Phosphorylation PhosphoSitePlus
C1882 Methylation IEDB 31844290
K2049 Ubiquitination PhosphoSitePlus
S2188 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16565220
Y2192 Phosphorylation PhosphoSitePlus
T2444 Phosphorylation PhosphoSitePlus
S2446 Phosphorylation PhosphoSitePlus
S2451 Phosphorylation PhosphoSitePlus
S2460 Phosphorylation PhosphoSitePlus
Y2476 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K2489 Methylation PhosphoSitePlus
K2489 Ubiquitination PhosphoSitePlus
T2491 Phosphorylation PhosphoSitePlus
S2495 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2496 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2500 Phosphorylation PhosphoSitePlus
Y2503 Phosphorylation PhosphoSitePlus
T2507 Phosphorylation PhosphoSitePlus
Y2508 Phosphorylation PhosphoSitePlus
T2514 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2515 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 15302935, ...18669648, 19690332
K2520 Methylation PhosphoSitePlus
S2521 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S2523 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S2543 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...24275569
S2561 Phosphorylation PhosphoSitePlus
T2564 Phosphorylation PhosphoSitePlus
T2565 Phosphorylation PhosphoSitePlus   UniProt 23186163
T2575 Phosphorylation PhosphoSitePlus
Y2577 Phosphorylation PhosphoSitePlus
T2581 Phosphorylation PhosphoSitePlus
S2587 Phosphorylation PhosphoSitePlus
K2595 Ubiquitination PhosphoSitePlus
S2597 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2599 Phosphorylation PhosphoSitePlus
S2802 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2810 Phosphorylation PhosphoSitePlus
S2817 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231, 24275569
S2819 Phosphorylation PhosphoSitePlus
S2829 Phosphorylation phospho.ELM   PhosphoSitePlus 16083285
S2834 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S56 Phosphorylation HPRD 20068231
T59 Phosphorylation HPRD 20068231
T60 Phosphorylation HPRD 20068231
S864 Phosphorylation HPRD 19413330, 18669648, 19664994, ...20068231
T1456 Phosphorylation HPRD 18452278
S2188 Phosphorylation HPRD 18691976, 18669648, 19691289
Y2476 Phosphorylation HPRD 18083107
S2495 Phosphorylation HPRD 18669648
S2496 Phosphorylation HPRD 18691976, 18669648
T2507 Phosphorylation HPRD 18767875
Y2508 Phosphorylation HPRD 18767875
T2510 Phosphorylation HPRD 18767875
T2514 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S2515 Phosphorylation HPRD 17322306, 18669648, 20058876, ...20068231, 18452278
S2521 Phosphorylation HPRD 18669648
S2523 Phosphorylation HPRD 19413330, 18669648
S2543 Phosphorylation HPRD 19651622, 18691976, 18578522, ...18669648
Y2577 Phosphorylation HPRD 17389395
S2597 Phosphorylation HPRD 18691976
S2802 Phosphorylation HPRD 20068231
S2817 Phosphorylation HPRD 19651622, 20068231
S2819 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S56 Phosphorylation HPRD 20068231
T59 Phosphorylation HPRD 20068231
T60 Phosphorylation HPRD 20068231
S864 Phosphorylation HPRD 19413330, 15302935, 18669648, ...19664994, 20068231
T1435 Phosphorylation HPRD 18452278
S2167 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18669648, 19691289, ...16565220
Y2455 Phosphorylation HPRD 18083107
S2474 Phosphorylation HPRD 18669648
S2475 Phosphorylation HPRD 18691976, 18669648
T2486 Phosphorylation HPRD 18767875
Y2487 Phosphorylation HPRD 18767875
T2489 Phosphorylation HPRD 18767875
T2493 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S2494 Phosphorylation HPRD 15302935, 18669648, 20058876, ...20068231, 18452278
S2500 Phosphorylation HPRD 18669648
S2502 Phosphorylation HPRD 19413330, 18669648
S2522 Phosphorylation HPRD 19651622, 18691976, 18578522, ...18669648
T2544 Phosphorylation PhosphoSitePlus
T2554 Phosphorylation PhosphoSitePlus
Y2556 Phosphorylation HPRD 17389395
S2576 Phosphorylation HPRD   PhosphoSitePlus 18691976
S2578 Phosphorylation PhosphoSitePlus
S2580 Phosphorylation PhosphoSitePlus
S2781 Phosphorylation HPRD 20068231
S2796 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
S2798 Phosphorylation HPRD 20068231
S2808 Phosphorylation P17252 (PRKCA) HPRD   PhosphoSitePlus 26490262, 16083285
S2813 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S593 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048585 (hNF1/InitMet-/UbiqLys+) ub PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q7Z699 (SPRED1) S105 P21359 (NF1) inhibited_association eFIP 32697994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K40 R40 Biomuta DOID:1612 / breast cancer [ cosmic ]
T59 P59 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
C118 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K297 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K297 T297 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C324 R324 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
C324 S324 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K449 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T467 I467 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:3953 / adrenal gland cancer [ cosmic ]
K469 Q469 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K478 T478 Biomuta [ cosmic ]
Y491 C491 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
Y491 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K505 E505 Biomuta DOID:3571 / liver cancer [ cosmic ]
K796 N796 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K798 Q798 Biomuta DOID:3571 / liver cancer [ cosmic ]
K810 R810 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K810 * Biomuta [ cosmic ]
T862 S862 Biomuta DOID:4159 / skin cancer [ cosmic ]
T862 I862 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y863 * Biomuta DOID:1319 / brain cancer [ cosmic ]
K1036 * Biomuta DOID:1612 / breast cancer [ cosmic ]
C1063 * Biomuta [ cosmic ]
R1204 W1204 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:2394 / ovarian cancer [ cosmic ]
K1517 E1517 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y1521 C1521 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1567 A1567 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1567 * Biomuta [ cosmic ] DOID:4362 / cervical cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K1581 Q1581 Biomuta DOID:1319 / brain cancer [ icgc ]
K1581 * Biomuta [ cosmic ]
K1701 R1701 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K1701 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C1882 F1882 Biomuta DOID:1324 / lung cancer [ cosmic ]
C1882 Y1882 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S2167 F2167 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S2188 F2188 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ tcga ]
Y2192 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
Y2455 F2455 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2460 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S2474 F2474 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2475 F2475 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y2476 F2476 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T2486 I2486 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y2487 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
T2493 I2493 Biomuta DOID:1319 / brain cancer [ cosmic ]
S2495 F2495 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2496 F2496 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2500 P2500 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S2502 N2502 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
Y2503 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y2503 C2503 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T2507 I2507 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y2508 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
T2514 I2514 Biomuta DOID:1319 / brain cancer [ cosmic ]
S2523 N2523 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S2561 * Biomuta [ cosmic ]
S2561 L2561 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S2576 L2576 Biomuta [ cosmic ]
S2576 * Biomuta [ cosmic ]
S2578 F2578 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2580 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K2595 E2595 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K2595 * Biomuta DOID:1319 / brain cancer [ cosmic ]
S2597 L2597 Biomuta [ cosmic ]
S2597 * Biomuta [ cosmic ]
S2599 F2599 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2781 F2781 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2796 F2796 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S2802 F2802 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2810 G2810 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2817 F2817 Biomuta DOID:1612 / breast cancer [ cosmic ]