iPTMnet Report for P20807 (CAPN3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P20807 / CAN3_HUMAN
Protein Name Calpain-3
Gene Name Name: CAPN3
Synonyms:CANP3,CANPL3,NCL1;
Organism Homo sapiens (Human)

PRO ID PR:P20807
DAG View
PRO Name calpain-3 (human)
Definition A calpain-3 that is encoded in the genome of human.
Short Label hCAPN3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P20807 (CAPN3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
S202 O-Glycosylation GlyGen 29351928
S279 Phosphorylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus
T599 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
S629 Phosphorylation PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus
S699 Phosphorylation PhosphoSitePlus
S709 Phosphorylation PhosphoSitePlus
K729 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T417 Phosphorylation HPRD 20068231
S423 Phosphorylation HPRD 20068231
S432 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T369 Phosphorylation HPRD 20068231
S375 Phosphorylation HPRD 20068231
S384 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T417 Phosphorylation HPRD 20068231
S423 Phosphorylation HPRD 20068231
S432 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S8 Y8 Biomuta DOID:1319 / brain cancer [ icgc ]
S279 F279 Biomuta DOID:4159 / skin cancer [ cosmic ]
T369 M369 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, cosmic, icgc ]
T417 M417 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T599 N599 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]
S699 I699 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]