iPTMnet Report for P20839 (IMPDH1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P20839 / IMDH1_HUMAN
Protein Name Inosine-5'-monophosphate dehydrogenase 1
Gene Name Name: IMPDH1
Synonyms:IMPD1;
Organism Homo sapiens (Human)

PRO ID PR:P20839
DAG View
PRO Name inosine-5'-monophosphate dehydrogenase 1 (human)
Definition An inosine-5'-monophosphate dehydrogenase 1 that is encoded in the genome of human.
Short Label hIMPDH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P20839 (IMPDH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K109 Ubiquitination PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus   UniProt 23186163
K169 Ubiquitination PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
R203 Methylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
R231 Methylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
K242 Acetylation PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
T252 Phosphorylation PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
T306 Phosphorylation PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
R322 Methylation PhosphoSitePlus
Y400 Phosphorylation PhosphoSitePlus
K410 Ubiquitination PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
Y430 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
K436 Acetylation PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
K450 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T194 Phosphorylation HPRD 20068231
S201 Phosphorylation HPRD 20068231
T208 Phosphorylation HPRD 20068231
T229 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T6 Phosphorylation PhosphoSitePlus
Y36 Phosphorylation PhosphoSitePlus
Y45 Phosphorylation PhosphoSitePlus
T60 Phosphorylation HPRD   PhosphoSitePlus 18491316
S63 Phosphorylation HPRD   PhosphoSitePlus 18491316
S66 Phosphorylation HPRD   PhosphoSitePlus 18491316
S85 Phosphorylation PhosphoSitePlus
T230 Phosphorylation HPRD 20068231
S237 Phosphorylation HPRD 20068231
T244 Phosphorylation HPRD 20068231
T265 Phosphorylation HPRD 20068231
K327 Acetylation PhosphoSitePlus
Y485 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T6 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
T108 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S63 P63 Biomuta DOID:4159 / skin cancer [ cosmic ]
T229 A229 Biomuta DOID:1319 / brain cancer [ icgc ]
T229 M229 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T265 M265 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T265 A265 Biomuta DOID:1319 / brain cancer [ icgc ]