Protein Information

Cytoscape View


UniProt AC / UniProt ID P20810 / ICAL_HUMAN
Protein Name Calpastatin
Gene Name Name: CAST
Organism Homo sapiens (Human)

PRO ID PR:P20810
DAG View
PRO Name calpastatin (human)
Definition A calpastatin that is encoded in the genome of human.
Short Label hCAST
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P20810 (CAST) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T4 Phosphorylation PhosphoSitePlus
K32 Sumoylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
K43 Acetylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus   RLIMS-P 27626661
K51 Methylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
K56 Methylation PhosphoSitePlus
K58 Methylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
K123 Acetylation PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
T135 Phosphorylation PhosphoSitePlus
S142 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K146 Ubiquitination PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
T189 Phosphorylation PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
T200 Phosphorylation phospho.ELM 1995645
K204 Acetylation PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
Y205 Phosphorylation phospho.ELM 1995645
K212 Ubiquitination PhosphoSitePlus
S222 Phosphorylation phospho.ELM 18669648
S223 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S237 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T240 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S243 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935
T245 Phosphorylation PhosphoSitePlus
K249 Acetylation PhosphoSitePlus
K261 Methylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
T267 Phosphorylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
T300 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
K313 Acetylation PhosphoSitePlus
C328 S-Nitrosylation dbSNO 26338901
Y339 Phosphorylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
S364 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S366 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S373 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S379 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
C381 S-Nitrosylation dbSNO 26338901
T389 Phosphorylation PhosphoSitePlus
S404 O-Glycosylation GlyGen 23301498, 16408927, 28657654, ...31637018
C408 S-Nitrosylation dbSNO 26338901, 22178444, 20140087
T410 Phosphorylation phospho.ELM 18669648
S411 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
C413 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
S414 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K443 Acetylation PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
Y481 Phosphorylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
K500 Acetylation PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
S516 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S526 Phosphorylation PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus   UniProt 24275569
K529 Acetylation PhosphoSitePlus
K534 Ubiquitination PhosphoSitePlus
T546 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus
T560 Phosphorylation PhosphoSitePlus
S561 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S563 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K573 Acetylation PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
S577 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
K606 Acetylation PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
T613 Phosphorylation PhosphoSitePlus
Y618 Phosphorylation PhosphoSitePlus
K629 Acetylation PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
K636 Ubiquitination PhosphoSitePlus
S655 Phosphorylation PhosphoSitePlus
S660 Phosphorylation PhosphoSitePlus
C661 S-Nitrosylation dbSNO 20140087, 22178444
T664 Phosphorylation PhosphoSitePlus
S668 Phosphorylation PhosphoSitePlus
T671 Phosphorylation PhosphoSitePlus
K678 Ubiquitination PhosphoSitePlus
K684 Acetylation PhosphoSitePlus
K687 Acetylation PhosphoSitePlus
K691 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S71 Phosphorylation HPRD 20068231
S108 Phosphorylation HPRD 20068231
S113 Phosphorylation HPRD 20068231
S133 Phosphorylation HPRD 19651622, 20068231
S142 Phosphorylation HPRD 17287340, 20068231
S183 Phosphorylation HPRD 18452278
S187 Phosphorylation HPRD 18452278
S188 Phosphorylation HPRD 18452278
T189 Phosphorylation HPRD 18452278
Y190 Phosphorylation HPRD 18452278
S222 Phosphorylation HPRD 18669648, 20068231
S237 Phosphorylation HPRD 18669648
T240 Phosphorylation HPRD 18669648
S243 Phosphorylation HPRD 19413330, 18491316, 19664994, ...18452278, 18669648, 19415658, 20068231
T245 Phosphorylation HPRD 19415658
S364 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S366 Phosphorylation HPRD 18669648, 18452278, 17081983, ...18707149
S373 Phosphorylation HPRD 18669648
S379 Phosphorylation HPRD 18669648
T410 Phosphorylation HPRD 18669648
S411 Phosphorylation HPRD 18669648
S414 Phosphorylation HPRD 20068231
S516 Phosphorylation HPRD 18669648, 20068231
S526 Phosphorylation HPRD 20068231
S561 Phosphorylation HPRD 18669648
S563 Phosphorylation HPRD 18669648, 18452278
S575 Phosphorylation HPRD 19651622, 20068231, 18452278
S577 Phosphorylation HPRD 20166139, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231
S11 Phosphorylation HPRD 19651622, 20068231
S34 Phosphorylation HPRD 19651622, 20068231
S36 Phosphorylation HPRD 19651622
S51 Phosphorylation HPRD 20068231
S132 Phosphorylation HPRD 20068231
S169 Phosphorylation HPRD 20068231
S174 Phosphorylation HPRD 20068231
S194 Phosphorylation HPRD 19651622, 20068231
S203 Phosphorylation HPRD 17287340, 20068231
S244 Phosphorylation HPRD 18452278
S248 Phosphorylation HPRD 18452278
S249 Phosphorylation HPRD 18452278
T250 Phosphorylation HPRD 18452278
Y251 Phosphorylation HPRD 18452278
S283 Phosphorylation HPRD 18669648, 20068231
S298 Phosphorylation HPRD 18669648
T301 Phosphorylation HPRD 18669648
S304 Phosphorylation HPRD 19413330, 18491316, 19664994, ...18452278, 18669648, 19415658, 20068231
T306 Phosphorylation HPRD 19415658
S425 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S427 Phosphorylation HPRD 18669648, 18452278, 17081983, ...18707149
S434 Phosphorylation HPRD 18669648
S440 Phosphorylation HPRD 18669648
T471 Phosphorylation HPRD 18669648
S472 Phosphorylation HPRD 18669648
S475 Phosphorylation HPRD 20068231
S577 Phosphorylation HPRD 18669648, 20068231
S587 Phosphorylation HPRD 20068231
S622 Phosphorylation HPRD 18669648
S624 Phosphorylation HPRD 18669648, 18452278
S636 Phosphorylation HPRD 19651622, 20068231, 18452278
S638 Phosphorylation HPRD 20166139, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S230 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S30 Phosphorylation HPRD 20068231
S67 Phosphorylation HPRD 20068231
S72 Phosphorylation HPRD 20068231
S92 Phosphorylation HPRD 19651622, 20068231
S101 Phosphorylation HPRD 17287340, 20068231
S142 Phosphorylation HPRD 18452278
S146 Phosphorylation HPRD 18452278
S147 Phosphorylation HPRD 18452278
T148 Phosphorylation HPRD 18452278
Y149 Phosphorylation HPRD 18452278
S181 Phosphorylation HPRD 18669648, 20068231
S196 Phosphorylation HPRD 18669648
T199 Phosphorylation HPRD 18669648
S202 Phosphorylation HPRD 19413330, 18491316, 19664994, ...18452278, 18669648, 19415658, 20068231
T204 Phosphorylation HPRD 19415658
S323 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S325 Phosphorylation HPRD 18669648, 18452278, 17081983, ...18707149
S332 Phosphorylation HPRD 18669648
S338 Phosphorylation HPRD 18669648
T369 Phosphorylation HPRD 18669648
S370 Phosphorylation HPRD 18669648
S373 Phosphorylation HPRD 20068231
S475 Phosphorylation HPRD 18669648, 20068231
S485 Phosphorylation HPRD 20068231
S520 Phosphorylation HPRD 18669648
S522 Phosphorylation HPRD 18669648, 18452278
S534 Phosphorylation HPRD 19651622, 20068231, 18452278
S536 Phosphorylation HPRD 20166139, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
K48 Methylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
T60 Phosphorylation PhosphoSitePlus
Y61 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
K80 Methylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
T87 Phosphorylation PhosphoSitePlus
T89 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD   PhosphoSitePlus 20068231
S11 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
S32 Phosphorylation PhosphoSitePlus
S34 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
S36 Phosphorylation HPRD 19651622
K48 Ubiquitination PhosphoSitePlus
S51 Phosphorylation HPRD   PhosphoSitePlus 20068231
S54 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
K80 Methylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
S154 Phosphorylation HPRD 20068231
S191 Phosphorylation HPRD 20068231
S196 Phosphorylation HPRD 20068231
S216 Phosphorylation HPRD 19651622, 20068231
S225 Phosphorylation HPRD 17287340, 20068231
S266 Phosphorylation HPRD 18452278
S270 Phosphorylation HPRD 18452278
S271 Phosphorylation HPRD 18452278
T272 Phosphorylation HPRD 18452278
Y273 Phosphorylation HPRD 18452278
T283 Phosphorylation HPRD 1995645
Y288 Phosphorylation HPRD 1995645
S305 Phosphorylation HPRD 18669648, 20068231
S320 Phosphorylation HPRD 18669648
T323 Phosphorylation HPRD 18669648
S326 Phosphorylation HPRD 19413330, 18491316, 19664994, ...15302935, 18452278, 18669648, 19415658, 20068231
T328 Phosphorylation HPRD 19415658
S447 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S449 Phosphorylation HPRD 18669648, 18452278, 17081983, ...18707149
S456 Phosphorylation HPRD 18669648
S462 Phosphorylation HPRD 18669648
T493 Phosphorylation HPRD 18669648
S494 Phosphorylation HPRD 18669648
S497 Phosphorylation HPRD 20068231
S599 Phosphorylation HPRD 18669648, 20068231
S609 Phosphorylation HPRD 20068231
S644 Phosphorylation HPRD 18669648
S646 Phosphorylation HPRD 18669648, 18452278
S658 Phosphorylation HPRD 19651622, 20068231, 18452278
S660 Phosphorylation HPRD 20166139, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231
S11 Phosphorylation HPRD 19651622, 20068231
S34 Phosphorylation HPRD 19651622, 20068231
S36 Phosphorylation HPRD 19651622
S51 Phosphorylation HPRD 20068231
S135 Phosphorylation HPRD 20068231
S172 Phosphorylation HPRD 20068231
S177 Phosphorylation HPRD 20068231
S197 Phosphorylation HPRD 19651622, 20068231
S206 Phosphorylation HPRD 17287340, 20068231
S247 Phosphorylation HPRD 18452278
S251 Phosphorylation HPRD 18452278
S252 Phosphorylation HPRD 18452278
T253 Phosphorylation HPRD 18452278
Y254 Phosphorylation HPRD 18452278
S286 Phosphorylation HPRD 18669648, 20068231
S301 Phosphorylation HPRD 18669648
T304 Phosphorylation HPRD 18669648
S307 Phosphorylation HPRD 19413330, 18491316, 19664994, ...18452278, 18669648, 19415658, 20068231
T309 Phosphorylation HPRD 19415658
S428 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S430 Phosphorylation HPRD 18669648, 18452278, 17081983, ...18707149
S437 Phosphorylation HPRD 18669648
S443 Phosphorylation HPRD 18669648
T474 Phosphorylation HPRD 18669648
S475 Phosphorylation HPRD 18669648
S478 Phosphorylation HPRD 20068231
S580 Phosphorylation HPRD 18669648, 20068231
S590 Phosphorylation HPRD 20068231
S625 Phosphorylation HPRD 18669648
S627 Phosphorylation HPRD 18669648, 18452278
S639 Phosphorylation HPRD 19651622, 20068231, 18452278
S641 Phosphorylation HPRD 20166139, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S49 Phosphorylation HPRD 20068231
S86 Phosphorylation HPRD 20068231
S91 Phosphorylation HPRD 20068231
S111 Phosphorylation HPRD 19651622, 20068231
S120 Phosphorylation HPRD 17287340, 20068231
S161 Phosphorylation HPRD 18452278
S165 Phosphorylation HPRD 18452278
S166 Phosphorylation HPRD 18452278
T167 Phosphorylation HPRD 18452278
Y168 Phosphorylation HPRD 18452278
T178 Phosphorylation HPRD 1995645
S200 Phosphorylation HPRD 18669648, 20068231
S215 Phosphorylation HPRD 18669648
T218 Phosphorylation HPRD 18669648
S221 Phosphorylation HPRD 19413330, 18491316, 19664994, ...15302935, 18452278, 18669648, 19415658, 20068231
T223 Phosphorylation HPRD 19415658
S342 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S344 Phosphorylation HPRD 18669648, 18452278, 17081983, ...18707149
S351 Phosphorylation HPRD 18669648
S357 Phosphorylation HPRD 18669648
T388 Phosphorylation HPRD 18669648
S389 Phosphorylation HPRD 18669648
S392 Phosphorylation HPRD 20068231
S494 Phosphorylation HPRD 18669648, 20068231
S504 Phosphorylation HPRD 20068231
S539 Phosphorylation HPRD 18669648
S541 Phosphorylation HPRD 18669648, 18452278
S553 Phosphorylation HPRD 19651622, 20068231, 18452278
S555 Phosphorylation HPRD 20166139, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231
S11 Phosphorylation HPRD 19651622, 20068231
S34 Phosphorylation HPRD 19651622, 20068231
S36 Phosphorylation HPRD 19651622
S51 Phosphorylation HPRD 20068231
S113 Phosphorylation HPRD 20068231
S150 Phosphorylation HPRD 20068231
S155 Phosphorylation HPRD 20068231
S175 Phosphorylation HPRD 19651622, 20068231
S184 Phosphorylation HPRD 17287340, 20068231
S225 Phosphorylation HPRD 18452278
S229 Phosphorylation HPRD 18452278
S230 Phosphorylation HPRD 18452278
T231 Phosphorylation HPRD 18452278
Y232 Phosphorylation HPRD 18452278
S264 Phosphorylation HPRD 18669648, 20068231
S279 Phosphorylation HPRD 18669648
T282 Phosphorylation HPRD 18669648
S285 Phosphorylation HPRD 19413330, 18491316, 19664994, ...18452278, 18669648, 19415658, 20068231
T287 Phosphorylation HPRD 19415658
S406 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S408 Phosphorylation HPRD 18669648, 18452278, 17081983, ...18707149
S415 Phosphorylation HPRD 18669648
S421 Phosphorylation HPRD 18669648
T452 Phosphorylation HPRD 18669648
S453 Phosphorylation HPRD 18669648
S456 Phosphorylation HPRD 20068231
S558 Phosphorylation HPRD 18669648, 20068231
S568 Phosphorylation HPRD 20068231
S603 Phosphorylation HPRD 18669648
S605 Phosphorylation HPRD 18669648, 18452278
S617 Phosphorylation HPRD 19651622, 20068231, 18452278
S619 Phosphorylation HPRD 20166139, 18669648, 20068231