Protein Information

Cytoscape View

UniProt AC / UniProt ID P21281 / VATB2_HUMAN
Protein Name V-type proton ATPase subunit B, brain isoform
Gene Name Name: ATP6V1B2
Organism Homo sapiens (Human)

PRO ID PR:P21281
DAG View
PRO Name V-type proton ATPase subunit B, brain isoform (human)
Definition A V-type proton ATPase subunit B, brain isoform that is encoded in the genome of human.
Short Label hATP6V1B2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P21281 (ATP6V1B2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
R4 Methylation PhosphoSitePlus
R7 Methylation PhosphoSitePlus
Y39 Phosphorylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
R44 Methylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
T49 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
R67 Methylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
K108 Acetylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
C112 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
S124 Phosphorylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
S182 Phosphorylation HPRD   PhosphoSitePlus 18452278
R185 Methylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
Y328 Phosphorylation PhosphoSitePlus
Y389 Phosphorylation HPRD 20068231
S397 Phosphorylation HPRD   PhosphoSitePlus 20068231
S399 Phosphorylation HPRD   PhosphoSitePlus 20068231
K403 Ubiquitination PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
R460 Methylation PhosphoSitePlus
R506 Methylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R7 L7 Biomuta DOID:3571 / liver cancer [ icgc ]
R7 Q7 Biomuta DOID:3963 / thyroid carcinoma [ icgc ]
S41 C41 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
R44 C44 Biomuta DOID:11934 / head and neck cancer [ tcga ]
R44 G44 Biomuta DOID:1612 / breast cancer [ cosmic ]
K108 N108 Biomuta DOID:363 / uterine cancer [ tcga ]
S182 I182 Biomuta DOID:363 / uterine cancer [ tcga ]
K188 T188 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
Y222 C222 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc ]
S397 P397 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K457 T457 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]