iPTMnet Report for P21127 (CDK11B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P21127 / CD11B_HUMAN
Protein Name Cyclin-dependent kinase 11B
Gene Name Name: CDK11B
Synonyms:CDC2L1,CDK11,PITSLREA,PK58;
Organism Homo sapiens (Human)

PRO ID PR:P21127
DAG View
PRO Name cyclin-dependent kinase 11B (human)
Definition A cyclin-dependent kinase 11B that is encoded in the genome of human.
Short Label hCDK11B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P21127 (CDK11B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K11 Sumoylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
K20 Sumoylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
K29 Sumoylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
T61 Phosphorylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
Y67 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
K101 Acetylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
S115 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15883043
K120 Acetylation PhosphoSitePlus
K135 Acetylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
K225 Acetylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
S234 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K266 Sumoylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
S283 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983, 18220336, 15302935, ...18669648, 16964243
S285 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S358 Phosphorylation PhosphoSitePlus
S381 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S384 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T395 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T402 Phosphorylation PhosphoSitePlus
Y406 Phosphorylation PhosphoSitePlus
S410 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S414 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K419 Sumoylation PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
T448 Phosphorylation PhosphoSitePlus
Y449 Phosphorylation PhosphoSitePlus
Y453 Phosphorylation PhosphoSitePlus
K456 Acetylation PhosphoSitePlus
K458 Acetylation PhosphoSitePlus
K459 Acetylation PhosphoSitePlus
K459 Sumoylation PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
K467 Acetylation PhosphoSitePlus
K467 Sumoylation PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
S482 Phosphorylation UniProt 16327805
T488 Phosphorylation UniProt 16327805
K491 Sumoylation PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
K564 Sumoylation PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
Y587 Phosphorylation PhosphoSitePlus
S589 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 15302935, 33936100, 27920218, ...18669648, 19690332
Y594 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T595 Phosphorylation P50613 (CDK7) phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 23186163, 16964243, ...18220336, 15302935, 16327805, 18669648, 19690332, 20068231, 17081983
T600 Phosphorylation PhosphoSitePlus
K641 Sumoylation PhosphoSitePlus
K641 Ubiquitination PhosphoSitePlus
K649 Sumoylation PhosphoSitePlus
K649 Ubiquitination PhosphoSitePlus
K652 Sumoylation PhosphoSitePlus
K652 Ubiquitination PhosphoSitePlus
K660 Ubiquitination PhosphoSitePlus
K672 Ubiquitination PhosphoSitePlus
K673 Sumoylation PhosphoSitePlus
K673 Ubiquitination PhosphoSitePlus
T675 Phosphorylation PhosphoSitePlus
S713 Phosphorylation PhosphoSitePlus
K719 Sumoylation PhosphoSitePlus
K719 Ubiquitination PhosphoSitePlus
T726 Phosphorylation Q9UQ88 (CDK11A) PhosphoSitePlus   Signor 21078675
K741 Sumoylation PhosphoSitePlus
K741 Ubiquitination PhosphoSitePlus
T751 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983, 18220336
S752 Phosphorylation O96017 (CHEK2) phospho.ELM   PhosphoSitePlus 23178491, 17081983, 18220336
Y762 Phosphorylation PhosphoSitePlus
S763 Phosphorylation PhosphoSitePlus
T773 Phosphorylation PhosphoSitePlus
T778 Phosphorylation PhosphoSitePlus
S785 Phosphorylation PhosphoSitePlus
S792 Phosphorylation PhosphoSitePlus
K794 Methylation PhosphoSitePlus
K794 Sumoylation PhosphoSitePlus
K794 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S17 Phosphorylation HPRD 19007248, 20068231
S47 Phosphorylation HPRD 19664994, 20068231, 18452278
S53 Phosphorylation HPRD 17322306, 16964243, 20230923, ...20058876, 19664994, 18452278, 19651622, 19415658, 20068231
S55 Phosphorylation HPRD 18452278, 20230923
T165 Phosphorylation HPRD 18452278
T172 Phosphorylation HPRD 18452278
S180 Phosphorylation HPRD 18452278
S184 Phosphorylation HPRD 18452278
Y283 Phosphorylation HPRD 20068231
S295 Phosphorylation HPRD 20068231
Y357 Phosphorylation HPRD 18452278
S359 Phosphorylation HPRD 20068231, 18452278
T365 Phosphorylation HPRD 19413330, 17322306, 16964243, ...18767875, 18452278, 19651622, 20068231
T521 Phosphorylation HPRD 19651622, 20068231
S522 Phosphorylation HPRD 19651622, 20068231
S533 Phosphorylation HPRD 20166139
Site PTM Type PTM Enzyme Score Source PMID
T370 Phosphorylation Q9UQ88-10 (CDK11A) PhosphoSitePlus 21078675
Site PTM Type PTM Enzyme Score Source PMID
K253 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation HPRD 19664994, 20068231, 18452278
S14 Phosphorylation HPRD 17322306, 16964243, 20230923, ...20058876, 19664994, 18452278, 19651622, 19415658, 20068231
S16 Phosphorylation HPRD 18452278, 20230923
T126 Phosphorylation HPRD 18452278
T133 Phosphorylation HPRD 18452278
S141 Phosphorylation HPRD 18452278
S145 Phosphorylation HPRD 18452278
Y244 Phosphorylation HPRD 20068231
S256 Phosphorylation HPRD 20068231
Y318 Phosphorylation HPRD 18452278
S320 Phosphorylation HPRD 20068231, 18452278
T326 Phosphorylation HPRD 19413330, 17322306, 16964243, ...18767875, 18452278, 19651622, 20068231
T482 Phosphorylation HPRD 19651622, 20068231
S483 Phosphorylation HPRD 19651622, 20068231
S494 Phosphorylation HPRD 20166139
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
K219 Sumoylation PhosphoSitePlus


P21127 (CDK11B) as PTM Enzyme



Substrate Site Score Source PMID
O00303 (EIF3F) S46 PhosphoSitePlus   Signor 12446680
O00303 (EIF3F) T119 Signor 19245811