iPTMnet Report for P20963 (CD247)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P20963 / CD3Z_HUMAN
Protein Name T-cell surface glycoprotein CD3 zeta chain precursor
Gene Name Name: CD247
Synonyms:CD3Z,T3Z,TCRZ;
Organism Homo sapiens (Human)

PRO ID PR:P20963
DAG View
PRO Name T-cell surface glycoprotein CD3 (human)
Definition A T-cell surface glycoprotein CD3 that is encoded in the genome of human.
Short Label hCD247
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P20963 (CD247) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S58 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15144186
Y64 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455, 19690332, 15144186, ...16094384
Y72 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   UniProt 24502978, 15659558, 7528772, ...16094384, 15832366, 15144186, 8901551, 8648092, 9185620, 15592455, 10704231, 19690332
Y83 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   UniProt 15659558, 7528772, 16094384, ...15832366, 8901551, 8648092, 9185620, 15592455, 12522270, 10704231
K88 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
Y111 Phosphorylation P06241 (FYN) IntAct   phospho.ELM   PhosphoSitePlus   UniProt 8901551, 15659558, 7528772, ...16094384, 15144186, 18083107, 10752619, 15592455, 12522270, 8578591, 19690332
K116 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
Y123 Phosphorylation P06241 (FYN) IntAct   phospho.ELM   PhosphoSitePlus   UniProt 10752619, 15659558, 7528772, ...16094384, 12522270, 8578591, 19690332
S124 Phosphorylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
Y142 Phosphorylation P06239 (LCK) IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 24502978, 15659558, 7528772, ...16094384, 15144186, 7509083, 8901551, 15592455, 19690332, 32757378, 12522270, 7544002, 20541955
S146 Phosphorylation PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
T149 Phosphorylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
T152 Phosphorylation PhosphoSitePlus
Y153 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15659558, 19690332, 16094384
Site PTM Type PTM Enzyme Score Source PMID
S58 Phosphorylation HPRD 15144186
Y64 Phosphorylation HPRD 15144186
Y72 Phosphorylation HPRD 15144186
Y83 Phosphorylation HPRD 12522270, 9677202
Y111 Phosphorylation HPRD 12522270, 9677202, 15144186
Y123 Phosphorylation HPRD 12522270, 9677202
Y142 Phosphorylation HPRD 12522270, 9677202, 15144186
Y153 Phosphorylation HPRD 15659558
Site PTM Type PTM Enzyme Score Source PMID
S58 Phosphorylation HPRD 15144186
Y64 Phosphorylation HPRD 15144186
Y72 Phosphorylation HPRD 15144186
Y83 Phosphorylation HPRD 12522270, 9677202
K99 Ubiquitination PhosphoSitePlus
Y110 Phosphorylation HPRD   PhosphoSitePlus 12522270, 9677202, 15144186
Y122 Phosphorylation HPRD 12522270, 9677202
Y141 Phosphorylation HPRD 12522270, 9677202, 15144186
Y152 Phosphorylation HPRD 15659558


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K88 N88 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S146 G146 Biomuta DOID:1319 / brain cancer [ cosmic ]