iPTMnet Report for P21333 (FLNA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P21333 / FLNA_HUMAN
Protein Name Filamin-A
Gene Name Name: FLNA
Synonyms:FLN,FLN1;
Organism Homo sapiens (Human)

PRO ID PR:P21333
DAG View
PRO Name filamin-A (human)
Definition A filamin-A that is encoded in the genome of human.
Short Label hFLNA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P21333 (FLNA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 25944712
S2 Phosphorylation PhosphoSitePlus
S3 Phosphorylation PhosphoSitePlus
S4 Phosphorylation PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus
R7 Methylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus   UniProt 21406692
T23 Phosphorylation PhosphoSitePlus
T31 Phosphorylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
K42 Acetylation PhosphoSitePlus
K42 Methylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus   UniProt 24052262
K43 Ubiquitination PhosphoSitePlus   UniProt 24052262
T48 Phosphorylation PhosphoSitePlus
T50 Phosphorylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
T69 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K92 Acetylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
K135 Ubiquitination UniProt 24052262
K169 Acetylation PhosphoSitePlus
T186 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
Y287 Phosphorylation PhosphoSitePlus
K299 Acetylation PhosphoSitePlus
K299 Sumoylation PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
Y319 Phosphorylation PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
Y373 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K376 Acetylation PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
S382 Phosphorylation PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
T385 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
Y403 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
C444 S-Nitrosylation dbSNO 20140087
S468 Phosphorylation PhosphoSitePlus
Y470 Phosphorylation PhosphoSitePlus
T471 Phosphorylation PhosphoSitePlus
C478 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
S481 Phosphorylation PhosphoSitePlus
C483 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
R488 Methylation PhosphoSitePlus
T500 Phosphorylation PhosphoSitePlus
K504 Acetylation PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
Y506 Phosphorylation PhosphoSitePlus
T507 Phosphorylation PhosphoSitePlus
K508 Acetylation PhosphoSitePlus   UniProt 19608861
K508 Ubiquitination PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
T518 Phosphorylation PhosphoSitePlus
Y538 Phosphorylation PhosphoSitePlus
K578 Acetylation PhosphoSitePlus
K578 Ubiquitination PhosphoSitePlus
R580 Methylation PhosphoSitePlus
C623 S-Nitrosylation dbSNO 26338901
K626 Acetylation PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
C631 S-Nitrosylation dbSNO 26338901
Y643 Phosphorylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus
S657 Phosphorylation PhosphoSitePlus
R674 Methylation PhosphoSitePlus
K684 Ubiquitination PhosphoSitePlus
T685 Phosphorylation PhosphoSitePlus
K691 Methylation PhosphoSitePlus
K691 Ubiquitination PhosphoSitePlus
K700 Acetylation PhosphoSitePlus   UniProt 19608861
K700 Ubiquitination PhosphoSitePlus
K704 Ubiquitination PhosphoSitePlus
C717 S-Nitrosylation dbSNO 25040305, 2212679, 22126794, ...19366988, 18335467
T730 Phosphorylation PhosphoSitePlus
Y731 Phosphorylation PhosphoSitePlus
S732 Phosphorylation PhosphoSitePlus
C733 S-Nitrosylation dbSNO 2212679, 22126794
S734 Phosphorylation PhosphoSitePlus
Y735 Phosphorylation PhosphoSitePlus
S748 Phosphorylation PhosphoSitePlus
S753 Phosphorylation PhosphoSitePlus
S757 Phosphorylation PhosphoSitePlus
S767 Phosphorylation PhosphoSitePlus
K771 Acetylation PhosphoSitePlus
K771 Ubiquitination PhosphoSitePlus
K773 Ubiquitination PhosphoSitePlus
Y775 Phosphorylation PhosphoSitePlus
K781 Acetylation PhosphoSitePlus   UniProt 19608861
K781 Ubiquitination PhosphoSitePlus
T782 Phosphorylation PhosphoSitePlus
T790 Phosphorylation PhosphoSitePlus
Y791 Phosphorylation PhosphoSitePlus
T793 Phosphorylation PhosphoSitePlus
C810 S-Nitrosylation dbSNO 20140087
K837 Acetylation PhosphoSitePlus   UniProt 19608861
K837 Ubiquitination PhosphoSitePlus
T859 Phosphorylation PhosphoSitePlus
S860 Phosphorylation PhosphoSitePlus
K865 Acetylation PhosphoSitePlus
K865 Ubiquitination PhosphoSitePlus
S869 Phosphorylation PhosphoSitePlus
K874 Acetylation PhosphoSitePlus
K876 Ubiquitination PhosphoSitePlus
S883 Phosphorylation PhosphoSitePlus
K891 Acetylation PhosphoSitePlus
K891 Ubiquitination PhosphoSitePlus
K906 Acetylation PhosphoSitePlus
K906 Ubiquitination PhosphoSitePlus
S912 Phosphorylation PhosphoSitePlus
T915 Phosphorylation PhosphoSitePlus
K916 Ubiquitination PhosphoSitePlus
Y933 Phosphorylation PhosphoSitePlus
T950 Phosphorylation PhosphoSitePlus
K958 Ubiquitination PhosphoSitePlus
S959 Phosphorylation PhosphoSitePlus
S962 Phosphorylation PhosphoSitePlus
S966 Phosphorylation PhosphoSitePlus
S968 Phosphorylation PhosphoSitePlus
S972 O-Glycosylation GlyGen 23301498, 16408927, 30444036, ...18369606, 35138101, 34019948, 30397120, 34725712, 26853435, 33214551, 35254053, 35132862, 35083852, 35008409, 33465208, 28510447, 32119511, 29351928, 34229054
S972 Phosphorylation PhosphoSitePlus
K973 Acetylation PhosphoSitePlus
K973 Ubiquitination PhosphoSitePlus
K975 Ubiquitination PhosphoSitePlus
S977 Phosphorylation PhosphoSitePlus
K982 Ubiquitination PhosphoSitePlus
K987 Acetylation PhosphoSitePlus
K987 Ubiquitination PhosphoSitePlus
K994 Acetylation PhosphoSitePlus
K1003 Ubiquitination PhosphoSitePlus
K1007 Ubiquitination PhosphoSitePlus
C1018 Methylation IEDB 31844290
C1018 S-Nitrosylation dbSNO 26338901
K1019 Acetylation PhosphoSitePlus
K1019 Ubiquitination PhosphoSitePlus
S1029 Phosphorylation PhosphoSitePlus
Y1047 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
S1055 O-Glycosylation GlyGen 23301498, 16408927, 30444036, ...18369606, 35138101, 34019948, 30397120, 34725712, 26853435, 33214551, 35254053, 35132862, 35083852, 35008409, 33465208, 28510447, 32119511, 29351928, 34229054
S1055 Phosphorylation PhosphoSitePlus   UniProt 24275569
K1071 Acetylation PhosphoSitePlus
K1071 Ubiquitination PhosphoSitePlus
S1081 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...18669648, 24275569, 20068231
S1084 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 18088087, 16964243, ...18220336, 25445790, 15302935, 18669648, 23186163, 19690332, 20068231, 17924679
R1087 Methylation PhosphoSitePlus
T1089 Phosphorylation PhosphoSitePlus   UniProt 17081983
C1157 S-Nitrosylation dbSNO 26338901
S1161 Phosphorylation PhosphoSitePlus
K1162 Acetylation PhosphoSitePlus
K1162 Ubiquitination PhosphoSitePlus
K1164 Ubiquitination PhosphoSitePlus
C1165 Methylation IEDB 31844290
K1246 Ubiquitination PhosphoSitePlus
T1255 Phosphorylation PhosphoSitePlus
C1260 S-Nitrosylation dbSNO 25040305, 20140087
Y1261 Phosphorylation PhosphoSitePlus
S1279 Phosphorylation PhosphoSitePlus
T1286 Phosphorylation PhosphoSitePlus
T1288 Phosphorylation PhosphoSitePlus
K1294 Ubiquitination PhosphoSitePlus
S1301 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1305 Phosphorylation PhosphoSitePlus
T1307 Phosphorylation PhosphoSitePlus
Y1308 Phosphorylation PhosphoSitePlus
R1312 Methylation PhosphoSitePlus
T1334 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1338 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1343 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1367 O-Glycosylation GlyGen 23301498, 16408927, 30444036, ...18369606, 35138101, 34019948, 30397120, 34725712, 26853435, 33214551, 35254053, 35132862, 35083852, 35008409, 33465208, 28510447, 32119511, 29351928, 34229054
S1367 Phosphorylation PhosphoSitePlus
K1372 Ubiquitination PhosphoSitePlus
K1375 Acetylation PhosphoSitePlus
T1377 Phosphorylation PhosphoSitePlus
T1385 Phosphorylation PhosphoSitePlus
S1396 Phosphorylation PhosphoSitePlus
K1399 Ubiquitination PhosphoSitePlus
S1436 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus   RLIMS-P 17408621
T1446 Phosphorylation PhosphoSitePlus
S1449 Phosphorylation PhosphoSitePlus
K1452 Ubiquitination PhosphoSitePlus
C1453 S-Nitrosylation dbSNO 2212679, 22126794
S1454 Phosphorylation PhosphoSitePlus
S1459 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 18088087, 16964243, ...25445790, 15302935, 19367720, 18669648, 20179208, 24275569, 23186163, 20068231, 17081983
S1470 Phosphorylation PhosphoSitePlus
T1475 Phosphorylation PhosphoSitePlus
S1476 O-Glycosylation GlyGen 23301498, 16408927, 30444036, ...18369606, 35138101, 34019948, 30397120, 34725712, 26853435, 33214551, 35254053, 35132862, 35083852, 35008409, 33465208, 28510447, 32119511, 29351928, 34229054
S1476 Phosphorylation PhosphoSitePlus
K1477 Ubiquitination PhosphoSitePlus
K1486 Ubiquitination PhosphoSitePlus
K1491 Ubiquitination PhosphoSitePlus
T1506 Phosphorylation PhosphoSitePlus
Y1511 Phosphorylation PhosphoSitePlus
S1514 Phosphorylation PhosphoSitePlus
S1520 Phosphorylation PhosphoSitePlus
S1522 Phosphorylation PhosphoSitePlus
Y1525 Phosphorylation PhosphoSitePlus
S1533 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 25445790, 18669648, ...17408621, 20068231
K1538 Acetylation PhosphoSitePlus
K1538 Ubiquitination PhosphoSitePlus
K1547 Ubiquitination PhosphoSitePlus
S1551 Phosphorylation PhosphoSitePlus
T1557 O-Glycosylation GlyGen 23301498, 16408927, 30444036, ...18369606, 35138101, 34019948, 30397120, 34725712, 26853435, 33214551, 35254053, 35132862, 35083852, 35008409, 33465208, 28510447, 32119511, 29351928, 34229054
T1557 Phosphorylation PhosphoSitePlus
T1558 O-Glycosylation GlyGen 23301498, 16408927, 30444036, ...18369606, 35138101, 34019948, 30397120, 34725712, 26853435, 33214551, 35254053, 35132862, 35083852, 35008409, 33465208, 28510447, 32119511, 29351928, 34229054
S1563 Phosphorylation PhosphoSitePlus
T1585 Phosphorylation PhosphoSitePlus
K1590 Ubiquitination PhosphoSitePlus
T1594 Phosphorylation PhosphoSitePlus
T1603 Phosphorylation PhosphoSitePlus
Y1604 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T1605 Phosphorylation PhosphoSitePlus
T1617 Phosphorylation PhosphoSitePlus
K1621 Ubiquitination PhosphoSitePlus
Y1622 Phosphorylation PhosphoSitePlus
S1630 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 17408621, 18669648, 23186163
Y1632 Phosphorylation PhosphoSitePlus
T1639 Phosphorylation PhosphoSitePlus
Y1720 Phosphorylation PhosphoSitePlus
C1723 Methylation IEDB 31844290
S1734 Phosphorylation PhosphoSitePlus   UniProt 20068231, 24275569
T1739 Phosphorylation PhosphoSitePlus
Y1761 Phosphorylation PhosphoSitePlus
T1762 Phosphorylation PhosphoSitePlus
Y1763 Phosphorylation PhosphoSitePlus
K1801 Ubiquitination PhosphoSitePlus
K1814 Ubiquitination PhosphoSitePlus
K1824 Acetylation PhosphoSitePlus
K1824 Ubiquitination PhosphoSitePlus
S1835 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1854 Phosphorylation PhosphoSitePlus
Y1862 Phosphorylation PhosphoSitePlus
C1865 Methylation IEDB 31844290
Y1871 Phosphorylation PhosphoSitePlus
S1899 Phosphorylation PhosphoSitePlus
S1906 Phosphorylation PhosphoSitePlus
C1912 S-Nitrosylation dbSNO 26338901
C1920 S-Nitrosylation dbSNO 26338901
Y1932 Phosphorylation PhosphoSitePlus
K1937 Ubiquitination PhosphoSitePlus
Y1938 Phosphorylation PhosphoSitePlus
S1946 Phosphorylation PhosphoSitePlus
S1961 Phosphorylation PhosphoSitePlus
K1964 Ubiquitination PhosphoSitePlus
S1967 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1976 Phosphorylation PhosphoSitePlus
S1981 Phosphorylation PhosphoSitePlus
T1984 Phosphorylation PhosphoSitePlus
S1991 Phosphorylation PhosphoSitePlus
K2000 Acetylation PhosphoSitePlus
K2000 Ubiquitination PhosphoSitePlus
S2010 Phosphorylation PhosphoSitePlus
K2024 Ubiquitination PhosphoSitePlus
S2033 Phosphorylation PhosphoSitePlus
S2053 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T2062 Phosphorylation PhosphoSitePlus
S2088 Phosphorylation PhosphoSitePlus
S2128 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S2131 Phosphorylation PhosphoSitePlus
K2133 Ubiquitination PhosphoSitePlus
T2135 Phosphorylation PhosphoSitePlus
K2141 Ubiquitination PhosphoSitePlus
S2143 Phosphorylation PhosphoSitePlus
T2145 Phosphorylation PhosphoSitePlus
S2152 Phosphorylation P31749 (AKT1) , Q15418 (RPS6KA1) , P17612 (PRKACA) , Q13153 (PAK1) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15024089, 26134617, 30568657, ...25068602, 31632499, 21406692, 23186163, 23340249, 12198493, 24275569, 25944616, 18088087, 20006946, 21807941, 21507248, 27059097, 34150753, 17081983, 25666618, 29284605, 18669648, 20179208, 33134326, 26460884, 27909248, 20068231, 15228085
S2158 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 23186163, 24275569
C2160 Methylation IEDB 31844290
S2163 Phosphorylation PhosphoSitePlus   UniProt 24275569
S2180 Phosphorylation PhosphoSitePlus
S2182 Phosphorylation PhosphoSitePlus
K2184 Ubiquitination PhosphoSitePlus
Y2198 Phosphorylation PhosphoSitePlus
C2199 S-Nitrosylation dbSNO 25040305, 2212679, 22126794, ...26338901
T2209 Phosphorylation PhosphoSitePlus
S2213 Phosphorylation PhosphoSitePlus
K2217 Methylation PhosphoSitePlus
K2217 Ubiquitination PhosphoSitePlus
S2224 Phosphorylation PhosphoSitePlus
T2229 Phosphorylation PhosphoSitePlus
K2240 Ubiquitination PhosphoSitePlus
R2242 Methylation PhosphoSitePlus
S2260 Phosphorylation PhosphoSitePlus
S2284 Phosphorylation PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
K2289 Ubiquitination PhosphoSitePlus
S2292 Phosphorylation Q13153 (PAK1) PhosphoSitePlus 12198493
C2293 S-Nitrosylation dbSNO 26338901
Y2305 Phosphorylation PhosphoSitePlus
S2308 Phosphorylation PhosphoSitePlus
S2319 Phosphorylation PhosphoSitePlus
S2327 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
T2336 Phosphorylation PhosphoSitePlus   UniProt 25666618, 23186163, 20068231
S2338 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2339 Phosphorylation PhosphoSitePlus
S2343 Phosphorylation PhosphoSitePlus
S2352 Phosphorylation PhosphoSitePlus
S2356 Phosphorylation PhosphoSitePlus
K2361 Ubiquitination PhosphoSitePlus
K2367 Ubiquitination PhosphoSitePlus
S2370 Phosphorylation Q13153 (PAK1) PhosphoSitePlus 12198493
S2372 Phosphorylation PhosphoSitePlus
Y2379 Phosphorylation PhosphoSitePlus
T2381 Phosphorylation PhosphoSitePlus
K2387 Acetylation PhosphoSitePlus
K2387 Ubiquitination PhosphoSitePlus
Y2388 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
Y2400 Phosphorylation PhosphoSitePlus
S2414 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
K2417 Acetylation PhosphoSitePlus
K2417 Ubiquitination PhosphoSitePlus
K2473 Ubiquitination PhosphoSitePlus
C2476 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
C2479 Methylation IEDB 31844290
C2479 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
Y2483 Phosphorylation PhosphoSitePlus
T2486 Phosphorylation PhosphoSitePlus
T2488 Phosphorylation PhosphoSitePlus
S2494 Phosphorylation PhosphoSitePlus
Y2505 Phosphorylation PhosphoSitePlus
S2510 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K2513 Ubiquitination PhosphoSitePlus
S2523 Phosphorylation Q9UQM7 (CAMK2A) phospho.ELM   PhosphoSitePlus 11290523
S2526 Phosphorylation PhosphoSitePlus
S2537 Phosphorylation PhosphoSitePlus
K2540 Ubiquitination PhosphoSitePlus
T2542 Phosphorylation PhosphoSitePlus
C2543 S-Nitrosylation dbSNO 25040305, 2212679, 22126794, ...26338901, 20140087
K2563 Ubiquitination PhosphoSitePlus
K2569 Acetylation PhosphoSitePlus
K2569 Ubiquitination PhosphoSitePlus
Y2571 Phosphorylation PhosphoSitePlus
K2575 Ubiquitination PhosphoSitePlus
S2576 Phosphorylation PhosphoSitePlus
S2577 Phosphorylation PhosphoSitePlus
C2582 S-Nitrosylation dbSNO 26338901
K2584 Ubiquitination PhosphoSitePlus
T2599 Phosphorylation PhosphoSitePlus
C2601 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
K2607 Acetylation PhosphoSitePlus   UniProt 19608861
Y2614 Phosphorylation PhosphoSitePlus
S2615 Phosphorylation PhosphoSitePlus
S2617 O-Glycosylation GlyGen 23301498, 16408927, 30444036, ...18369606, 35138101, 34019948, 30397120, 34725712, 26853435, 33214551, 35254053, 35132862, 35083852, 35008409, 33465208, 28510447, 32119511, 29351928, 34229054
S2617 Phosphorylation PhosphoSitePlus
K2621 Acetylation PhosphoSitePlus   UniProt 19608861
K2623 Acetylation PhosphoSitePlus
K2623 Ubiquitination PhosphoSitePlus
Y2626 Phosphorylation PhosphoSitePlus
T2627 Phosphorylation PhosphoSitePlus
K2631 Ubiquitination PhosphoSitePlus
S2640 Phosphorylation PhosphoSitePlus
Y2642 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231
S3 Phosphorylation HPRD 20068231
S4 Phosphorylation HPRD 20068231
S6 Phosphorylation HPRD 20068231
S11 Phosphorylation HPRD 20068231
T23 Phosphorylation HPRD 20068231
T31 Phosphorylation HPRD 20068231
Y373 Phosphorylation HPRD 18083107
S564 Phosphorylation HPRD 20068231
S757 Phosphorylation HPRD 20068231
S966 Phosphorylation HPRD 19664995
Y1047 Phosphorylation HPRD 15592455
S1081 Phosphorylation HPRD 18691976, 17081983, 18767875, ...19664995, 19651622, 18669648, 20068231
S1084 Phosphorylation HPRD 19413330, 18691976, 18491316, ...18088087, 18212344, 16964243, 18767875, 19664994, 19007248, 18452278, 17322306, 18669648, 19664995, 19651622, 19415658, 20068231, 17924679
T1089 Phosphorylation HPRD 17081983
T1288 Phosphorylation HPRD 20068231
T1334 Phosphorylation HPRD 18669648, 20068231
S1338 Phosphorylation HPRD 18669648, 18452278
S1343 Phosphorylation HPRD 18669648
S1436 Phosphorylation HPRD 17408621
S1459 Phosphorylation HPRD 18691976, 18491316, 18088087, ...16964243, 18767875, 19664994, 19664995, 19651622, 17322306, 18669648, 20058876, 20166139, 19415658, 20068231, 18212344
Y1525 Phosphorylation HPRD 17081983
S1533 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
Y1604 Phosphorylation HPRD 18083107
S1630 Phosphorylation HPRD 18669648, 19664994, 19664995, ...20068231
S1726 Phosphorylation HPRD 20068231
S1938 Phosphorylation HPRD 20068231
S2024 Phosphorylation HPRD 17081983, 20068231
S2025 Phosphorylation HPRD 17081983
S2045 Phosphorylation HPRD 18669648, 20068231
S2120 Phosphorylation HPRD 19651622, 18669648, 20068231
S2123 Phosphorylation HPRD 20068231
S2144 Phosphorylation HPRD 18578522, 18088087, 18767875, ...20058876, 19664995, 18452278, 19651622, 18669648, 15225631, 20166139, 20068231
S2150 Phosphorylation HPRD 20166139, 18088087, 17081983, ...20068231
S2155 Phosphorylation HPRD 19651622, 17081983, 20068231
S2162 Phosphorylation HPRD 20068231
S2276 Phosphorylation HPRD 17081983, 20068231
S2319 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 19664995
S2321 Phosphorylation HPRD 19651622, 17081983, 20068231
T2328 Phosphorylation HPRD 20166139, 20068231
S2330 Phosphorylation HPRD 20068231
S2335 Phosphorylation HPRD 20068231
Y2380 Phosphorylation HPRD 18083107
S2406 Phosphorylation HPRD 18669648, 20068231
T2478 Phosphorylation HPRD 20068231
Y2479 Phosphorylation HPRD 20068231
S2502 Phosphorylation HPRD 18669648, 20068231
S2515 Phosphorylation Q13555 (CAMK2G) HPRD 11290523


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047426 (hFLNA/InitMet-/Phos:1) pS2152 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P21333 (FLNA) S2152 P20701 (ITGAL) increased_association eFIP 30568657


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 F4 Biomuta DOID:4159 / skin cancer [ cosmic ]
R7 G7 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
R7 P7 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K33 M33 Biomuta DOID:4159 / skin cancer [ cosmic ]
T69 M69 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S72 R72 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K169 T169 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y319 C319 Biomuta DOID:363 / uterine cancer [ cosmic ]
T333 A333 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K376 M376 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T385 A385 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y470 C470 Biomuta DOID:1319 / brain cancer [ cosmic ]
K508 N508 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T518 N518 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S564 C564 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:1324 / lung cancer [ cosmic ]
R580 W580 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K626 R626 Biomuta DOID:363 / uterine cancer [ icgc ]
R674 M674 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C717 S717 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
C717 Y717 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y731 H731 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S753 G753 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S753 R753 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S757 N757 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
K771 N771 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T793 I793 Biomuta DOID:4159 / skin cancer [ cosmic ]
K837 R837 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T859 N859 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S860 N860 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S912 L912 Biomuta DOID:1612 / breast cancer [ cosmic ]
T915 A915 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y933 H933 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T950 P950 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S959 R959 Biomuta DOID:1324 / lung cancer [ cosmic ]
K975 N975 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:5041 / esophageal cancer [ cosmic, cosmic ] DOID:1324 / lung cancer [ cosmic ]
K1003 T1003 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1029 N1029 Biomuta DOID:3571 / liver cancer [ cosmic ]
R1087 H1087 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
R1087 L1087 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R1087 C1087 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
C1157 R1157 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y1261 H1261 Biomuta DOID:363 / uterine cancer [ icgc ]
K1294 N1294 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1301 L1301 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T1377 I1377 Biomuta DOID:1319 / brain cancer [ icgc ]
T1385 K1385 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K1399 R1399 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1459 N1459 Biomuta DOID:363 / uterine cancer [ icgc ]
S1459 R1459 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y1511 F1511 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1514 G1514 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T1594 K1594 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T1603 M1603 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
Y1604 F1604 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1854 R1854 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1862 C1862 Biomuta DOID:4362 / cervical cancer [ cosmic ]
Y1862 * Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:3571 / liver cancer [ cosmic ]
Y1871 C1871 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1899 F1899 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C1912 F1912 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1932 S1932 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y1938 H1938 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1938 C1938 Biomuta DOID:363 / uterine cancer [ icgc ]
S1961 P1961 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1961 F1961 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T1984 M1984 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2010 L2010 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2123 Y2123 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S2123 F2123 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2131 F2131 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2131 Y2131 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S2144 L2144 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S2152 L2152 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S2155 I2155 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2163 I2163 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2182 L2182 Biomuta DOID:4159 / skin cancer [ cosmic ]
K2184 R2184 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C2199 Y2199 Biomuta DOID:363 / uterine cancer [ icgc ]
R2242 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K2289 N2289 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S2352 Y2352 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S2370 N2370 Biomuta [ cosmic ]
S2372 L2372 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K2473 Q2473 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y2483 C2483 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2515 T2515 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
S2523 T2523 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S2526 I2526 Biomuta DOID:1319 / brain cancer [ icgc ]
S2537 F2537 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C2543 F2543 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T2599 N2599 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S2617 P2617 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K2621 R2621 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K2621 N2621 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K2623 N2623 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]